USA NU578 Exam 3
What is the moa for diuretics? - answer Affects Maintenance of ecf volume and
composition
What is the Path that urine takes through the nephron - answer Glomerulus▶️Prox
convol tube▶️Loop of Henle: Descending limb▶️Ascending limb▶️DCT▶️Collecting duct
What is the site of action for osmotic diuretics like
Mannitol? - answer Proximal convoluted tubule
What is the Site of action for Thiazide diuretics like
HCTZ? - answer Early distal convoluted tubule
What is the (site of action for Potassium sparing diuretics like
Spironolactone? - answerLate distal convoluted tubule and collecting duct (distal
nephron)
What is the sote of action for Loop diuretics like
Furosemide? - answer Loop of Henle
Loop diuretics cause drug toxicity due to increased Na+ excretion. - answer Lithium
excretion is decreased with hyponatremia and causes lithium toxicity.
Nephron order of diuretic action - answerOsmotics▶️Loops
▶️Thiazides▶️K+ sparing
PCT (proximal convoluted tubule) - answerHigh resorptive capacity. About 65% of
filtered Na+ and Cl resorbed here. Urine is isotonic
Freely permeable to water - answerDescending limb loop of Henle
Na/K exchange: Na+ reabsorbed, K+ excreted stimulated by - answerDistal nephron:
late DCT/CD
Causes transient deafness - answerFurosemide
Only diuretic class that is ototoxic - answerLoop diuretics (pg451)
Digoxin is potentiated with hypokalemia and ventricular dysrhythmias are greatly
increased. These diuretics promote K+ loss. - answerLoop diuretics
Thiazide diuretics
, Preferred drugs for mobilizing edema associated with mild to moderate 💕 failure -
answerThiazides
Diuretic Must be given parenterally. Only osmotic avail in US - answerMannitol
Diuretic Works on distal nephron to block Na+ and K+ Exchange - answerMidamor
Hypokalemia is a special problem for patients taking ________ - answerDigoxin
p.456
Aldactone - answerBlocks aldosterone in distal nephron therefore there is LESS
potassium excreted and more sodium
First line drugs for hypertension - answerThiazides
Reduction of blood volume and reduction of arterial resistance (MOA) - answerThiazide
diuretics
Principle adverse effect is hypokalemia - answerThiazides
Produce much greater diuresis than thiazides - answerLoop diuretics
Diuretics not used routinely for HTN - answerLoop diuretics
Diuretics used for low GFR and patients needing ⬆️diuresis - answerLoop diuretics
Their most significant adverse effect is hyperkalemia - answerPotassium sparing
diuretics
Cannot be used with ACEIs, ARBs, or aldosterone agonists because these agents
promote hyperkalemia - answerPotassium sparing diuretics
Used to treat HTn and edema associated with 💗 failure - answerLoop diuretics and
thiazides
p.456
These hypertensive meds can cause REFLEX TACHYCARDIA, dizziness, gingival
hyperplasia, peripheral edema - answerCCBs
Dihydropyridines
p. 508
These hypertensive meds block glocogenolysis and mask early signs of hypoglycemia. -
answerBeta blockers
p. 511
What is the moa for diuretics? - answer Affects Maintenance of ecf volume and
composition
What is the Path that urine takes through the nephron - answer Glomerulus▶️Prox
convol tube▶️Loop of Henle: Descending limb▶️Ascending limb▶️DCT▶️Collecting duct
What is the site of action for osmotic diuretics like
Mannitol? - answer Proximal convoluted tubule
What is the Site of action for Thiazide diuretics like
HCTZ? - answer Early distal convoluted tubule
What is the (site of action for Potassium sparing diuretics like
Spironolactone? - answerLate distal convoluted tubule and collecting duct (distal
nephron)
What is the sote of action for Loop diuretics like
Furosemide? - answer Loop of Henle
Loop diuretics cause drug toxicity due to increased Na+ excretion. - answer Lithium
excretion is decreased with hyponatremia and causes lithium toxicity.
Nephron order of diuretic action - answerOsmotics▶️Loops
▶️Thiazides▶️K+ sparing
PCT (proximal convoluted tubule) - answerHigh resorptive capacity. About 65% of
filtered Na+ and Cl resorbed here. Urine is isotonic
Freely permeable to water - answerDescending limb loop of Henle
Na/K exchange: Na+ reabsorbed, K+ excreted stimulated by - answerDistal nephron:
late DCT/CD
Causes transient deafness - answerFurosemide
Only diuretic class that is ototoxic - answerLoop diuretics (pg451)
Digoxin is potentiated with hypokalemia and ventricular dysrhythmias are greatly
increased. These diuretics promote K+ loss. - answerLoop diuretics
Thiazide diuretics
, Preferred drugs for mobilizing edema associated with mild to moderate 💕 failure -
answerThiazides
Diuretic Must be given parenterally. Only osmotic avail in US - answerMannitol
Diuretic Works on distal nephron to block Na+ and K+ Exchange - answerMidamor
Hypokalemia is a special problem for patients taking ________ - answerDigoxin
p.456
Aldactone - answerBlocks aldosterone in distal nephron therefore there is LESS
potassium excreted and more sodium
First line drugs for hypertension - answerThiazides
Reduction of blood volume and reduction of arterial resistance (MOA) - answerThiazide
diuretics
Principle adverse effect is hypokalemia - answerThiazides
Produce much greater diuresis than thiazides - answerLoop diuretics
Diuretics not used routinely for HTN - answerLoop diuretics
Diuretics used for low GFR and patients needing ⬆️diuresis - answerLoop diuretics
Their most significant adverse effect is hyperkalemia - answerPotassium sparing
diuretics
Cannot be used with ACEIs, ARBs, or aldosterone agonists because these agents
promote hyperkalemia - answerPotassium sparing diuretics
Used to treat HTn and edema associated with 💗 failure - answerLoop diuretics and
thiazides
p.456
These hypertensive meds can cause REFLEX TACHYCARDIA, dizziness, gingival
hyperplasia, peripheral edema - answerCCBs
Dihydropyridines
p. 508
These hypertensive meds block glocogenolysis and mask early signs of hypoglycemia. -
answerBeta blockers
p. 511
