USMLE STEP 3 - DRUG MOA (INDICATIONS) EXAM 2025 QUESTIONS AND ANSWERS

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USMLE STEP 3 - DRUG MOA (INDICATIONS) EXAM 2025 QUESTIONS AND ANSWERS

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Institution PHARMACOLOGY NBME

Course PHARMACOLOGY NBME

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USMLE STEP 3 - DRUG MOA (INDICATIONS) EXAM 2025 QUESTIONS AND ANSWERS

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USMLE STEP 3 - DRUG MOA
(INDICATIONS) EXAM 2025
QUESTIONS AND ANSWERS

Erythromycin - ....ANSWER ...-50S ribosome, inhibits

TRANSLOCATION (movement of tRNA-aa from acceptor site to peptidyl site)

clindamycin, chloramphenicol - ....ANSWER ...-50 ribosome, inhibits

PEPTIDYL TRANSFERASE (incorporation of new a.a.'s into growing strand)

linezolid - ....ANSWER ...-50S protein synthesis inhibitor

tetracycline - ....ANSWER ...-30S ribosome, blocks tRNA-aa from binding

to ACCEPTOR SITE on mRNA

aminoglycosides - ....ANSWER ...-30S ribosome, blocks INITIATION of

translation and induces PREMATURE TERMINATION or mistranslation

vancomycin - ....ANSWER ...-binds D-ala-D-ala portion of cell wall

precursors, prevents POLYMERIZATION OF PEPTIDOGLYCANS

....COPYRIGHT ©️ 2025 ALL RIGHTS RESERVED...TRUSTED & VERIFIED 1

, cephalosporins - ....ANSWER ...-beta-lactam, with with some resistance to

penicillinase

ampicillin, amoxicillin - ....ANSWER ...-beta-lactam, broader spectrum but

still susceptible to penicillinase

ticarcillin, piperacillin - ....ANSWER ...-beta-lactam, broad-spectrum

rifampin - ....ANSWER ...-blocks mRNA transcription by inhibiting mRNA

POLYMERASE beta subunit

metronidazole - ....ANSWER ...-interacts with microbial ferredoxins to

produce CYTOTOXIC INTERMEDIATES

fluoroquinolones - ....ANSWER ...-inhibits DNA GYRASE (controls

supercoiling) and TOPOISOMERASE (untangling interlocked daughter

chromosomes)

trimethroprim - ....ANSWER ...-inhibits DIHYDROFOLATE

REDUCTASE --> decreased syntesis of thymidylate, purine nucleotides, amino

acids

penicillin (beta-lactam) - ....ANSWER ...-1) bind PBPs

2) block TRANSPEPTIDASE cross-linking of peptidoglycan

3) activate AUTOLYTIC ENZYMES

....COPYRIGHT ©️ 2025 ALL RIGHTS RESERVED...TRUSTED & VERIFIED 2

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