NBME CBSE 2025 TEST. ACTUAL EXAM
QUESTIONS AND ANSWERS. LATEST
VERIFIED UPLOAD. (100% SCORE).
62-year-old woman - osteoporosis - a bisphosphonate is prescribed. The expected beneficial
effect of the drug is due to which of the following? -CORRECT ANS>> Decreased Osteoclast
Activity
Cohot Study of elderly women - relative risk ratio for hip fractures among those who exercise
regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the conclusion
about the effect of exercise on the risk of hip fracture? -CORRECT ANS>> Statistically Significant
Overall Increase Risk
52-year-old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse is
80/min and blood pressure is 130/70. The most immediate treatment mechanism of action? -
CORRECT ANS>> Increased nitric oxide concentration
24-year-old woman - spilled hot grease on her left leg while working at a fast-food restaurant.
Exam of leg shows 7cm pink, soft, granular, edematous wound. The formation of this tissue was
most likely caused by increased activity of which? -CORRECT ANS>> a.
Vascular Endothelial Growth Factor VEGF - stimulates angiogenesis.
TYPE III Collagen = Blood Vessels - early wound repair
27-year-old man- MVC - skull x-ray shows a linear, nondepressed basal skull fracture - increased
serum osm and decreased urin osm. Following desmopressin urine osm increases.
Desmopressin's effect is due to the activation of which of the following? -CORRECT ANS>> a.
Adenylyl Cyclase
Adenylate Cyclase - ATP - CAMP -- PROTEKINASE A -- Ca v2
A 10-month-old boy - 4-day history of fever and cough. He attends day care center. Chest exam
shows intercostal retractions along with bilateral, diffuse wheezes and expiratory rhonchi. The
infectious agent most likely has which of the following properties? -CORRECT ANS>> Mediation
of Cell Entry via a fusion protein
A 17-year-old girl in ED - 15 minutes after being stung by a bee. Mild light headedness but no
difficulty swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy for this
patient? -CORRECT ANS>> B2- Agonist
14-year-old boy - 2-day history of sore throat and fever that peaks in late afternoon. 1 week of
fatigue. He recently had sex with one partner. Physical exam shows cervical lymphadenopathy
and pharyngeal erythema with a creamy exudate. DX? -CORRECT ANS>> Infectious
Mononucleosis
, 57-year-old man - radiation therapy for squamous cell carcinoma of the lung. Despite therapy,
tumor increases in size and he dies 6 months later. The progressive tumor growth is due to a
defect in cell cycle arrest in which of the following phases of cell cycle? -CORRECT ANS>> G1
28-year-old - lived in sub-Saharan Africa - until he came to the US. Temp of 100.4 - imaging
shows bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered
granulomas. DX? -CORRECT ANS>> Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and man has two
gene deletion. If the two gene is trans - what percentage of offspring will have a two gene
deletion? -CORRECT ANS>> 50%
previously healthy 40 year brought to emergency department by her husband - 2-day history of
fever, lethargy, confusion. PE shows scattered petechiae and ecchymoses over the lower
extremities - 3+ polychromasia and 3+ schistocytes and Low platelets Dx? -CORRECT ANS>>
Thrombotic Thrombocytopenia Purpura
49-year-old woman - coronary artery disease - BP 140/90 - High Cholesterol, High LDL (190),
High triglycerides (350) - TX with atorvastatin and losartan. What are the effects on HDL and
Triglycerides? -CORRECT ANS>> HDL increased
Triglycerides Decreased
73-year-old - diffuse weakness and tingling of her arms and legs. Sensation and vibration and
position is decreased in all extremities. What vitamin deficiency? -CORRECT ANS>> Vitamin B12
- (cyanocobalamin)
Tea and Toast - low B12 in diet
15-year-old girl - 3-month history of acne - which is the underlying cause of the patient’s acne? -
CORRECT ANS>> Stimulation of Sebaceous Glands by androgens
b. ACNE = Propionibacterium ACNE
4-year-old from Brazil - PE shows single 12x10cm lesion in the right side of jaw with diffuse
regular edges. Photomicrographs of an incisional biopsy (looks like Burkitt’s Lymphoma/ Starry
night) - which of the processes most likely to occur in the region indicated by the arrow? -
CORRECT ANS>> Apoptosis
b. Endemic Burkitt lymphoma can happen in Brazil as well as Africa (jaw lesion, puffy face).
51-year-old - lump on tongue - 1 pack smoking history for 30 years. 1.5 cm mass on apex of
tongue. It is most appropriate to evaluate which lymph nodes first for evidence of metastasis? -
CORRECT ANS>> Submental
15-year-old boy - ER - 2-hour history of confusion and agitation - fever, headache, stiff neck, and
vomiting - since returned from summer camp - patient is hallucinating - lumbar puncture - shows
cysts and trophozoites- most likely pathogen? -CORRECT ANS>> a. Olfactory Nerve
Naegleria fowleri
QUESTIONS AND ANSWERS. LATEST
VERIFIED UPLOAD. (100% SCORE).
