WGU D115
WGU D115 Master Set-Advanced Pathophysiology
for the Advanced Practice Nurse 2025
Which type of genetic disease affects males more frequently than females? -
Correct Answer ✔Sex-Linked recessive. Since males only have one X and one Y,
if the affected chromosome has the illness, it will be expressed.
In which two conditions are chromosomal abnormalities the leading known cause?
-Correct Answer ✔Intellectual disability and fetal miscarriage. Chromosome
abnormalities are the leading known cause of intellectual disability and fetal
miscarriage.
What are three examples of prenatal diagnostic studies? -Correct Answer
✔Chorionic villus sampling (CVS), amniocentesis, and preimplantation genetic
testing (PGT) are examples of prenatal diagnostic studies and are performed in
vitro. CVS is a form of genetic testing that provides genetic information found in
utero and is usually performed between weeks 11 and 14 of pregnancy. An
amniocentesis is a form of genetic testing that evaluates amniotic fluid and is
usually performed during the second trimester, between weeks 15 and 20 of
pregnancy. PGT is performed on the embryo prior to implantation.
Which genetic disorder is characterized by the presence of a zygote having one
chromosome with a normal complement of genes and one chromosome with a
missing gene? -Correct Answer ✔Cri du chat syndrome (translated as "cry of the
cat") is caused by a DNA deletion. This term describes the cry often heard from a
baby affected by the syndrome. Cri du chat syndrome can present as a
microcephalic, low birth-weight baby with a piercing cry.
How can an X-linked recessive disease skip generations? -Correct Answer ✔The
disease can be transmitted through female carriers.
Since females have two copies of the X chromosome, the mother may provide an
unaffected X to a daughter or son. Furthermore, a daughter may not show signs of
WGU D115
,WGU D115
the disease because she has the other X (the only X the father can give to a female)
to cancel it out.
Which type of risk is referred to as the ratio of the disease rate among the entire
population to the disease rate in an unexposed population? -Correct Answer
✔Relative risk is a ratio of probability, not an actual occurrence of disease.
What are the empirical risks for most multifactorial diseases based on? -Correct
Answer ✔Many factors from lifestyle to genetics affect multifactorial diseases.
Observation and evaluation of each case individually provides the most thorough
and accurate assessment.
What refers to the silenced gene of a gene pair. -Correct Answer ✔The imprinted
gene is the silent gene of a gene pair.
What is the primary reason that some older adults have impaired inflammation and
wound healing? -Correct Answer ✔The underlying chronic illness exists.
A generalized inflammatory response seen in chronic illness depletes the body's
reserves to fight against illness.
Which cells are the body's primary defense against parasite invasion? -Correct
Answer ✔Eosinophils are the body's primary defense against parasites.
What Phagocytes bacteria? -Correct Answer ✔Macrophages work by eating or
phagocytosing bacteria.
What is the first response to a foreign pathogen? -Correct Answer ✔Helper T cells
Which characteristic is the most important determinant of immunogenicity when
considering the antigen? -Correct Answer ✔Immunogenicity is primarily based on
the ability to recognize something foreign.
WGU D115
,WGU D115
How are erythrocytes destroyed when mismatched blood is administered, causing
an ABO incompatibility? -Correct Answer ✔The complement pathway is activated
in response to blood incompatibility.
What is the hypersensitivity reaction that causes atopic dermatitis? -Correct
Answer ✔An immediate (type I) hypersensitivity reaction causes atopic dermatitis.
Which four infections are considered fungal infections? -Correct Answer
✔Infection with a fungus is called mycosis and includes dermatophytes (e.g.,
tineas, which refers to several skin mycoses, including ringworm and athlete's foot)
and yeasts, which include candida and aspergillus.
When is the earliest after sexual transmission of HIV that lab results can detect
infection? -Correct Answer ✔Lab testing can detect HIV RNA 4 to 10 days after
sexual transmission, whereas HIV antibody testing may take 23 to 90 days to result
in a positive test. Repeat testing may be needed to rule out a false negative test due
to testing too soon after exposure, especially if a high likelihood of exposure is
suspected.
