NR546 WEEK 6 EXAM WITH
CORRECT ANSWERS 2025
Substance Use Disorder correct answers >> Occurs when the
recurrent use of a substance, such as alcohol or drugs, causes
clinically significant impairment, including health problems,
disability, or failure to meet responsibilities at home, work, or
school.
When does drug use typically begin? correct answers >>
Adolescence
Common Comorbidities of substance use disorder correct
answers >> Anxiety disorders
depression
bipolar disorder
psychotic illness
borderline personality disorder
antisocial personality disorder
Neurological basis: Genetic factors of SUD correct answers >>
40-60% of a client's vulnerability to substance use disorders may
be attributed to genetic factors
Vulnerability involves complex interactions between multiple
genetic factors/.
,Genetic involvement may impact an individual's experience of a
drug as pleasurable or not or how long a drug remains in the
body.
Epigenetic factors in SUD` correct answers >> influence
whether genes associated with substance use disorder are
activated
Neurological Basis: Neuroanatomy in SUD correct answers >>
Brain circuits that mediate reward, impulse control, decision
making, learning, and emotions play a role in substance use
disorder.
Mesolimbic Dopamine pathway in SUD correct answers >>
has been identified as the key pathway that mediates reward.
Connects the ventral tegmental area of the midbrain to the
ventral striatum of the basal ganglia.
The pathway begins in the ventral tegmental area (VTA) and
connects to the ventral striatum/nucleus
Neurobiological Basis: Neural Networks correct answers >>
Mesolimbic pathway is most associated with reward. Drugs and
alcohol act directly on brain receptors leading to a release of
dopamine.
As substance use increases, brain circuits adapt by reducing
sensitivity to dopamine, leading to tolerance and the need to
increase use of a substance to achieve the same high.
, Neurological Basis: Neural Signaling correct answers >>
Dopamine is responsible for regulating the brain's motivation,
pleasure, and reward center.
Dopamine is release in response to natural pleasurable activities
or situations such as achieving an accomplishment, enjoying a
good meal. or participating in an athletic activity. Addictive drugs
cause a surge of dopamine in the ventral striatum or nucleus
accumbens.
Repeated use can lead to changes in brain circuitry leading to
craving, addiction, dependence, withdrawal.
What neurotransmitter is the target when treating SUD?
correct answers >> Dopamine.
Tolerance correct answers >> With repeated ingestion of a
drug, the drug shows decreased effect. Increasing doses are
required to achieve the effects noted with the original
administration
Dependence correct answers >> State of adaption produced
with repeated administration of certain drugs so that physical
symptoms occur when the drug is discontinued abruptly.
Addiction correct answers >> A change in behavior caused
by biochemical changes in the brain after continued substance
use characterized by preoccupation with and repeated use of a
substance despite negative outcomes.
CORRECT ANSWERS 2025
Substance Use Disorder correct answers >> Occurs when the
recurrent use of a substance, such as alcohol or drugs, causes
clinically significant impairment, including health problems,
disability, or failure to meet responsibilities at home, work, or
school.
When does drug use typically begin? correct answers >>
Adolescence
Common Comorbidities of substance use disorder correct
answers >> Anxiety disorders
depression
bipolar disorder
psychotic illness
borderline personality disorder
antisocial personality disorder
Neurological basis: Genetic factors of SUD correct answers >>
40-60% of a client's vulnerability to substance use disorders may
be attributed to genetic factors
Vulnerability involves complex interactions between multiple
genetic factors/.
,Genetic involvement may impact an individual's experience of a
drug as pleasurable or not or how long a drug remains in the
body.
Epigenetic factors in SUD` correct answers >> influence
whether genes associated with substance use disorder are
activated
Neurological Basis: Neuroanatomy in SUD correct answers >>
Brain circuits that mediate reward, impulse control, decision
making, learning, and emotions play a role in substance use
disorder.
Mesolimbic Dopamine pathway in SUD correct answers >>
has been identified as the key pathway that mediates reward.
Connects the ventral tegmental area of the midbrain to the
ventral striatum of the basal ganglia.
The pathway begins in the ventral tegmental area (VTA) and
connects to the ventral striatum/nucleus
Neurobiological Basis: Neural Networks correct answers >>
Mesolimbic pathway is most associated with reward. Drugs and
alcohol act directly on brain receptors leading to a release of
dopamine.
As substance use increases, brain circuits adapt by reducing
sensitivity to dopamine, leading to tolerance and the need to
increase use of a substance to achieve the same high.
, Neurological Basis: Neural Signaling correct answers >>
Dopamine is responsible for regulating the brain's motivation,
pleasure, and reward center.
Dopamine is release in response to natural pleasurable activities
or situations such as achieving an accomplishment, enjoying a
good meal. or participating in an athletic activity. Addictive drugs
cause a surge of dopamine in the ventral striatum or nucleus
accumbens.
Repeated use can lead to changes in brain circuitry leading to
craving, addiction, dependence, withdrawal.
What neurotransmitter is the target when treating SUD?
correct answers >> Dopamine.
Tolerance correct answers >> With repeated ingestion of a
drug, the drug shows decreased effect. Increasing doses are
required to achieve the effects noted with the original
administration
Dependence correct answers >> State of adaption produced
with repeated administration of certain drugs so that physical
symptoms occur when the drug is discontinued abruptly.
Addiction correct answers >> A change in behavior caused
by biochemical changes in the brain after continued substance
use characterized by preoccupation with and repeated use of a
substance despite negative outcomes.
