2025/2026 AGACNP Infectious Disease Review – 100 Solved Q&As | Sepsis, Pneumonia, Meningitis, UTIs, Endocarditis, HIV, COVID-19 & More

This in-depth infectious disease study guide is tailored for the 2025/2026 Adult-Gerontology Acute Care Nurse Practitioner (AGACNP) certification exam, featuring 100 fully solved, exam-ready questions and answers with high clinical relevance. Built on evidence-based standards, this document prepares nurse practitioner students for both board exams and real-world acute care scenarios involving infectious disease emergencies and management protocols. Key topics and content areas include: Sepsis Management: qSOFA criteria, fluid resuscitation, vasopressor initiation, and early empiric antibiotic use Pneumonia (CAP, HAP, VAP): pathogens, empiric therapy choices (e.g., ceftriaxone, azithromycin, vanco, cefepime), and ICU-specific risks Opportunistic Infections: PCP pneumonia, toxoplasmosis, MAC, and prophylaxis strategies by CD4 count in HIV patients CNS Infections: bacterial and viral meningitis (e.g., LP findings, empiric therapy, signs of ↑ ICP), HSV coverage, and acyclovir indications UTIs and Pyelonephritis: simple vs complicated infections, antibiotic selection (TMP-SMX, ciprofloxacin), and admission criteria Skin and Soft Tissue Infections: cellulitis, necrotizing fasciitis, diabetic foot infections, antibiotic combinations, and surgical urgency Endocarditis: risk factors (e.g., IV drug use, prosthetic valves), signs (Janeway lesions, murmurs), diagnostics (TEE), and IV antibiotic protocols HIV & Viral Infections: universal screening, prophylaxis by CD4 levels, and current COVID-19 recommendations (e.g., dexamethasone, remdesivir) Pharmacology Focus: MRSA, Pseudomonas, anaerobic coverage, and antibiotics with no renal dosing adjustment This study guide is ideal for reinforcing both foundational knowledge and advanced decision-making. The structure is perfect for rapid recall, concept reinforcement, and timed test preparation. Who this document is for: MSN and DNP students preparing for the AGACNP board exams with a focus on infectious disease Nurse practitioner candidates reviewing ID-specific topics for AACN or ANCC certification Hospital-based NPs or residents managing septic, immunocompromised, or infected patients in acute care units Clinical instructors teaching infectious disease protocols or case-based simulation Keywords: AGACNP infectious disease review, sepsis protocol, qSOFA criteria, pneumonia treatment, MRSA coverage, bacterial meningitis CSF, HIV prophylaxis, COVID-19 ARDS, TMP-SMX dosing, necrotizing fasciitis, diabetic foot infection, endocarditis signs, TEE diagnosis, Pseudomonas therapy, no renal dose adjustment antibiotics, viral meningitis, urinary tract infection, PCP pneumonia