NURS 6521 Final Exam Bundle
Advanced Pharmacology – 100 Questions
with Rationales
Institution: Walden University
Course: NURS 6521 – Advanced Pharmacology
Format: NCLEX-style, Multiple Choice
Includes:
• 100 Practice Questions
• Detailed Answer Rationales
• Midterm & Final Exam Topics
• Bonus High-Yield Mini Review
Updated: July 2025
Created for: Nurse Practitioner & MSN Students
Prepared by: Advanced Practice Student Contributor
Table of Contents
Section Description Questions
Part 1 Pharmacokinetics, Antibiotics, Cardiovascular Meds 1–25
Part 2 Respiratory, Psych, Endocrine, GI Meds 26–50
Part 3 Pregnancy, Special Populations, Antivirals, Anticoagulants 51–75
Part 4 Neuro, Anti-inflammatory, Black Box Warnings, Toxicities 76–100
Bonus High-Yield Rapid Review: 10 Extra Facts 91–100
All the best!!
1. Which of the following best describes the mechanism of action of beta-blockers?
A. Decrease cardiac output by stimulating beta receptors
B. Inhibit beta-adrenergic receptors, reducing heart rate and contractility
,C. Stimulate alpha-1 receptors causing vasodilation
D. Increase peripheral resistance and cardiac output
Answer: B
Beta-blockers block beta-adrenergic receptors, leading to decreased heart rate, blood pressure, and
myocardial oxygen demand.
2. ACE inhibitors lower blood pressure by:
A. Direct vasodilation of arterioles
B. Blocking angiotensin I conversion to angiotensin II
C. Increasing norepinephrine release
D. Stimulating aldosterone secretion
Answer: B
ACE inhibitors prevent angiotensin II formation, decreasing vasoconstriction and aldosterone-
mediated sodium retention.
3. A serious side effect of ACE inhibitors is:
A. Constipation
B. Hyperkalemia
C. Tachycardia
D. Hypernatremia
Answer: B
ACE inhibitors decrease aldosterone, which can lead to potassium retention and hyperkalemia.
4. A patient on warfarin should avoid which of the following?
A. High-protein diets
B. Spinach and broccoli
C. Dairy products
D. Citrus fruits
Answer: B
Green leafy vegetables are high in vitamin K, which antagonizes warfarin's anticoagulant effect.
5. Which insulin has the fastest onset of action?
A. NPH
B. Regular
C. Glargine
D. Lispro
Answer: D
, Insulin lispro is rapid-acting, with onset in 10–15 minutes.
6. Black box warning for fluoroquinolones includes:
A. Hepatic failure
B. Tendon rupture
C. Cardiac arrhythmia
D. Nephrotoxicity
Answer: B
Fluoroquinolones (e.g., ciprofloxacin) are associated with tendonitis and tendon rupture.
7. First-line treatment for hypertension in African American adults without CKD is:
A. ACE inhibitor
B. Beta-blocker
C. Thiazide diuretic or CCB
D. ARB
Answer: C
Thiazide diuretics or calcium channel blockers are first-line per JNC-8 guidelines.
8. Metformin is contraindicated in:
A. Type 2 diabetes
B. Pregnancy
C. Renal insufficiency
D. Obesity
Answer: C
Metformin is excreted renally; accumulation increases risk for lactic acidosis.
9. Statins primarily work by:
A. Blocking fat absorption
B. Inhibiting HMG-CoA reductase
C. Increasing HDL clearance
D. Blocking cholesterol reabsorption
Answer: B
Statins inhibit the HMG-CoA reductase enzyme, which reduces cholesterol synthesis in the liver.
10. Which antihypertensive is safe in pregnancy?
Advanced Pharmacology – 100 Questions
with Rationales
Institution: Walden University
Course: NURS 6521 – Advanced Pharmacology
Format: NCLEX-style, Multiple Choice
Includes:
• 100 Practice Questions
• Detailed Answer Rationales
• Midterm & Final Exam Topics
• Bonus High-Yield Mini Review
Updated: July 2025
Created for: Nurse Practitioner & MSN Students
Prepared by: Advanced Practice Student Contributor
Table of Contents
Section Description Questions
Part 1 Pharmacokinetics, Antibiotics, Cardiovascular Meds 1–25
Part 2 Respiratory, Psych, Endocrine, GI Meds 26–50
Part 3 Pregnancy, Special Populations, Antivirals, Anticoagulants 51–75
Part 4 Neuro, Anti-inflammatory, Black Box Warnings, Toxicities 76–100
Bonus High-Yield Rapid Review: 10 Extra Facts 91–100
All the best!!
1. Which of the following best describes the mechanism of action of beta-blockers?
A. Decrease cardiac output by stimulating beta receptors
B. Inhibit beta-adrenergic receptors, reducing heart rate and contractility
,C. Stimulate alpha-1 receptors causing vasodilation
D. Increase peripheral resistance and cardiac output
Answer: B
Beta-blockers block beta-adrenergic receptors, leading to decreased heart rate, blood pressure, and
myocardial oxygen demand.
2. ACE inhibitors lower blood pressure by:
A. Direct vasodilation of arterioles
B. Blocking angiotensin I conversion to angiotensin II
C. Increasing norepinephrine release
D. Stimulating aldosterone secretion
Answer: B
ACE inhibitors prevent angiotensin II formation, decreasing vasoconstriction and aldosterone-
mediated sodium retention.
3. A serious side effect of ACE inhibitors is:
A. Constipation
B. Hyperkalemia
C. Tachycardia
D. Hypernatremia
Answer: B
ACE inhibitors decrease aldosterone, which can lead to potassium retention and hyperkalemia.
4. A patient on warfarin should avoid which of the following?
A. High-protein diets
B. Spinach and broccoli
C. Dairy products
D. Citrus fruits
Answer: B
Green leafy vegetables are high in vitamin K, which antagonizes warfarin's anticoagulant effect.
5. Which insulin has the fastest onset of action?
A. NPH
B. Regular
C. Glargine
D. Lispro
Answer: D
, Insulin lispro is rapid-acting, with onset in 10–15 minutes.
6. Black box warning for fluoroquinolones includes:
A. Hepatic failure
B. Tendon rupture
C. Cardiac arrhythmia
D. Nephrotoxicity
Answer: B
Fluoroquinolones (e.g., ciprofloxacin) are associated with tendonitis and tendon rupture.
7. First-line treatment for hypertension in African American adults without CKD is:
A. ACE inhibitor
B. Beta-blocker
C. Thiazide diuretic or CCB
D. ARB
Answer: C
Thiazide diuretics or calcium channel blockers are first-line per JNC-8 guidelines.
8. Metformin is contraindicated in:
A. Type 2 diabetes
B. Pregnancy
C. Renal insufficiency
D. Obesity
Answer: C
Metformin is excreted renally; accumulation increases risk for lactic acidosis.
9. Statins primarily work by:
A. Blocking fat absorption
B. Inhibiting HMG-CoA reductase
C. Increasing HDL clearance
D. Blocking cholesterol reabsorption
Answer: B
Statins inhibit the HMG-CoA reductase enzyme, which reduces cholesterol synthesis in the liver.
10. Which antihypertensive is safe in pregnancy?
