BIO351 Module 4 Exam with |! |! |! |! |!
verified detailed solutions |! |!
Mesodermal cells at the site of the limb buds respond to beads soaked in
|! |! |! |! |! |! |! |! |! |! |! |! |! |!
FGF8 and grow out along the proximal-distal axis. If beads expressing FGF8
|! |! |! |! |! |! |! |! |! |! |! |!
are placed under the epithelium of the back there is no outgrowth. This
|! |! |! |! |! |! |! |! |! |! |! |! |!
experiment demonstrates which of the following?
|! |! |! |! |!
- Permissive induction
|! |!
- Proliferation
|!
- Competence
|!
- Gastrulation
|!
- Differentiation - Correct answer ✔- Competence
|! |! |! |! |! |!
LEC 1.3 Slide 6
|! |! |!
"Competence: a cell's ability to respond to an inductive signal."
|! |! |! |! |! |! |! |! |!
Think about this: the soaked Fgf8 beads are transplanted 'under the
|! |! |! |! |! |! |! |! |! |! |!
epithelium of the BACK ... [and] there is NO outgrowth."
|! |! |! |! |! |! |! |! |!
Because there is no outgrowth when this is translated, this means the cells of
|! |! |! |! |! |! |! |! |! |! |! |! |! |!
the back are not competent. Meaning, their signals are there/present from
|! |! |! |! |! |! |! |! |! |! |!
,Fgf8, however, the cell's (of the back) ability to comprehend and exact the
|! |! |! |! |! |! |! |! |! |! |! |! |!
goals of the Fgf8 signal is inadequate or incompetent.
|! |! |! |! |! |! |! |! |!
textbook:
Cells of the responding tissue must have both a receptor protein for the
|! |! |! |! |! |! |! |! |! |! |! |! |!
inducing factor and the ability to respond to the signal. The ability to receive
|! |! |! |! |! |! |! |! |! |! |! |! |! |!
and respond to a specific inductive signal is called competence (Waddington
|! |! |! |! |! |! |! |! |! |! |!
1940).
Researchers were examining the role of SHH on patterning the digits in the
|! |! |! |! |! |! |! |! |! |! |! |! |!
limb bud. They predict a gradient of SHH along the rostral/caudal axis is
|! |! |! |! |! |! |! |! |! |! |! |! |!
required to pattern the digits (left panel). Ablation of the Zone of Polarizing
|! |! |! |! |! |! |! |! |! |! |! |! |!
Activity (ZPA) lead to the SHH concentrations in the right panel. Based on
|! |! |! |! |! |! |! |! |! |! |! |! |!
this model, which pattern of digits (A-E) is expected.
|! |! |! |! |! |! |! |!
-C
|!
-D
|!
-E
|!
-A
|!
- B - Correct answer ✔- D
|! |! |! |! |! |!
LEC 1.3 Slides 14, 17-18
|! |! |! |!
As can be seen in the 'real' image (not depicted here), there are 2 thresholds
|! |! |! |! |! |! |! |! |! |! |! |! |! |! |!
for red, white, and blue for particular digits.
|! |! |! |! |! |! |!
, The gradient depicted is a straight, horizontal line quite low on the
|! |! |! |! |! |! |! |! |! |! |! |!
morphogen gradient. Because of this, red is the only color to be expressed.
|! |! |! |! |! |! |! |! |! |! |! |!
Somites are derived from which of the following embryonic tissues?
|! |! |! |! |! |! |! |! |!
- Endoderm
|!
- Presomitic mesoderm
|! |!
- Lateral plate mesoderm
|! |! |!
- Ectoderm - Correct answer ✔- Presomitic mesoderm
|! |! |! |! |! |! |!
LEC 1.4 Slide 14
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"Presomitic mesoderm generates somites-anlagen of the musculoskeletal
|! |! |! |! |! |! |!
system..."
LEC 4.2 Slide 5|! |! |!
"Somites segment from presomitic mesoderm."
|! |! |! |!
textbook:
When a somite is first separated from the presomitic mesoderm, all its cells
|! |! |! |! |! |! |! |! |! |! |! |! |!
are capable of becoming any of the somite-derived structures. As the somite
|! |! |! |! |! |! |! |! |! |! |! |!
verified detailed solutions |! |!