What is a characteristic of exotoxins? -Correct Answer ✔Exotoxins are released
during bacterial growth.
Which dietary lifestyle choice has been associated with a decreased risk for
developing colon cancer? -Correct Answer ✔The results of decreased fat
consumption have been widely studied and have demonstrated a decreased risk of
developing colon cancer.
Which cancer is an individual who has worked with asbestos for over 40 years
most likely to develop? -Correct Answer ✔Asbestos exposure results in an
increased risk of lung and lung lining cancer.
Which statement is true regarding ultraviolet (UV) light?
WGU D115
, WGU D115
The degree of damage is not affected by the light's wavelength. -Correct Answer
✔UV light causes basal cell carcinoma and squamous cell carcinoma when the
UVB rays hit DNA strands, causing thymine base pairs that are side by side to pair
together, becoming thymine dimers. These thymine dimers lead to cell death or
cancer.
Which cancer does exercise have a convincing impact on reducing? -Correct
Answer ✔Exercise-induced myokines cause apoptosis of colon cancer cells.
Low healthcare literacy is recognized as a major risk factor in blood pressure
control and has been shown to have adverse effects on health outcomes.
true or false -Correct Answer ✔TRUE
By providing patient education at the appropriate literacy level, improved health
outcomes may result.
One of the goals of the National Action Plan to Improve Health Literacy is to
incorporate research and evidence-based plans of treatment from childhood
through university-level education in a manner consistent with an individual's
literacy level.
True or false -Correct Answer ✔True
Ensuring the individual can understand all elements of a treatment plan is crucial
for understanding and compliance.
What is a red flag for low healthcare literacy? -Correct Answer ✔Low literacy
often leads to perceived noncompliance to medical instructions, including
medication instructions. Ensuring the patient fully understands all instructions is
critical for understanding.
Amniocentesis is recommended for pregnant women with certain health histories.
Which health history would result in an amniocentesis recommendation? -Correct
Answer ✔Those who have a family history of genetic disorders
Studies have identified several genes that play a role in the prevention of obesity.
WGU D115
WGU D115 Master Set-Advanced Pathophysiology
for the Advanced Practice Nurse 2025
Which type of genetic disease affects males more frequently than females? -
Correct Answer ✔Sex-Linked recessive. Since males only have one X and one Y,
if the affected chromosome has the illness, it will be expressed.
In which two conditions are chromosomal abnormalities the leading known cause?
-Correct Answer ✔Intellectual disability and fetal miscarriage. Chromosome
abnormalities are the leading known cause of intellectual disability and fetal
miscarriage.
What are three examples of prenatal diagnostic studies? -Correct Answer
✔Chorionic villus sampling (CVS), amniocentesis, and preimplantation genetic
testing (PGT) are examples of prenatal diagnostic studies and are performed in
vitro. CVS is a form of genetic testing that provides genetic information found in
utero and is usually performed between weeks 11 and 14 of pregnancy. An
amniocentesis is a form of genetic testing that evaluates amniotic fluid and is
usually performed during the second trimester, between weeks 15 and 20 of
pregnancy. PGT is performed on the embryo prior to implantation.
Which genetic disorder is characterized by the presence of a zygote having one
chromosome with a normal complement of genes and one chromosome with a
missing gene? -Correct Answer ✔Cri du chat syndrome (translated as "cry of the
cat") is caused by a DNA deletion. This term describes the cry often heard from a
baby affected by the syndrome. Cri du chat syndrome can present as a
microcephalic, low birth-weight baby with a piercing cry.
How can an X-linked recessive disease skip generations? -Correct Answer ✔The
disease can be transmitted through female carriers.
Since females have two copies of the X chromosome, the mother may provide an
unaffected X to a daughter or son. Furthermore, a daughter may not show signs of
WGU D115
,WGU D115
the disease because she has the other X (the only X the father can give to a female)
to cancel it out.
Which type of risk is referred to as the ratio of the disease rate among the entire
population to the disease rate in an unexposed population? -Correct Answer
✔Relative risk is a ratio of probability, not an actual occurrence of disease.
