APHA NAPLEX (ACTUAL 2025/2026) QUESTIONS AND 100%
VERIFIED ANSWERS
Which of the following is not a potential source of physical or
chemical incompatibility?
A. dilution of a drug in a cosolvent system into an aqueous
solution
B. addition of a drug solution with a high pH into a solution
with a low pH
C. adsorption of a lipid-soluble drug into the matrix of a
polypropylene container
D. a photosensitive drug such as sodium nitroprusside is D5W
exposed to light
E. leaching of phthalate plasticizer into the solution from a PVC
container ----ANSWERS----C. Absoprtion of a lipid soluble
drug into the matrix of PVC containers does occur.
Polypropylene and polyethylene contain little or not plasticizer
Which of the following radiopharmaceuticals is indicated to
image beta-amyloid neuritic plaques in patients exhibiting
cognitive impairment?
A. Tc-99m DTPA
B. Tc-99m biscisate
C. In-111 DTPA
D. Florbetapir F-18 ----ANSWERS----D. Florbetapir F-18 is the
only one with the indication. Tc-99m DPTA is used to evaluate
patients for brain death and Tc-99m bicisate is used for
evaluation of stroke patients in the evaluation of brain death.
In-111 DTPA is indicated for cisternography studies
Which of the following radiopharmaceuticals is a controlled
substance?
,A. I-123 ioflupane
B. Florbetapir F-18
C. Thallous chloride T1-201
D. Tc-99m exametazime ----ANSWERS----A. I-123 ioflupane
is the only one is a controlled drug
Which of the following radiopharmaceuticals accumulates in
viable myocardial tissue via the Na/K ATPase pump?
A. F-18 FDG
B. Tc-99m tertrofsmin
C. Rb-82 chloride
D. Tc-99m sestamibi ----ANSWERS----C. F-18 FDG is
transported via glucose transporters, Tc-99m tetrofosmin and
Tc-99m sestamibi enter the cell via passive diffusion
Which of the following radiopharmaceuticals is a monovalent
cation and a potassium analog?
A. F-18 FDG
B. Tc-99m tetrofosmin
C. Tc-99m sestamibi
D. Thallous chloride T1-201 ----ANSWERS----D. F-18 FDG is a
glucose analog; Tc-99m tetrofosmin and Tc-99m sestamibi are
monovalent cations but not potassium analogs; thallous
chloride T1-201 is a monovalent cation and a potassium analog
Which of the following PET radiopharmaceuticals is
commercially available from a generator?
A. F-18 FDG
B. I-23 ioflupane
C. Florbetapir F-18
D. Rb-82 chloride ----ANSWERS----D. F-18 and I-123 are not
available from a generator
,Which of the following is a myocardial radiopharmaceutical
that provides information on both perfusion and left
ventricular function?
A. Rb-82 chloride
B. Tc-99m tetrofosmin
C. F-18 FDG
D. Thallous chloride T1-201 ----ANSWERS----B. F-18 FDG is an
indicator of metabolism, Rb-82 chloride and thallous chloride
provide information on myocardial perfusion. Tc-99m
tetrofosmin provides information on both myocardial perfusion
and left ventricular fn
An example of a diagnostic skeletal agent is
A. Tc-99m bicisate
B. Tc-99m MDP
C. Sr-82 chloride
D. Florbetapir F-18 ----ANSWERS----B. Tc-99m bicisate and
florbetapir F-18 are for CNS imaging. Sr 82 chloride is a
palliative therapeutic agent
What patient preparation is recommended for skeletal imaging
if the patient's condition permits?
A. bowel cleansing
B. hydration
C. thyroid blockade
D. sincalide administration ----ANSWERS----B. Hydration is
recommended.
Which of the following correctly characterizes Tc-99m HDP?
A. localizes in areas of high bone metabolic activity
B. limited to use in adult patients with metastatic lesions
C. frequent adverse reactions
, D. lipophilic cationic complex ----ANSWERS----A. Tc-99m
HDP can be used in the pediatric population, and adverse
reactions are uncommon. It is a diphosphonate complex but
not a lipophilic complex
Which of the following radiopharmaceuticals exerts it
palliative effect through its beta particle emission?
A. Tc-99m MDP
B. In-111 oxyquinoline
C. I-123 iobenguane
D. Sm-153 EDTMP ----ANSWERS----D. Sm-153 EDTMP
produces beta particles
Which of the following radiopharmaceuticals is indicated for
radiolabeling leukocytes?
A. Tc-99m DTPA
B. F-18 FDG
C. In-111 oxine
D. I-123 iobenguane ----ANSWERS----C. In-111 oxine; Tc-99m
DTPA is used in brain and renal studies, F-18 FDG is used as a
metabolic indicator, and I-123 iobenguane is used in the
detection of pheochromocytomas and neuroblastomas
An example of a radiolabeled peptide that is used in localized
primary and metastatic neuroendocrine tumors is
A. In-111 pentetreotide
B. I-123 iobenguane
C. In-111 capromab pendetide
D. I-123 ioflupane ----ANSWERS----A. I-123 benguane is used
in the detection of pheochromocytomas and neuroblastomas,
but is not a peptide, In-111 capromab is a monoclonal antibody
used in pts with prostate cancer. I-123 ioflupane is used in the
eval of pts with parkinsonian syndromes
VERIFIED ANSWERS
Which of the following is not a potential source of physical or
chemical incompatibility?
