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2025/2026 AGACNP Exam Review – 120 Board-Style Questions with Answers | Endocrine, Neuro, Cardio, Pulmonary & More

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This expertly compiled AGACNP review guide for the 2025/2026 exam cycle includes 120 high-yield, board-style questions with thoroughly explained answers and rationales. Designed for Adult-Gerontology Acute Care Nurse Practitioner (AGACNP) students preparing for AACN certification or recertification, this document systematically covers essential clinical topics including endocrine disorders (e.g., Cushing’s, Addison’s), neurological emergencies (e.g., SAH, hematomas, meningitis), cardiology (murmur identification, valve pathologies, heart failure), pulmonary conditions (pleural effusions, pulmonary hypertension), and fluid/electrolyte imbalances (e.g., SIADH, DI). Each question is paired with concise, evidence-based answers and clinical reasoning to promote understanding and exam readiness. The format mirrors the AACN certification exam to help students practice clinical decision-making in realistic scenarios. Additional diagnostic clues and test interpretation (e.g., Dexamethasone suppression test, opening pressure in meningitis) are also included, making this a complete study tool. This resource is ideal for: AGACNP students in MSN, DNP, or post-master’s certificate programs Adult-Gerontology Primary Care NP students seeking acute care crossover knowledge Critical care nurses, clinical nurse specialists, or nurse educators preparing for AGACNP board exams Students in advanced pharmacology, pathophysiology, or adult acute care rotations Keywords: AGACNP exam questions, AACN board review, 2025 AGACNP study guide, acute care NP exam prep, nurse practitioner certification, Cushing’s syndrome, Addison’s disease, meningitis signs, subarachnoid hemorrhage, cardiac murmurs, pleural effusion types, diabetes insipidus, SIADH, ACL tear test, mitral regurgitation, physiologic murmurs

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AACN AGACNP

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AACN AGACNP Review 2025/2026 Exam
Questions and Detailed Answers | Get it
100% Correct Answers



Cushing's Syndrome/Disease - 🧠 ANSWER ✔✔cortisol excess typically caused by

pituitary adenoma 60-70% of cases.




Central obesity w/ extremity wasting.

dorsocervical fat pad.

rounded facies.

spontaneous bruising.

purple striae

hyperpigmentation

, poor wound healing/ skin infections.




Dexamethasone suppression test.

1mg dexamethasone at 2300 hours and measure serum cortisol at 0800.




Remove sources of excess and manage consequences ( HTN, hypokalemia,

hyperglycemia.)


Addison's disease - 🧠 ANSWER ✔✔Primary


Caused by damage to the adrenal cortex (autoimmune, TB, metastatic disease,

deposition diseases, and drug induced) leading to a decrease in cortisol production.




Secondary

Caused by pituitary failure to release ACTH (in any hypopituitary disorder)

causing a decrease in cortisol production.

Sudden withdrawal of systemic corticosteroids leading to a decrease in cortisol

production from induced corticosteroid suppression.
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