GMS 6121 Exam 1 Module 1.4
questions well answered to pass
the process by which one organism causes disease in another
indirect consequence of propagation
not a common consequence, majority are subclinical
2 components:
1. effects of virus REPLICATION on the host
2. effects of host RESPONSE on virus and the host - correct answer ✔✔What is viral
pathogenesis?
understand interaction of viruses with host cells, one can identify antiviral drug targets
can understand how immune system targets
identify virulence factors or antigenic epitopes, design effective vaccines - correct answer
✔✔why study pathogenesis?
targets influenza neuraminidase, inhibits
permissive cell = supports influenza infection
, after budding to leave host cell, virion remains stuck, encodes neuraminidase to cleave sialic
acid and release
tamiflu binds neuraminidase so virions cannot spread - correct answer ✔✔What is tamiflu?
anywhere they can come into contact with host from external environment
skin
eyes (conjunctiva)
along any exposed mucosal surfaces = GI, urogenital, resp - correct answer ✔✔What are points
of viral entry?
multilayer epithelium
most exposed comprised of dead keratin, so virus cannot replicate
in order to infect, must break/puncture to reach live layers = needle punctures, abrasions,
insect/animal bites
severity depends on how deep virus is deposited
upper layer is devoid of lymphatics or blood vessels, stays confined
lower layers are highly vascularized
ex. herpes-, pox-, papilloma-, arbo- viruses (carried in insect vector) - correct answer
✔✔Describe the skin as a barrier
questions well answered to pass
the process by which one organism causes disease in another
indirect consequence of propagation
not a common consequence, majority are subclinical
2 components:
1. effects of virus REPLICATION on the host
2. effects of host RESPONSE on virus and the host - correct answer ✔✔What is viral
pathogenesis?
understand interaction of viruses with host cells, one can identify antiviral drug targets
can understand how immune system targets
identify virulence factors or antigenic epitopes, design effective vaccines - correct answer
✔✔why study pathogenesis?
targets influenza neuraminidase, inhibits
permissive cell = supports influenza infection
, after budding to leave host cell, virion remains stuck, encodes neuraminidase to cleave sialic
acid and release
tamiflu binds neuraminidase so virions cannot spread - correct answer ✔✔What is tamiflu?
anywhere they can come into contact with host from external environment
skin
eyes (conjunctiva)
along any exposed mucosal surfaces = GI, urogenital, resp - correct answer ✔✔What are points
of viral entry?
multilayer epithelium
most exposed comprised of dead keratin, so virus cannot replicate
in order to infect, must break/puncture to reach live layers = needle punctures, abrasions,
insect/animal bites
severity depends on how deep virus is deposited
upper layer is devoid of lymphatics or blood vessels, stays confined
lower layers are highly vascularized
ex. herpes-, pox-, papilloma-, arbo- viruses (carried in insect vector) - correct answer
✔✔Describe the skin as a barrier
