LATEST UPDATE / ALREADY GRADED
1. HIV EIA (3rd generation immunoassay) ANS >> can use urine, saliva, or
serum (most accurate), need to wait until 12 weeks post exposure to see antibodies,
>99% accurate
4th generation immunoassay- "gold standard"
measures P24 antigen
can test 10 days post exposure
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, NURS 5315 UTA Exam 2
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2. Mast cell ANS >> Cellular bags of granules located in loose connective
tisssue close to blood vessels. Activation initiates inflammatory process.
3. Histamine ANS >> Causes vasodilation, increases vascular permeability,
increases blood flow to the site of injury- causes erythema and swelling.
4. Cytokines ANS >> Soluble factors that contribute to the regulation of innate
or adaptive resistance by affecting other neighboring cells. Can be pro-inflammatory
or anti-inflammatory. Can react quickly or be more delayed.
5. Leukotrines ANS >> Released when mast cells degranulate, prolong the
inflammatory process. Cause vasodilation, attract neutrophils, monocytes, and
eosinophils.target of inhibition for singular.
6. Prostaglandins ANS >> Released when mast cells degranulate, are
produced by the arachidonic pathway. Cause vasodilation, platelet aggregation at
site of injury, pain, and fever.
7. Chemotactic factors ANS >> Biochemical substance that attracts leukocyte
to the site of inflammation
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, 8. Neutrophils ANS >> Predominant leukocyte at work during the early stages
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V of acute inflammation
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9. Monocytes ANS >> V V V Become macrophages when entering the tissue,
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V responsible for presenting antigens to the CD4 cell which triggers T-cell immunity
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V and B-cell immunity.
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Releases additional cytokines IL1, IL6, TNF.
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10. Cytokine IL1 function ANS >> V V V V V V Causes fever, activates phagocytes &
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V lymphocytes and also increases the release of IL6a
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11. Cytokine IL6 function ANS >> V V V V V Stimulates production of acute phase
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V reactants and promotes growth and stimulation of RBCs
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12. Cytokine TNF function ANS >> V V V V V Causes fever, increases synthesis of
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V proinflammatory proteins by liver, causes muscle wasting, induces thrombosis
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13. Cytokine growth factor function ANS >> V V V V V V Promotes production and
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V maturation of neutrophils V V
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