A. dilution of a drug in a cosolvent system into an aqueous
solution
B. addition of a drug solution with a high pH into a solution
with a low pH
C. adsorption of a lipid-soluble drug into the matrix of a
polypropylene container
D. a photosensitive drug such as sodium nitroprusside is D5W
exposed to light
E. leaching of phthalate plasticizer into the solution from a PVC
container ----ANSWERS----C. Absoprtion of a lipid soluble
drug into the matrix of PVC containers does occur.
Polypropylene and polyethylene contain little or not plasticizer
Which of the following radiopharmaceuticals is indicated to
image beta-amyloid neuritic plaques in patients exhibiting
cognitive impairment?
A. Tc-99m DTPA
B. Tc-99m biscisate
C. In-111 DTPA
D. Florbetapir F-18 ----ANSWERS----D. Florbetapir F-18 is the
only one with the indication. Tc-99m DPTA is used to evaluate
patients for brain death and Tc-99m bicisate is used for
evaluation of stroke patients in the evaluation of brain death.
In-111 DTPA is indicated for cisternography studies
Which of the following radiopharmaceuticals is a controlled
substance?
,A. I-123 ioflupane
B. Florbetapir F-18
C. Thallous chloride T1-201
D. Tc-99m exametazime ----ANSWERS----A. I-123 ioflupane
is the only one is a controlled drug
Which of the following radiopharmaceuticals accumulates in
viable myocardial tissue via the Na/K ATPase pump?
A. F-18 FDG
B. Tc-99m tertrofsmin
C. Rb-82 chloride
D. Tc-99m sestamibi ----ANSWERS----C. F-18 FDG is
transported via glucose transporters, Tc-99m tetrofosmin and
Tc-99m sestamibi enter the cell via passive diffusion
Which of the following radiopharmaceuticals is a monovalent
cation and a potassium analog?
A. F-18 FDG
B. Tc-99m tetrofosmin
C. Tc-99m sestamibi
D. Thallous chloride T1-201 ----ANSWERS----D. F-18 FDG is a
glucose analog; Tc-99m tetrofosmin and Tc-99m sestamibi are
monovalent cations but not potassium analogs; thallous
chloride T1-201 is a monovalent cation and a potassium analog
Which of the following PET radiopharmaceuticals is
commercially available from a generator?
A. F-18 FDG
B. I-23 ioflupane
C. Florbetapir F-18
D. Rb-82 chloride ----ANSWERS----D. F-18 and I-123 are not
available from a generator
,Which of the following is a myocardial radiopharmaceutical
that provides information on both perfusion and left
ventricular function?
A. Rb-82 chloride
B. Tc-99m tetrofosmin
C. F-18 FDG
D. Thallous chloride T1-201 ----ANSWERS----B. F-18 FDG is an
indicator of metabolism, Rb-82 chloride and thallous chloride
provide information on myocardial perfusion. Tc-99m
tetrofosmin provides information on both myocardial perfusion
and left ventricular fn
An example of a diagnostic skeletal agent is
A. Tc-99m bicisate
B. Tc-99m MDP
C. Sr-82 chloride
D. Florbetapir F-18 ----ANSWERS----B. Tc-99m bicisate and
florbetapir F-18 are for CNS imaging. Sr 82 chloride is a
palliative therapeutic agent
What patient preparation is recommended for skeletal imaging
if the patient's condition permits?
A. bowel cleansing
B. hydration
C. thyroid blockade
D. sincalide administration ----ANSWERS----B. Hydration is
recommended.
Which of the following correctly characterizes Tc-99m HDP?
A. localizes in areas of high bone metabolic activity
B. limited to use in adult patients with metastatic lesions
C. frequent adverse reactions
, D. lipophilic cationic complex ----ANSWERS----A. Tc-99m
HDP can be used in the pediatric population, and adverse
reactions are uncommon. It is a diphosphonate complex but
not a lipophilic complex
Which of the following radiopharmaceuticals exerts it
palliative effect through its beta particle emission?
A. Tc-99m MDP
B. In-111 oxyquinoline
C. I-123 iobenguane
D. Sm-153 EDTMP ----ANSWERS----D. Sm-153 EDTMP
produces beta particles
Which of the following radiopharmaceuticals is indicated for
radiolabeling leukocytes?
A. Tc-99m DTPA
B. F-18 FDG
C. In-111 oxine
D. I-123 iobenguane ----ANSWERS----C. In-111 oxine; Tc-99m
DTPA is used in brain and renal studies, F-18 FDG is used as a
metabolic indicator, and I-123 iobenguane is used in the
detection of pheochromocytomas and neuroblastomas
An example of a radiolabeled peptide that is used in localized
primary and metastatic neuroendocrine tumors is
A. In-111 pentetreotide
B. I-123 iobenguane
C. In-111 capromab pendetide
D. I-123 ioflupane ----ANSWERS----A. I-123 benguane is used
in the detection of pheochromocytomas and neuroblastomas,
but is not a peptide, In-111 capromab is a monoclonal antibody
used in pts with prostate cancer. I-123 ioflupane is used in the
eval of pts with parkinsonian syndromes
