NU 641 GOUT LATEST
MEDICATIONS
What is the difference between Sulfinpyrazone and Probenecid ? -
ANSWERS-Sulfinpyrazone
Also competitively inhibits platelet prostaglandin synthesis gives drug
antithrombotic effect (antiplatelet)
What is the only antigout medication that does not require renal dose
adjustment? - ANSWERS-Febuxostat.
All other do require
What is the only antigout medication rated pregnancy category B? -
ANSWERS-Probenecid
Allopurinol, colchicine and febuxostat are Pregnancy Category C
Sulfinpyrazone is Pregnancy Category D
What are two antigout medications that are sulfa-based and should be
used with caution in sulfa allergies? - ANSWERS-Probenecid and
sulfinpyrazone are sulfa-based drugs - be careful in sulfa Allergy
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, NU 641 GOUT LATEST
MEDICATIONS
What are the three antigout medications that cause GI ADRs and should
be used cautiously in patients with PUD or spastic colon? - ANSWERS-
Colchicine, probenecid, and sulfinpyrazone.
Colchicine causes significant diarrhea
What are two antigout medications that may cause hepatoxicity ? -
ANSWERS-Allopurinol and colchicine may cause hepatoxicity
Clinical use of Colchicine - ANSWERS-Acute gout attacks
Low dose: 1.2 mg at the first sign of flare, followed in 1 hour with a
single dose of 0.6 mg (maximum: 1.8 mg within 1 hour).
Wait 12 hours before resuming prophylaxis dose.
Should you use high dose of Colchicine to treat acute gout? -
ANSWERS-No. Current FDA-approved dose for gout flare is
substantially lower than what has been historically used clinically. Doses
larger than the currently recommended dosage for gout flare have not
been proven to be more effective. With higher doses pt tend to develop
diarrhea.
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PAGE
2
MEDICATIONS
What is the difference between Sulfinpyrazone and Probenecid ? -
ANSWERS-Sulfinpyrazone
Also competitively inhibits platelet prostaglandin synthesis gives drug
antithrombotic effect (antiplatelet)
What is the only antigout medication that does not require renal dose
adjustment? - ANSWERS-Febuxostat.
All other do require
What is the only antigout medication rated pregnancy category B? -
ANSWERS-Probenecid
Allopurinol, colchicine and febuxostat are Pregnancy Category C
Sulfinpyrazone is Pregnancy Category D
What are two antigout medications that are sulfa-based and should be
used with caution in sulfa allergies? - ANSWERS-Probenecid and
sulfinpyrazone are sulfa-based drugs - be careful in sulfa Allergy
END OF
PAGE
1
, NU 641 GOUT LATEST
MEDICATIONS
What are the three antigout medications that cause GI ADRs and should
be used cautiously in patients with PUD or spastic colon? - ANSWERS-
Colchicine, probenecid, and sulfinpyrazone.
Colchicine causes significant diarrhea
What are two antigout medications that may cause hepatoxicity ? -
ANSWERS-Allopurinol and colchicine may cause hepatoxicity
Clinical use of Colchicine - ANSWERS-Acute gout attacks
Low dose: 1.2 mg at the first sign of flare, followed in 1 hour with a
single dose of 0.6 mg (maximum: 1.8 mg within 1 hour).
Wait 12 hours before resuming prophylaxis dose.
Should you use high dose of Colchicine to treat acute gout? -
ANSWERS-No. Current FDA-approved dose for gout flare is
substantially lower than what has been historically used clinically. Doses
larger than the currently recommended dosage for gout flare have not
been proven to be more effective. With higher doses pt tend to develop
diarrhea.
END OF
PAGE
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