Mesodermal cells at the site of the limb buds respond to beads soaked in
|! |! |! |! |! |! |! |! |! |! |! |! |! |!
FGF8 and grow out along the proximal-distal axis. If beads expressing FGF8
|! |! |! |! |! |! |! |! |! |! |! |!
are placed under the epithelium of the back there is no outgrowth. This
|! |! |! |! |! |! |! |! |! |! |! |! |!
experiment demonstrates which of the following?
|! |! |! |! |!
- Permissive induction
|! |!
- Proliferation
|!
- Competence
|!
- Gastrulation
|!
- Differentiation - Correct answer ✔- Competence
|! |! |! |! |! |!
LEC 1.3 Slide 6
|! |! |!
"Competence: a cell's ability to respond to an inductive signal."
|! |! |! |! |! |! |! |! |!
Think about this: the soaked Fgf8 beads are transplanted 'under the
|! |! |! |! |! |! |! |! |! |! |!
epithelium of the BACK ... [and] there is NO outgrowth."
|! |! |! |! |! |! |! |! |!
Because there is no outgrowth when this is translated, this means the cells of
|! |! |! |! |! |! |! |! |! |! |! |! |! |!
the back are not competent. Meaning, their signals are there/present from
|! |! |! |! |! |! |! |! |! |! |!
,Fgf8, however, the cell's (of the back) ability to comprehend and exact the
|! |! |! |! |! |! |! |! |! |! |! |! |!
goals of the Fgf8 signal is inadequate or incompetent.
|! |! |! |! |! |! |! |! |!
textbook:
Cells of the responding tissue must have both a receptor protein for the
|! |! |! |! |! |! |! |! |! |! |! |! |!
inducing factor and the ability to respond to the signal. The ability to receive
|! |! |! |! |! |! |! |! |! |! |! |! |! |!
and respond to a specific inductive signal is called competence (Waddington
|! |! |! |! |! |! |! |! |! |! |!
1940).
Researchers were examining the role of SHH on patterning the digits in the
|! |! |! |! |! |! |! |! |! |! |! |! |!
limb bud. They predict a gradient of SHH along the rostral/caudal axis is
|! |! |! |! |! |! |! |! |! |! |! |! |!
required to pattern the digits (left panel). Ablation of the Zone of Polarizing
|! |! |! |! |! |! |! |! |! |! |! |! |!
Activity (ZPA) lead to the SHH concentrations in the right panel. Based on
|! |! |! |! |! |! |! |! |! |! |! |! |!
this model, which pattern of digits (A-E) is expected.
|! |! |! |! |! |! |! |!
-C
|!
-D
|!
-E
|!
-A
|!
- B - Correct answer ✔- D
|! |! |! |! |! |!
LEC 1.3 Slides 14, 17-18
|! |! |! |!
As can be seen in the 'real' image (not depicted here), there are 2 thresholds
|! |! |! |! |! |! |! |! |! |! |! |! |! |! |!
for red, white, and blue for particular digits.
|! |! |! |! |! |! |!
, The gradient depicted is a straight, horizontal line quite low on the
|! |! |! |! |! |! |! |! |! |! |! |!
morphogen gradient. Because of this, red is the only color to be expressed.
|! |! |! |! |! |! |! |! |! |! |! |!
Somites are derived from which of the following embryonic tissues?
|! |! |! |! |! |! |! |! |!
- Endoderm
|!
- Presomitic mesoderm
|! |!
- Lateral plate mesoderm
|! |! |!
- Ectoderm - Correct answer ✔- Presomitic mesoderm
|! |! |! |! |! |! |!
LEC 1.4 Slide 14
|! |! |!
"Presomitic mesoderm generates somites-anlagen of the musculoskeletal
|! |! |! |! |! |! |!
system..."
LEC 4.2 Slide 5|! |! |!
"Somites segment from presomitic mesoderm."
|! |! |! |!
textbook:
When a somite is first separated from the presomitic mesoderm, all its cells
|! |! |! |! |! |! |! |! |! |! |! |! |!
are capable of becoming any of the somite-derived structures. As the somite
|! |! |! |! |! |! |! |! |! |! |! |!