62-year-old woman - osteoporosis - a bisphosphonate is prescribed. The expected beneficial
effect of the drug is due to which of the following? -CORRECT ANS>> Decreased Osteoclast
Activity
Cohot Study of elderly women - relative risk ratio for hip fractures among those who exercise
regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the conclusion
about the effect of exercise on the risk of hip fracture? -CORRECT ANS>> Statistically Significant
Overall Increase Risk
52-year-old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse is
80/min and blood pressure is 130/70. The most immediate treatment mechanism of action? -
CORRECT ANS>> Increased nitric oxide concentration
24-year-old woman - spilled hot grease on her left leg while working at a fast-food restaurant.
Exam of leg shows 7cm pink, soft, granular, edematous wound. The formation of this tissue was
most likely caused by increased activity of which? -CORRECT ANS>> a.
Vascular Endothelial Growth Factor VEGF - stimulates angiogenesis.
TYPE III Collagen = Blood Vessels - early wound repair
27-year-old man- MVC - skull x-ray shows a linear, nondepressed basal skull fracture - increased
serum osm and decreased urin osm. Following desmopressin urine osm increases.
Desmopressin's effect is due to the activation of which of the following? -CORRECT ANS>> a.
Adenylyl Cyclase
Adenylate Cyclase - ATP - CAMP -- PROTEKINASE A -- Ca v2
A 10-month-old boy - 4-day history of fever and cough. He attends day care center. Chest exam
shows intercostal retractions along with bilateral, diffuse wheezes and expiratory rhonchi. The
infectious agent most likely has which of the following properties? -CORRECT ANS>> Mediation
of Cell Entry via a fusion protein
A 17-year-old girl in ED - 15 minutes after being stung by a bee. Mild light headedness but no
difficulty swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy for this
patient? -CORRECT ANS>> B2- Agonist
14-year-old boy - 2-day history of sore throat and fever that peaks in late afternoon. 1 week of
fatigue. He recently had sex with one partner. Physical exam shows cervical lymphadenopathy
and pharyngeal erythema with a creamy exudate. DX? -CORRECT ANS>> Infectious
Mononucleosis
, 57-year-old man - radiation therapy for squamous cell carcinoma of the lung. Despite therapy,
tumor increases in size and he dies 6 months later. The progressive tumor growth is due to a
defect in cell cycle arrest in which of the following phases of cell cycle? -CORRECT ANS>> G1
28-year-old - lived in sub-Saharan Africa - until he came to the US. Temp of 100.4 - imaging
shows bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered
granulomas. DX? -CORRECT ANS>> Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and man has two
gene deletion. If the two gene is trans - what percentage of offspring will have a two gene
deletion? -CORRECT ANS>> 50%
previously healthy 40 year brought to emergency department by her husband - 2-day history of
fever, lethargy, confusion. PE shows scattered petechiae and ecchymoses over the lower
extremities - 3+ polychromasia and 3+ schistocytes and Low platelets Dx? -CORRECT ANS>>
Thrombotic Thrombocytopenia Purpura
49-year-old woman - coronary artery disease - BP 140/90 - High Cholesterol, High LDL (190),
High triglycerides (350) - TX with atorvastatin and losartan. What are the effects on HDL and
Triglycerides? -CORRECT ANS>> HDL increased
Triglycerides Decreased
73-year-old - diffuse weakness and tingling of her arms and legs. Sensation and vibration and
position is decreased in all extremities. What vitamin deficiency? -CORRECT ANS>> Vitamin B12
- (cyanocobalamin)
Tea and Toast - low B12 in diet
15-year-old girl - 3-month history of acne - which is the underlying cause of the patient’s acne? -
CORRECT ANS>> Stimulation of Sebaceous Glands by androgens
b. ACNE = Propionibacterium ACNE
4-year-old from Brazil - PE shows single 12x10cm lesion in the right side of jaw with diffuse
regular edges. Photomicrographs of an incisional biopsy (looks like Burkitt’s Lymphoma/ Starry
night) - which of the processes most likely to occur in the region indicated by the arrow? -
CORRECT ANS>> Apoptosis
b. Endemic Burkitt lymphoma can happen in Brazil as well as Africa (jaw lesion, puffy face).
51-year-old - lump on tongue - 1 pack smoking history for 30 years. 1.5 cm mass on apex of
tongue. It is most appropriate to evaluate which lymph nodes first for evidence of metastasis? -
CORRECT ANS>> Submental
15-year-old boy - ER - 2-hour history of confusion and agitation - fever, headache, stiff neck, and
vomiting - since returned from summer camp - patient is hallucinating - lumbar puncture - shows
cysts and trophozoites- most likely pathogen? -CORRECT ANS>> a. Olfactory Nerve
Naegleria fowleri
