43-44_NSAIDs
Study online at https://quizlet.com/_ch6hu0
1. Which of the following drugs is an NSAID is highly Firocoxib
selective COX-2 inhibitor developed specifically for an-
imals and used to treat the pain and inflammation
associated with osteoarthritis but also transitional cell
carcinoma?
a. Piroxicam
b. Carprofen
c. Firocoxib
d. Ketoprofen
2. Which of the following is an incorrect statement about Concurrent use of a glu-
the drug interactions of an NSAID? cocorticosteroid is encour-
aged, since this practice
a. Concurrent use of diazepam may increase the activ- will ensure better anti-in-
ity of both drugs flammatory effects
b. Concurrent use of a glucocorticosteroid is encour-
aged, since this practice will ensure better anti-inflam-
matory effects
c. Concurrent use of gentamycin can increase the
nephrotoxicity of the NSAID
d. Concurrent use of 2 NSAIDs should be avoided
3. Which of the following statements does not accurately Increased bleeding times
represent the consequences of NSAID utilization? may result from the use of
a COX-1 selective inhibitor
a. Chronic use of NSAIDs can decrease renal blood flow due mainly to its inhibition
and thus, can decrease renal filtration of PGF2alpha
b. Chronic use of a COX-1 selective inhibitor can pro-
mote gastric ulcer formation
c. Increased bleeding times may result from the use of
a COX-1 selective inhibitor due mainly to its inhibition
, 43-44_NSAIDs
Study online at https://quizlet.com/_ch6hu0
of PGF2alpha
d. Increased risk of thrombosis could potentially occur
following chronic use of COX-2 inhibitors, due to its
inhibition of PGI2 synthesis by the endothelium
4. Which of the following is generally true regarding the They typically undergo en-
pharmacokinetics of NSAIDS? terohepatic recycling, and
the amount of recycling
a. They are absorbed mainly in the stomach and intes- exhibited by a given NSAID
tine, but their absorption into inflamed tissue can be can determine its half life
problematic
b. They are highly protein bound, so drug-drug inter-
actions are rare
c. They typically undergo enterohepatic recycling, and
the amount of recycling exhibited by a given NSAID can
determine its half life
d. They have a large Vd
5. Which one of the following is an incorrect statement The binding pocket of
regarding COX-2? COX-2 is small compared
to that of COX-1
a. Aspirin irreversibly inhibits this enzyme
b. COX-2 inhibitors are structurally larger than COX-1
selective inhibitors
c. The binding pocket of COX-2 is small compared to
that of COX-1
d. COX-2 is an inducible enzyme but is constitutively ex-
pressed in brain, kidney, and vascular smooth muscle
6. With respect to their COX-2 selectivity, which one is Phenylbutazone < Meloxi-
correctly ordered? cam < Firocoxib
a. Meloxicam < Ketoprofen < Carprofen
Study online at https://quizlet.com/_ch6hu0
1. Which of the following drugs is an NSAID is highly Firocoxib
selective COX-2 inhibitor developed specifically for an-
imals and used to treat the pain and inflammation
associated with osteoarthritis but also transitional cell
carcinoma?
a. Piroxicam
b. Carprofen
c. Firocoxib
d. Ketoprofen
2. Which of the following is an incorrect statement about Concurrent use of a glu-
the drug interactions of an NSAID? cocorticosteroid is encour-
aged, since this practice
a. Concurrent use of diazepam may increase the activ- will ensure better anti-in-
ity of both drugs flammatory effects
b. Concurrent use of a glucocorticosteroid is encour-
aged, since this practice will ensure better anti-inflam-
matory effects
c. Concurrent use of gentamycin can increase the
nephrotoxicity of the NSAID
d. Concurrent use of 2 NSAIDs should be avoided
3. Which of the following statements does not accurately Increased bleeding times
represent the consequences of NSAID utilization? may result from the use of
a COX-1 selective inhibitor
a. Chronic use of NSAIDs can decrease renal blood flow due mainly to its inhibition
and thus, can decrease renal filtration of PGF2alpha
b. Chronic use of a COX-1 selective inhibitor can pro-
mote gastric ulcer formation
c. Increased bleeding times may result from the use of
a COX-1 selective inhibitor due mainly to its inhibition
, 43-44_NSAIDs
Study online at https://quizlet.com/_ch6hu0
of PGF2alpha
d. Increased risk of thrombosis could potentially occur
following chronic use of COX-2 inhibitors, due to its
inhibition of PGI2 synthesis by the endothelium
4. Which of the following is generally true regarding the They typically undergo en-
pharmacokinetics of NSAIDS? terohepatic recycling, and
the amount of recycling
a. They are absorbed mainly in the stomach and intes- exhibited by a given NSAID
tine, but their absorption into inflamed tissue can be can determine its half life
problematic
b. They are highly protein bound, so drug-drug inter-
actions are rare
c. They typically undergo enterohepatic recycling, and
the amount of recycling exhibited by a given NSAID can
determine its half life
d. They have a large Vd
5. Which one of the following is an incorrect statement The binding pocket of
regarding COX-2? COX-2 is small compared
to that of COX-1
a. Aspirin irreversibly inhibits this enzyme
b. COX-2 inhibitors are structurally larger than COX-1
selective inhibitors
c. The binding pocket of COX-2 is small compared to
that of COX-1
d. COX-2 is an inducible enzyme but is constitutively ex-
pressed in brain, kidney, and vascular smooth muscle
6. With respect to their COX-2 selectivity, which one is Phenylbutazone < Meloxi-
correctly ordered? cam < Firocoxib
a. Meloxicam < Ketoprofen < Carprofen
