NRS 2020: Exam #1 Review (latest update)
questions well answered
1. What is P- A transporter protein that transports many drugs out of cells -- gets rid of
Glycopro- tein? excess drugs in the body
2. What does P- Pumps drugs to bile for elimination
glyco- protein do
in the liv- er?
3. What does P-
Pumps drugs into the urine for excretion
glyco- protein do
in the kidney?
4. What does P-
glyco- Transports drugs into intestinal lumen and can reduce drug absorption
into the
protein do in the in- blood
testine?
5. What factors -Rate of dissolution
affect drug
-Surface area
absorption?
-Blood flow
-Lipid solubility
-pH partitioning
-Decreased GI motility
-Food in the gut
6. What are additive ef-When two drugs with similar actions are given together, they can
have additive
fects?
8. What are antago- nistic effects?
7. What are
synergis- tic
effects?
1/
17
,NRS 2020: Exam #1 Review (latest update)
questions well answered
ettects (1 + 1 = 2)
Occur when two drugs
administered together
interact in such a way that
their combined ettects are
greater than the sum of the
ettects for each drug given
alone (1 + 1 = greater
than 2)
-When two drugs administer
that results in a therapeutic
ettect that is less than ettect
of either drug alone
-The second drug either
diminishes or cancels the
ettect of the first drug
2/
17
, NRS 2020: Exam #1 Review (latest update)
questions well answered
9. What is drug incom- When two parenteral drugs or solutions are mixed together, the
result is
patibility? chemical deterioration of one or both of the drugs or the formation of a
physical precipitate
10. What is the -Occurs when a drug passes through the liver and goes to the
first pass duodenum and back to the liver
effect? -A large proportion of a drug is chemically changed into inactive
metabolites by the liver
-Less bioavailability of the drug
11. What is bioavailabil- The extent of drug absorption
ity?
12. What are the -Rapid onset
ad- vantages of
-Precise control over drug levels
the IV
route of administra- - Can infuse larger amounts
tion? -Able to use drugs that can be irritants to hte stomach
13. What are the -Irreversible
disad- vantages -Expensive
of the IV
route of administra- - Poorly suited for self-administration
tion? -Drug must be water-soluble
-Possible discomfort
-Risk for phlebitis or infection
14. What are the -Easy
ad-
vantages of the oral - Convenient
route of administra- - Less expensive
tion?
3/
17
questions well answered
1. What is P- A transporter protein that transports many drugs out of cells -- gets rid of
Glycopro- tein? excess drugs in the body
2. What does P- Pumps drugs to bile for elimination
glyco- protein do
in the liv- er?
3. What does P-
Pumps drugs into the urine for excretion
glyco- protein do
in the kidney?
4. What does P-
glyco- Transports drugs into intestinal lumen and can reduce drug absorption
into the
protein do in the in- blood
testine?
5. What factors -Rate of dissolution
affect drug
-Surface area
absorption?
-Blood flow
-Lipid solubility
-pH partitioning
-Decreased GI motility
-Food in the gut
6. What are additive ef-When two drugs with similar actions are given together, they can
have additive
fects?
8. What are antago- nistic effects?
7. What are
synergis- tic
effects?
1/
17
,NRS 2020: Exam #1 Review (latest update)
questions well answered
ettects (1 + 1 = 2)
Occur when two drugs
administered together
interact in such a way that
their combined ettects are
greater than the sum of the
ettects for each drug given
alone (1 + 1 = greater
than 2)
-When two drugs administer
that results in a therapeutic
ettect that is less than ettect
of either drug alone
-The second drug either
diminishes or cancels the
ettect of the first drug
2/
17
, NRS 2020: Exam #1 Review (latest update)
questions well answered
9. What is drug incom- When two parenteral drugs or solutions are mixed together, the
result is
patibility? chemical deterioration of one or both of the drugs or the formation of a
physical precipitate
10. What is the -Occurs when a drug passes through the liver and goes to the
first pass duodenum and back to the liver
effect? -A large proportion of a drug is chemically changed into inactive
metabolites by the liver
-Less bioavailability of the drug
11. What is bioavailabil- The extent of drug absorption
ity?
12. What are the -Rapid onset
ad- vantages of
-Precise control over drug levels
the IV
route of administra- - Can infuse larger amounts
tion? -Able to use drugs that can be irritants to hte stomach
13. What are the -Irreversible
disad- vantages -Expensive
of the IV
route of administra- - Poorly suited for self-administration
tion? -Drug must be water-soluble
-Possible discomfort
-Risk for phlebitis or infection
14. What are the -Easy
ad-
vantages of the oral - Convenient
route of administra- - Less expensive
tion?
3/
17
