1
ATI Pharmacology Proctored
2025 Practice – 70 Questions
with Verified Answers | 100%
Correct | A+ Grade
Drug Classifications and Pharmacodynamics (15 Questions)
Question 1 (Multiple-Choice)
What is the primary action of metformin in treating type 2 diabetes?
A) Stimulates insulin release
B) Decreases hepatic glucose production
C) Increases glucagon secretion
D) Enhances glucose excretion in urine
Rationale: Metformin reduces hepatic glucose output and improves insulin sensitivity, a key
mechanism in type 2 diabetes management, per ATI guidelines.
Question 2 (Multiple-Choice)
Which medication is classified as a loop diuretic?
A) Spironolactone
B) Furosemide
C) Hydrochlorothiazide
D) Mannitol
Rationale: Furosemide inhibits sodium and chloride reabsorption in the loop of Henle,
characteristic of loop diuretics, per ATI curriculum.
Question 3 (Multiple-Choice)
What is the mechanism of action of beta-blockers like metoprolol?
A) Vasodilation of blood vessels
B) Blockade of beta-adrenergic receptors
C) Inhibition of sodium-potassium ATPase
D) Stimulation of angiotensin II receptors
, 2
Rationale: Beta-blockers reduce heart rate and contractility by blocking beta-adrenergic
receptors, per ATI pharmacodynamics.
Question 4 (NGN: Select-All-That-Apply)
Which of the following are effects of opioid analgesics? Select all that apply:
A) Pain relief
B) Respiratory depression
C) Increased blood pressure
D) Constipation
E) Hyperglycemia
Correct Answers: A, B, D
Rationale: Opioids relieve pain, depress respiration, and cause constipation by acting on mu
receptors. They do not typically affect blood pressure or glucose, per ATI guidelines.
Question 5 (Multiple-Choice)
Which class of antibiotics inhibits bacterial cell wall synthesis?
A) Macrolides
B) Penicillins
C) Fluoroquinolones
D) Tetracyclines
Rationale: Penicillins, like amoxicillin, disrupt cell wall synthesis, leading to bacterial lysis, per
ATI drug classification.
Question 6 (Multiple-Choice)
What is the primary action of selective serotonin reuptake inhibitors (SSRIs)?
A) Block dopamine receptors
B) Increase serotonin levels in synapses
C) Inhibit GABA reuptake
D) Stimulate norepinephrine release
Rationale: SSRIs, like sertraline, increase serotonin by inhibiting its reuptake, per ATI
pharmacodynamics.
Question 7 (Multiple-Choice)
Which medication is an example of an ACE inhibitor?
A) Lisinopril
B) Losartan
C) Amlodipine
D) Metoprolol
Rationale: Lisinopril inhibits angiotensin-converting enzyme, reducing blood pressure, per ATI
curriculum.
Question 8 (Short-Answer)
, 3
What is the primary therapeutic use of bronchodilators like albuterol?
Answer: Albuterol relaxes bronchial smooth muscles to relieve bronchospasm in asthma or
COPD.
Rationale: Bronchodilators are beta-2 agonists that open airways, per ATI guidelines.
Question 9 (Multiple-Choice)
What is the action of antihistamines like diphenhydramine?
A) Stimulate histamine release
B) Block histamine H1 receptors
C) Inhibit serotonin reuptake
D) Increase acetylcholine levels
Rationale: Diphenhydramine blocks H1 receptors, reducing allergic symptoms, per ATI
pharmacodynamics.
Question 10 (Multiple-Choice)
Which medication is a calcium channel blocker?
A) Amlodipine
B) Enalapril
C) Propranolol
D) Spironolactone
Rationale: Amlodipine blocks calcium entry into vascular smooth muscle, causing vasodilation,
per ATI drug classification.
Question 11 (NGN: Fill-in-the-Blank)
A nurse is teaching a client about warfarin. The nurse should monitor the client’s ________ to
assess therapeutic effect.
Answer: INR
Rationale: International Normalized Ratio (INR) monitors warfarin’s anticoagulant effect,
targeting 2-3 for most conditions, per ATI guidelines.
Question 12 (Multiple-Choice)
What is the primary action of statins like atorvastatin?
A) Increase HDL cholesterol
B) Inhibit HMG-CoA reductase
C) Block beta receptors
D) Enhance triglyceride synthesis
Rationale: Statins reduce cholesterol synthesis by inhibiting HMG-CoA reductase, per ATI
pharmacodynamics.