What are the empirical risks for most multifactorial diseases based on? -Correct
Answer ✔Many factors from lifestyle to genetics affect multifactorial diseases.
Observation and evaluation of each case individually provides the most thorough
and accurate assessment.
What refers to the silenced gene of a gene pair. -Correct Answer ✔The imprinted
gene is the silent gene of a gene pair.
What is the primary reason that some older adults have impaired inflammation and
wound healing? -Correct Answer ✔The underlying chronic illness exists.
A generalized inflammatory response seen in chronic illness depletes the body's
reserves to fight against illness.
Which cells are the body's primary defense against parasite invasion? -Correct
Answer ✔Eosinophils are the body's primary defense against parasites.
What Phagocytes bacteria? -Correct Answer ✔Macrophages work by eating or
phagocytosing bacteria.
What is the first response to a foreign pathogen? -Correct Answer ✔Helper T cells
Which characteristic is the most important determinant of immunogenicity when
considering the antigen? -Correct Answer ✔Immunogenicity is primarily based on
the ability to recognize something foreign.
WGU D115
,WGU D115
How are erythrocytes destroyed when mismatched blood is administered, causing
an ABO incompatibility? -Correct Answer ✔The complement pathway is activated
in response to blood incompatibility.
What is the hypersensitivity reaction that causes atopic dermatitis? -Correct
Answer ✔An immediate (type I) hypersensitivity reaction causes atopic dermatitis.
Which four infections are considered fungal infections? -Correct Answer
✔Infection with a fungus is called mycosis and includes dermatophytes (e.g.,
tineas, which refers to several skin mycoses, including ringworm and athlete's foot)
and yeasts, which include candida and aspergillus.
When is the earliest after sexual transmission of HIV that lab results can detect
infection? -Correct Answer ✔Lab testing can detect HIV RNA 4 to 10 days after
sexual transmission, whereas HIV antibody testing may take 23 to 90 days to result
in a positive test. Repeat testing may be needed to rule out a false negative test due
to testing too soon after exposure, especially if a high likelihood of exposure is
suspected.
What is a characteristic of exotoxins? -Correct Answer ✔Exotoxins are released
during bacterial growth.
Which dietary lifestyle choice has been associated with a decreased risk for
developing colon cancer? -Correct Answer ✔The results of decreased fat
consumption have been widely studied and have demonstrated a decreased risk of
developing colon cancer.
Which cancer is an individual who has worked with asbestos for over 40 years
most likely to develop? -Correct Answer ✔Asbestos exposure results in an
increased risk of lung and lung lining cancer.
Which statement is true regarding ultraviolet (UV) light?
WGU D115
, WGU D115
The degree of damage is not affected by the light's wavelength. -Correct Answer
✔UV light causes basal cell carcinoma and squamous cell carcinoma when the
UVB rays hit DNA strands, causing thymine base pairs that are side by side to pair
together, becoming thymine dimers. These thymine dimers lead to cell death or
cancer.
Which cancer does exercise have a convincing impact on reducing? -Correct
Answer ✔Exercise-induced myokines cause apoptosis of colon cancer cells.
Low healthcare literacy is recognized as a major risk factor in blood pressure
control and has been shown to have adverse effects on health outcomes.
true or false -Correct Answer ✔TRUE
By providing patient education at the appropriate literacy level, improved health
outcomes may result.
One of the goals of the National Action Plan to Improve Health Literacy is to
incorporate research and evidence-based plans of treatment from childhood
through university-level education in a manner consistent with an individual's
literacy level.
True or false -Correct Answer ✔True
Ensuring the individual can understand all elements of a treatment plan is crucial
for understanding and compliance.
What is a red flag for low healthcare literacy? -Correct Answer ✔Low literacy
often leads to perceived noncompliance to medical instructions, including
medication instructions. Ensuring the patient fully understands all instructions is
critical for understanding.
Amniocentesis is recommended for pregnant women with certain health histories.
Which health history would result in an amniocentesis recommendation? -Correct
Answer ✔Those who have a family history of genetic disorders
Studies have identified several genes that play a role in the prevention of obesity.
WGU D115
