HESI LPN Pharmacology Exit
Exam | LPN Pharmacology HESI
Prep | Latest 2025/2026 Edition |
Complete Questions with Correct
Detailed Answers | 100% Verified
Introduction
This document provides a complete and fully verified collection of questions and correct
detailed answers for the HESI LPN Pharmacology Exit Exam, newly updated for the
2025/2026 academic year. It covers critical pharmacology topics including drug classi-
fications, safe dosage calculations, adverse effects, nursing implications, and medication
administration. Each question mirrors the actual HESI exam format and includes com-
prehensive rationales to enhance learning and ensure full exam preparedness.
Exam Questions and Answers
1. A client is prescribed furosemide 40 mg daily for heart failure. Which laboratory
value should the LPN monitor closely?
A. Potassium
B. Sodium
C. Glucose
D. Calcium
Rationale: Furosemide, a loop diuretic, can cause hypokalemia due to increased potas-
sium excretion in urine, which may lead to arrhythmias. Monitoring potassium levels is
critical.
2. A client is to receive 500 mg of amoxicillin orally every 8 hours. The pharmacy
provides 250 mg capsules. How many capsules should the LPN administer per dose?
A. 2 capsules
B. 1 capsule
C. 3 capsules
D. 4 capsules
Rationale: To calculate: 500 mg ÷ 250 mg per capsule = 2 capsules per dose. This
ensures the correct dose is administered every 8 hours.
3. A client receiving warfarin reports bleeding gums. What is the LPN’s priority
action?
HESI | LPN Pharmacology Exit Exam | Verified Prep Questions | Grade A | 100%
Correct | 2025/2026
, A. Notify the healthcare provider.
B. Encourage the client to brush gently.
C. Administer vitamin C.
D. Document the finding and continue monitoring.
Rationale: Bleeding gums may indicate excessive anticoagulation from warfarin, requir-
ing immediate provider notification to assess INR and adjust therapy.
4. A client is prescribed lisinopril for hypertension. Which side effect should the LPN
teach the client to report immediately?
A. Angioedema
B. Dry cough
C. Mild fatigue
D. Headache
Rationale: Angioedema, a rare but life-threatening side effect of ACE inhibitors like
lisinopril, requires immediate medical attention due to potential airway obstruction.
5. A client is to receive heparin 5,000 units subcutaneously every 12 hours. The vial
contains 10,000 units/mL. How many mL should the LPN administer per dose?
A. 0.5 mL
B. 1 mL
C. 0.25 mL
D. 2 mL
Rationale: To calculate: 5,000 units ÷ 10,000 units/mL = 0.5 mL per dose. Accurate
calculation prevents over- or under-dosing of heparin.
6. A client with type 2 diabetes is prescribed metformin. Which instruction should
the LPN include in client teaching?
A. “Take it with meals to reduce gastrointestinal upset.”
B. “Take it on an empty stomach for better absorption.”
C. “Stop taking it if you feel better.”
D. “Expect immediate blood sugar control.”
Rationale: Metformin is best taken with meals to minimize GI side effects like nausea
and diarrhea, improving adherence.
7. A client is prescribed digoxin 0.125 mg daily. Which symptom indicates potential
digoxin toxicity?
A. Nausea and visual halos
B. Increased appetite
C. Muscle cramps
D. Dry mouth
HESI | LPN Pharmacology Exit Exam | Verified Prep Questions | Grade A | 100%
Correct | 2025/2026
, Rationale: Digoxin toxicity presents with nausea, vomiting, and visual disturbances
(e.g., yellow halos), requiring immediate reporting.
8. A client is to receive 1,000 mL of 0.9% normal saline over 8 hours. The drop factor
is 15 gtt/mL. What is the drip rate in gtt/min?
A. 31 gtt/min
B. 15 gtt/min
C. 60 gtt/min
D. 125 gtt/min
Rationale: Calculate: (1,000 mL ÷ 8 hours) × (15 gtt/mL ÷ 60 min) = 125 mL/hr ×
0.25 gtt/min/mL = 31.25 gtt/min, rounded to 31 gtt/min.
9. A client is prescribed prednisone for rheumatoid arthritis. Which adverse effect
should the LPN monitor for?
A. Weight gain
B. Hypotension
C. Hypoglycemia
D. Hair loss
Rationale: Prednisone, a corticosteroid, causes weight gain due to fluid retention and
increased appetite, requiring monitoring.
10. A client with asthma is prescribed albuterol via inhaler. What is the LPN’s priority
teaching point?
A. “Rinse your mouth after use to prevent thrush.”
B. “Use it daily to prevent asthma attacks.”
C. “Take it with food to avoid nausea.”
D. “Stop using it if you feel jittery.”
Rationale: Albuterol is a rescue inhaler, but rinsing the mouth prevents oral thrush,
especially if used with inhaled corticosteroids.
11. A client is prescribed levothyroxine for hypothyroidism. Which symptom indicates
the dose may be too high?
A. Tachycardia
B. Weight gain
C. Cold intolerance
D. Fatigue
Rationale: Excessive levothyroxine can cause hyperthyroidism symptoms like tachycar-
dia, requiring dose adjustment.
12. A client is receiving gentamicin for a bacterial infection. Which laboratory value
should the LPN monitor?
