NR546-FINAL EXAM-PEARLS WITH
CORRECT ANSWERS 2025
First line treatment for depression correct answers >> SSRIs
Common side effect of SSRIs correct answers >> sexual
dysfunction
rapid cycling bipolar disorder correct answers >> Minimum of
4 episodes a year
Goal of antidepressant therapy correct answers >> complete
remission of symptoms
Serotonin GI effects correct answers >> Due to the fact that
90% of 5HT receptors are located in GI tract
best tolerated SSRI correct answers >> Escitalopram
(Lexapro) also has fewest CYP interactions
Lithium levels correct answers >> Can be increased by
NSAIDS and ACE inhibitors
Can be decreased by caffeine and mania
Unaffected by amiloride, furosemide, and sulindac
,Lithium purpose correct answers >> Effective treatment for
manic episodes, to prevent reoccurrence and to a lower degree is
effective in depressive episodes
Lamotrigine correct answers >> Well tolerated except for the
propensity to cause a rash
Monoamines correct answers >> dopamine, norepinephrine,
serotonin
Lamotrigine correct answers >> Is a mood stabilizer
Lithium correct answers >> Well established to prevent
suicide in clients with mood disorders
Lithium correct answers >> Has a narrow therapeutic window
and requires law draws
1st line treatment for OCD correct answers >> SSRIs are first
line. Benzodiazepines are not!!!
Primary action of hallucinogenic drugs such as LSD,mescaline,
psilocybin, and MDMA correct answers >> Agonism of 5HT2A
receptors
Hallucinogens may have additional actions at other serotonin
receptors (particularly 5HT1A and 5HT2C) and at other
neurotransmitter systems, and MDMA in particular also blocks the
serotonin transporter (SERT)
, Controls appetite correct answers >> hypothalamus serves
as the brain center that controls appetite by utilizing a complex
set of circuits and regulators. One formulation of how the
hypothalamus does this is the notion that there is a major
appetite stimulating pathway whose actions are mediated by two
peptides (neuropeptide Y and agouti-related protein)
Phentermine correct answers >> Acts like amphetamine,
blocking both the dopamine transporter (DAT) and the
norepinephrine transporter (NET) and, at high doses, the vesicular
monoamine transporter (VMAT)
Buprenorphine correct answers >> Is also approved for <18
year olds
Disulfiram caution correct answers >> Alcohol reaction may
occur within two weeks of alcohol ingestion
Methadone correct answers >> Is a full mu-receptor agonist
with a long half-life, which can prevent withdrawal symptoms for
24 hours and provide steady control of cravings throughout the
day. In addition to its opioid receptor activity, it is also an
antagonist of the N-methyl-D-aspartate (NMDA) receptor.
Hallucinogenic intoxication correct answers >> pupillary
dilation, tachycardia, sweating, palpitations, blurred vision,
tremors, incoordination
Can be perceived as a panic attack and often called a bad trip.
Can experience an acute state of confusion (delirium) where the
abuser is disoriented and agitated.
CORRECT ANSWERS 2025
First line treatment for depression correct answers >> SSRIs
Common side effect of SSRIs correct answers >> sexual
dysfunction
rapid cycling bipolar disorder correct answers >> Minimum of
4 episodes a year
Goal of antidepressant therapy correct answers >> complete
remission of symptoms
Serotonin GI effects correct answers >> Due to the fact that
90% of 5HT receptors are located in GI tract
best tolerated SSRI correct answers >> Escitalopram
(Lexapro) also has fewest CYP interactions
Lithium levels correct answers >> Can be increased by
NSAIDS and ACE inhibitors
Can be decreased by caffeine and mania
Unaffected by amiloride, furosemide, and sulindac
,Lithium purpose correct answers >> Effective treatment for
manic episodes, to prevent reoccurrence and to a lower degree is
effective in depressive episodes
Lamotrigine correct answers >> Well tolerated except for the
propensity to cause a rash
Monoamines correct answers >> dopamine, norepinephrine,
serotonin
Lamotrigine correct answers >> Is a mood stabilizer
Lithium correct answers >> Well established to prevent
suicide in clients with mood disorders
Lithium correct answers >> Has a narrow therapeutic window
and requires law draws
1st line treatment for OCD correct answers >> SSRIs are first
line. Benzodiazepines are not!!!
Primary action of hallucinogenic drugs such as LSD,mescaline,
psilocybin, and MDMA correct answers >> Agonism of 5HT2A
receptors
Hallucinogens may have additional actions at other serotonin
receptors (particularly 5HT1A and 5HT2C) and at other
neurotransmitter systems, and MDMA in particular also blocks the
serotonin transporter (SERT)
, Controls appetite correct answers >> hypothalamus serves
as the brain center that controls appetite by utilizing a complex
set of circuits and regulators. One formulation of how the
hypothalamus does this is the notion that there is a major
appetite stimulating pathway whose actions are mediated by two
peptides (neuropeptide Y and agouti-related protein)
Phentermine correct answers >> Acts like amphetamine,
blocking both the dopamine transporter (DAT) and the
norepinephrine transporter (NET) and, at high doses, the vesicular
monoamine transporter (VMAT)
Buprenorphine correct answers >> Is also approved for <18
year olds
Disulfiram caution correct answers >> Alcohol reaction may
occur within two weeks of alcohol ingestion
Methadone correct answers >> Is a full mu-receptor agonist
with a long half-life, which can prevent withdrawal symptoms for
24 hours and provide steady control of cravings throughout the
day. In addition to its opioid receptor activity, it is also an
antagonist of the N-methyl-D-aspartate (NMDA) receptor.
Hallucinogenic intoxication correct answers >> pupillary
dilation, tachycardia, sweating, palpitations, blurred vision,
tremors, incoordination
Can be perceived as a panic attack and often called a bad trip.
Can experience an acute state of confusion (delirium) where the
abuser is disoriented and agitated.
