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NU 641 GOUT MEDICATIONS EXAM WITH
CORRECT ANSWERS 2025
Is gout a form of arthritis? What happens in gout? - correct -answer-Yes. It is
considered a form of arthritis.
In gout, purine metabolism is altered leading to increased uric acid
Hyperuricemia
Urate Crystals deposit in joints, tendons and surrounding tissues
Usually characterized by recurrent attacks of acute inflammatory arthritis - a red,
tender, hot, swollen joint
What is the most commonly affected joint in gout? - correct -answer-The
metatarsal-phalangeal joint at the base of the big toe is the most commonly
affected (approximately 50% of cases)
Colchicine ADRs - correct -answer--Colchicine patients if have elevated plasma
levels due to renal function - may develop myopathy and neuropathy that result in
weakness
-Colchicine causes reversible vitamin B12 malabsorption
-At higher doses Colchicine causes significant diarrhea
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What is the only antigout drug that has few drug interactions? - correct -answer-
Colchicine has few drug interactions
All others have many drug interactions - make sure to check before prescribing
Allopurinol indications - correct -answer-preventive drug of choice for patient
with urinary calculi, chronic tophaceous gout or high serum urate levels
Allupurinol ADRs - correct -answer-Allopurinol - maculopapular skin rash -
increased in renal disorders
May cause hepatotoxicity
Febuxostat indication - correct -answer-Febuxostat is used for chronic gout in
patients with hyperuricemia
Febuxostat dosing. Is it titrated up or down? - correct -answer-Titrated up: Start at
40 mg/day then increase to 80 mg/day when serum uric acid is < 6 mg/mL after 2
weeks
NU 641 GOUT MEDICATIONS EXAM WITH
CORRECT ANSWERS 2025
Is gout a form of arthritis? What happens in gout? - correct -answer-Yes. It is
considered a form of arthritis.
In gout, purine metabolism is altered leading to increased uric acid
Hyperuricemia
Urate Crystals deposit in joints, tendons and surrounding tissues
Usually characterized by recurrent attacks of acute inflammatory arthritis - a red,
tender, hot, swollen joint
What is the most commonly affected joint in gout? - correct -answer-The
metatarsal-phalangeal joint at the base of the big toe is the most commonly
affected (approximately 50% of cases)
Colchicine ADRs - correct -answer--Colchicine patients if have elevated plasma
levels due to renal function - may develop myopathy and neuropathy that result in
weakness
-Colchicine causes reversible vitamin B12 malabsorption
-At higher doses Colchicine causes significant diarrhea
, 2|Page
What is the only antigout drug that has few drug interactions? - correct -answer-
Colchicine has few drug interactions
All others have many drug interactions - make sure to check before prescribing
Allopurinol indications - correct -answer-preventive drug of choice for patient
with urinary calculi, chronic tophaceous gout or high serum urate levels
Allupurinol ADRs - correct -answer-Allopurinol - maculopapular skin rash -
increased in renal disorders
May cause hepatotoxicity
Febuxostat indication - correct -answer-Febuxostat is used for chronic gout in
patients with hyperuricemia
Febuxostat dosing. Is it titrated up or down? - correct -answer-Titrated up: Start at
40 mg/day then increase to 80 mg/day when serum uric acid is < 6 mg/mL after 2
weeks
