Midterm Exam - NURS6521 / NURS
6521 (Latest ) : Advanced
Pharmacology - Walden
Questions 1–50: NURS6521 Advanced Pharmacology
Midterm Exam
Pharmacotherapeutics and Pharmacokinetics
1. What is the primary goal of pharmacotherapeutics?
A. To study drug metabolism
B. To achieve therapeutic effects with minimal adverse effects
C. To increase drug absorption
D. To reduce drug excretion
Answer: To achieve therapeutic effects with minimal adverse effects
Rationale: Pharmacotherapeutics focuses on using drugs to treat conditions effectively
while minimizing harm.
2. A patient is prescribed a drug with a high first-pass effect. What does this imply?
A. The drug is ineffective orally
B. A higher oral dose is needed due to liver metabolism
C. The drug is only given intravenously
D. The drug has no side effects
Answer: A higher oral dose is needed due to liver metabolism
Rationale: A high first-pass effect means significant drug metabolism in the liver,
requiring a higher oral dose to achieve therapeutic levels.
3. Which factor affects drug absorption? (Select all that apply)
A. Gastrointestinal motility
B. Route of administration
C. Blood glucose levels
D. Patient’s age
E. Drug solubility
Answer: Gastrointestinal motility, Route of administration, Patient’s age, Drug
solubility
Rationale: Absorption is influenced by GI motility, administration route, age-related
changes, and drug solubility. Blood glucose is unrelated.
, 4. What is the primary concern when administering a Schedule II drug like morphine?
A. Low therapeutic index
B. High abuse potential
C. Short half-life
D. Minimal side effects
Answer: High abuse potential
Rationale: Schedule II drugs like morphine have a high potential for abuse and
dependence, requiring careful monitoring.,
5. What is the half-life of a drug?
A. Time to reach peak plasma concentration
B. Time for the drug concentration to reduce by half
C. Time for complete drug elimination
D. Time for the drug to start working
Answer: Time for the drug concentration to reduce by half
Rationale: Half-life is the time required for the drug’s plasma concentration to decrease
by 50%, affecting dosing frequency.
Cardiovascular Pharmacology
6. What is the first-line treatment for hypertension in a patient with diabetes and
microalbuminuria?
A. Hydrochlorothiazide
B. Metoprolol
C. Lisinopril
D. Amlodipine
Answer: Lisinopril
Rationale: ACE inhibitors like lisinopril are first-line for hypertension in diabetic
patients with microalbuminuria due to renal protective effects.
7. A patient on warfarin is prescribed etoposide. What should the nurse monitor?
A. Blood glucose
B. Prothrombin time (PT/INR)
C. Serum potassium
D. Blood pressure
Answer: Prothrombin time (PT/INR)
Rationale: Etoposide can enhance warfarin’s anticoagulant effect, increasing bleeding
risk, so PT/INR must be monitored.,
8. What is a common side effect of sildenafil (Viagra)?
A. Weight gain
B. Flushing or headache
6521 (Latest ) : Advanced
Pharmacology - Walden
Questions 1–50: NURS6521 Advanced Pharmacology
Midterm Exam
Pharmacotherapeutics and Pharmacokinetics
1. What is the primary goal of pharmacotherapeutics?
A. To study drug metabolism
B. To achieve therapeutic effects with minimal adverse effects
C. To increase drug absorption
D. To reduce drug excretion
Answer: To achieve therapeutic effects with minimal adverse effects
Rationale: Pharmacotherapeutics focuses on using drugs to treat conditions effectively
while minimizing harm.
2. A patient is prescribed a drug with a high first-pass effect. What does this imply?
A. The drug is ineffective orally
B. A higher oral dose is needed due to liver metabolism
C. The drug is only given intravenously
D. The drug has no side effects
Answer: A higher oral dose is needed due to liver metabolism
Rationale: A high first-pass effect means significant drug metabolism in the liver,
requiring a higher oral dose to achieve therapeutic levels.
3. Which factor affects drug absorption? (Select all that apply)
A. Gastrointestinal motility
B. Route of administration
C. Blood glucose levels
D. Patient’s age
E. Drug solubility
Answer: Gastrointestinal motility, Route of administration, Patient’s age, Drug
solubility
Rationale: Absorption is influenced by GI motility, administration route, age-related
changes, and drug solubility. Blood glucose is unrelated.
, 4. What is the primary concern when administering a Schedule II drug like morphine?
A. Low therapeutic index
B. High abuse potential
C. Short half-life
D. Minimal side effects
Answer: High abuse potential
Rationale: Schedule II drugs like morphine have a high potential for abuse and
dependence, requiring careful monitoring.,
5. What is the half-life of a drug?
A. Time to reach peak plasma concentration
B. Time for the drug concentration to reduce by half
C. Time for complete drug elimination
D. Time for the drug to start working
Answer: Time for the drug concentration to reduce by half
Rationale: Half-life is the time required for the drug’s plasma concentration to decrease
by 50%, affecting dosing frequency.
Cardiovascular Pharmacology
6. What is the first-line treatment for hypertension in a patient with diabetes and
microalbuminuria?
A. Hydrochlorothiazide
B. Metoprolol
C. Lisinopril
D. Amlodipine
Answer: Lisinopril
Rationale: ACE inhibitors like lisinopril are first-line for hypertension in diabetic
patients with microalbuminuria due to renal protective effects.
7. A patient on warfarin is prescribed etoposide. What should the nurse monitor?
A. Blood glucose
B. Prothrombin time (PT/INR)
C. Serum potassium
D. Blood pressure
Answer: Prothrombin time (PT/INR)
Rationale: Etoposide can enhance warfarin’s anticoagulant effect, increasing bleeding
risk, so PT/INR must be monitored.,
8. What is a common side effect of sildenafil (Viagra)?
A. Weight gain
B. Flushing or headache
