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PMHNP Clinical Psychopharmacology – Exam #3 Summary – Nurse Practitioner Program – Hallucinogens, Cannabinoids, and Substance Use Disorders

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This document is a comprehensive study guide for Exam #3 in Clinical Psychopharmacology within the PMHNP (Psychiatric-Mental Health Nurse Practitioner) program. It covers the pharmacology, mechanisms of action, and physiological effects of cannabis, synthetic cannabinoids, hallucinogens (e.g., LSD, PCP, ketamine), MDMA, opioids, alcohol, nicotine, and other substances. The guide also addresses addiction, receptor involvement (CB1, 5-HT2A, NMDA, dopamine), and key brain regions affected. It is highly useful for understanding both therapeutic use and abuse potential of psychoactive substances.

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​PMHNP Clinical Psychopharmacology – Exam #3​
​Summary – Nurse Practitioner Program – Hallucinogens,​
​Cannabinoids, and Substance Use Disorders​

​1.​ ​Tolerance to THC has been measured in terms of​
​decreases in what?​​CB1 receptor densities​

​2.​ ​What is one of the most reliable physiological effects of​
​cannabis use in humans?​​Increased hunger​

​3.​ ​The reinforcing effects of THC are dependent on and​
​involve what?​​CB1 receptors; increased dopamine release in​
​the nucleus accumbens​

​4.​ ​Marijuana appears to stimulate dopamine release in the​
​nucleus accumbens via inhibition of what release and in​
​what area?​​GABA; VTA​

​5.​ ​What have synthetic designer cannabinoids been called?​
​Spice​

​6.​ ​The amount of active ingredient absorbed during​
​marijuana smoking depends on all of the following except​
​for what?​​The psychological state of the user​

​7.​ ​Which statement about the endocannabinoids is false?​

, ​They are synthesized by FAAH​

​8.​ ​What is the effect of oral administration of marijuana?​
​Leads to reduced blood levels due to first-pass metabolism and​
​breakdown of the drug in the stomach​

​9.​ ​All of the following are effects that have been correlated​
​with chronic use of marijuana except for what?​
​Development of anxiety disorders​

​10.​ ​Which drug is a CB1 antagonist?​​Rimonabant​

​11.​​Are cannabis plants used for hemp different strains than​
​those prized for their psychoactive properties?​​True​

​12.​ ​Cheech's confections is offering a new line of edible​
​marijuana treats. Although each treat has the same​
​amount of marijuana, which product won't give the desired​
​psychedelic effect?​​Cupcakes with fresh cannabis sprinkles​
​(key word is fresh)​

​13.​ ​Your two friends Summer and Rain are opening a natural​
​remedies shop and have been growing cannabis to sell​
​CBD-inspired products. Their business idea is a "U-pick"​
​where customers harvest their own cannabis leaves and​
​then extract the CBD through a distillation process that​
​heats the CBD mixture. Is this a viable idea?​​Yes​

​14.​ ​Your friend is headed to the local plant nursery to pick​
​up some cannabis plants. If they want the highest possible​
​THC levels, which should they select?​​Female plant​

​15.​ ​Which form of cannabis has the lowest THC levels?​
​Bhang​

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