Question 13 (Multiple-Choice)
ATI Pharmacology Proctored
2025 Practice – 70 Questions
with Verified Answers | 100%
Correct | A+ Grade
Drug Classifications and Pharmacodynamics (15 Questions)
Question 1 (Multiple-Choice)
What is the primary action of metformin in treating type 2 diabetes?
A) Stimulates insulin release
B) Decreases hepatic glucose production
C) Increases glucagon secretion
D) Enhances glucose excretion in urine
Rationale: Metformin reduces hepatic glucose output and improves insulin sensitivity, a key
mechanism in type 2 diabetes management, per ATI guidelines.
Question 2 (Multiple-Choice)
Which medication is classified as a loop diuretic?
A) Spironolactone
B) Furosemide
C) Hydrochlorothiazide
D) Mannitol
Rationale: Furosemide inhibits sodium and chloride reabsorption in the loop of Henle,
characteristic of loop diuretics, per ATI curriculum.
Question 3 (Multiple-Choice)
What is the mechanism of action of beta-blockers like metoprolol?
A) Vasodilation of blood vessels
B) Blockade of beta-adrenergic receptors
C) Inhibition of sodium-potassium ATPase
D) Stimulation of angiotensin II receptors
, 2
Rationale: Beta-blockers reduce heart rate and contractility by blocking beta-adrenergic
receptors, per ATI pharmacodynamics.
Question 4 (NGN: Select-All-That-Apply)
Which of the following are effects of opioid analgesics? Select all that apply:
A) Pain relief
B) Respiratory depression
C) Increased blood pressure
D) Constipation
E) Hyperglycemia
Correct Answers: A, B, D
Rationale: Opioids relieve pain, depress respiration, and cause constipation by acting on mu
receptors. They do not typically affect blood pressure or glucose, per ATI guidelines.
Question 5 (Multiple-Choice)
Which class of antibiotics inhibits bacterial cell wall synthesis?
A) Macrolides
B) Penicillins
C) Fluoroquinolones
D) Tetracyclines
Rationale: Penicillins, like amoxicillin, disrupt cell wall synthesis, leading to bacterial lysis, per
ATI drug classification.
Question 6 (Multiple-Choice)
What is the primary action of selective serotonin reuptake inhibitors (SSRIs)?
A) Block dopamine receptors
B) Increase serotonin levels in synapses
C) Inhibit GABA reuptake
D) Stimulate norepinephrine release
Rationale: SSRIs, like sertraline, increase serotonin by inhibiting its reuptake, per ATI
pharmacodynamics.
Question 7 (Multiple-Choice)
Which medication is an example of an ACE inhibitor?
A) Lisinopril
B) Losartan
C) Amlodipine
D) Metoprolol
Rationale: Lisinopril inhibits angiotensin-converting enzyme, reducing blood pressure, per ATI
curriculum.
Question 8 (Short-Answer)
, 3
What is the primary therapeutic use of bronchodilators like albuterol?
Answer: Albuterol relaxes bronchial smooth muscles to relieve bronchospasm in asthma or
COPD.
Rationale: Bronchodilators are beta-2 agonists that open airways, per ATI guidelines.
Question 9 (Multiple-Choice)
What is the action of antihistamines like diphenhydramine?
A) Stimulate histamine release
B) Block histamine H1 receptors
C) Inhibit serotonin reuptake
D) Increase acetylcholine levels
Rationale: Diphenhydramine blocks H1 receptors, reducing allergic symptoms, per ATI
pharmacodynamics.
Question 10 (Multiple-Choice)
Which medication is a calcium channel blocker?
A) Amlodipine
B) Enalapril
C) Propranolol
D) Spironolactone
Rationale: Amlodipine blocks calcium entry into vascular smooth muscle, causing vasodilation,
per ATI drug classification.
Question 11 (NGN: Fill-in-the-Blank)
A nurse is teaching a client about warfarin. The nurse should monitor the client’s ________ to
assess therapeutic effect.
Answer: INR
Rationale: International Normalized Ratio (INR) monitors warfarin’s anticoagulant effect,
targeting 2-3 for most conditions, per ATI guidelines.
Question 12 (Multiple-Choice)
What is the primary action of statins like atorvastatin?
A) Increase HDL cholesterol
B) Inhibit HMG-CoA reductase
C) Block beta receptors
D) Enhance triglyceride synthesis
Rationale: Statins reduce cholesterol synthesis by inhibiting HMG-CoA reductase, per ATI
pharmacodynamics.
Question 13 (Multiple-Choice)