HESI | LPN Pharmacology Exit Exam | Verified Prep Questions | Grade A | 100%
Correct | 2025/2026
Exam | LPN Pharmacology HESI
Prep | Latest 2025/2026 Edition |
Complete Questions with Correct
Detailed Answers | 100% Verified
Introduction
This document provides a complete and fully verified collection of questions and correct
detailed answers for the HESI LPN Pharmacology Exit Exam, newly updated for the
2025/2026 academic year. It covers critical pharmacology topics including drug classi-
fications, safe dosage calculations, adverse effects, nursing implications, and medication
administration. Each question mirrors the actual HESI exam format and includes com-
prehensive rationales to enhance learning and ensure full exam preparedness.
Exam Questions and Answers
1. A client is prescribed furosemide 40 mg daily for heart failure. Which laboratory
value should the LPN monitor closely?
A. Potassium
B. Sodium
C. Glucose
D. Calcium
Rationale: Furosemide, a loop diuretic, can cause hypokalemia due to increased potas-
sium excretion in urine, which may lead to arrhythmias. Monitoring potassium levels is
critical.
2. A client is to receive 500 mg of amoxicillin orally every 8 hours. The pharmacy
provides 250 mg capsules. How many capsules should the LPN administer per dose?
A. 2 capsules
B. 1 capsule
C. 3 capsules
D. 4 capsules
Rationale: To calculate: 500 mg ÷ 250 mg per capsule = 2 capsules per dose. This
ensures the correct dose is administered every 8 hours.
3. A client receiving warfarin reports bleeding gums. What is the LPN’s priority
action?
HESI | LPN Pharmacology Exit Exam | Verified Prep Questions | Grade A | 100%
Correct | 2025/2026
, A. Notify the healthcare provider.
B. Encourage the client to brush gently.
C. Administer vitamin C.
D. Document the finding and continue monitoring.
Rationale: Bleeding gums may indicate excessive anticoagulation from warfarin, requir-
ing immediate provider notification to assess INR and adjust therapy.
4. A client is prescribed lisinopril for hypertension. Which side effect should the LPN
teach the client to report immediately?
A. Angioedema
B. Dry cough
C. Mild fatigue
D. Headache
Rationale: Angioedema, a rare but life-threatening side effect of ACE inhibitors like
lisinopril, requires immediate medical attention due to potential airway obstruction.
5. A client is to receive heparin 5,000 units subcutaneously every 12 hours. The vial
contains 10,000 units/mL. How many mL should the LPN administer per dose?
A. 0.5 mL
B. 1 mL
C. 0.25 mL
D. 2 mL
Rationale: To calculate: 5,000 units ÷ 10,000 units/mL = 0.5 mL per dose. Accurate
calculation prevents over- or under-dosing of heparin.
6. A client with type 2 diabetes is prescribed metformin. Which instruction should
the LPN include in client teaching?
A. “Take it with meals to reduce gastrointestinal upset.”
B. “Take it on an empty stomach for better absorption.”
C. “Stop taking it if you feel better.”
D. “Expect immediate blood sugar control.”
Rationale: Metformin is best taken with meals to minimize GI side effects like nausea
and diarrhea, improving adherence.
7. A client is prescribed digoxin 0.125 mg daily. Which symptom indicates potential
digoxin toxicity?
A. Nausea and visual halos
B. Increased appetite
C. Muscle cramps
D. Dry mouth
HESI | LPN Pharmacology Exit Exam | Verified Prep Questions | Grade A | 100%
Correct | 2025/2026
, Rationale: Digoxin toxicity presents with nausea, vomiting, and visual disturbances
(e.g., yellow halos), requiring immediate reporting.
8. A client is to receive 1,000 mL of 0.9% normal saline over 8 hours. The drop factor
is 15 gtt/mL. What is the drip rate in gtt/min?
A. 31 gtt/min
B. 15 gtt/min
C. 60 gtt/min
D. 125 gtt/min
Rationale: Calculate: (1,000 mL ÷ 8 hours) × (15 gtt/mL ÷ 60 min) = 125 mL/hr ×
0.25 gtt/min/mL = 31.25 gtt/min, rounded to 31 gtt/min.
9. A client is prescribed prednisone for rheumatoid arthritis. Which adverse effect
should the LPN monitor for?
A. Weight gain
B. Hypotension
C. Hypoglycemia
D. Hair loss
Rationale: Prednisone, a corticosteroid, causes weight gain due to fluid retention and
increased appetite, requiring monitoring.
10. A client with asthma is prescribed albuterol via inhaler. What is the LPN’s priority
teaching point?
A. “Rinse your mouth after use to prevent thrush.”
B. “Use it daily to prevent asthma attacks.”
C. “Take it with food to avoid nausea.”
D. “Stop using it if you feel jittery.”
Rationale: Albuterol is a rescue inhaler, but rinsing the mouth prevents oral thrush,
especially if used with inhaled corticosteroids.
11. A client is prescribed levothyroxine for hypothyroidism. Which symptom indicates
the dose may be too high?
A. Tachycardia
B. Weight gain
C. Cold intolerance
D. Fatigue
Rationale: Excessive levothyroxine can cause hyperthyroidism symptoms like tachycar-
dia, requiring dose adjustment.
12. A client is receiving gentamicin for a bacterial infection. Which laboratory value
should the LPN monitor?
HESI | LPN Pharmacology Exit Exam | Verified Prep Questions | Grade A | 100%
Correct | 2025/2026
