Kidney tumors questions with correct
answers
Types of benign kidney tumours ✅✅Angiomyolipoma
Oncocytoma
Type of malignant kidney tumours ✅✅Child : Wilm's tumour
Adult : RCC
What which cells does renal oncocytoma arise form ✅✅Intercalated cells of collecting
duct
Gross appearance of renal oncocytoma ✅✅Tan, mahogany brown kidney
Microscopy of renal oncocytoma ✅✅Cell with abundant eosinophilic granular
cytoplasm with ( due to abundant mitochondria)
Electron microscopy of renal oncocytoma ✅✅Excess of mitochondria
Other diseases with oncocytic cells other than renal oncocytoma ✅✅Hashimoto's
thyroiditis
Which syndrome is associated with renal angiomyolipoma ✅✅Tuberous sclerosis
Which tumours are associated with tuberous sclerosis ✅✅Renal angiomyolipoma
Cardiac rhabdomyoma
What percentage of cardiac rhabdomyomas are associated with tuberous sclerosis
✅✅50%
Spider cells are seen in the microscopy of which cardiac tumour ✅✅Rhabdomyoma
Skin lesions seen in cardiac rhabdomyoma ✅✅Shagreen patch, ash green macule
Microscopy of renal angiomyolipoma ✅✅Blood vessel, muscle, fate
Which renal malignancy occurs in childhood ✅✅Wilm's tumour
What is nephroblastoma ✅✅Wilm's tumour
Age group of Wilm's tumour ✅✅2-5 years
Presenting feature of Wilm's tumour ✅✅Abdominal mass
, What is the genetic component of Wilm's tumour ✅✅WT 1 gene on chr 11p 13
WT 2 gene on chr 11p 15
These are tumour suppressor genes which undergo loss of function mutation
Precursor lesion in Wilm's tumour ✅✅Nephrogenic cell rest
Syndromes associated with Wilm's tumour ✅✅WAGR syndrome
Deny Drash syndrome
Bechwith Weidman syndrome
Components of WAGR syndrome ✅✅Wilm's tumour
Aniridia
Genital abnormalities
mental Retardation
Which Wilm's tumour mutation is seen in Deny Drash syndrome ✅✅WT 1 gene on
chr 11p 13
What are the component of Deny Drash syndrome ✅✅Wilm's tumour
Gonadla dysgenesis
Diffuse mesangial sclerosis
Which Wilm's tumour mutation is present in Bechwith Weidman syndrome ✅✅WT 2
gene on chr 11p 15
Symptoms of Beckwith Weidman syndrome ✅✅Hemihypertrophy (organs in one half
of the body enlarge)
Macroglossia
Hepatoblastoma
Adrenocoratical neoplasms
Wilm's tumour
Which kidney tumour is a triphasic tumour and why ✅✅Wilm's tumour because in
microscopy it has 3 elements
Epithelial : As gland/rosette formation/tubules
Mesangial : As spindle shaped cells
Blastemal : Primitive element
Due to presence of blastemal component what kind of tumour is Wilm's tumour
✅✅Small round blue cell tumour of childhood
What is the prognostic factor for Wilm's tumour ✅✅Histologic anaplasia if present
then there is poor prognosis, p53 mutation and is chemoresistant
answers
Types of benign kidney tumours ✅✅Angiomyolipoma
Oncocytoma
Type of malignant kidney tumours ✅✅Child : Wilm's tumour
Adult : RCC
What which cells does renal oncocytoma arise form ✅✅Intercalated cells of collecting
duct
Gross appearance of renal oncocytoma ✅✅Tan, mahogany brown kidney
Microscopy of renal oncocytoma ✅✅Cell with abundant eosinophilic granular
cytoplasm with ( due to abundant mitochondria)
Electron microscopy of renal oncocytoma ✅✅Excess of mitochondria
Other diseases with oncocytic cells other than renal oncocytoma ✅✅Hashimoto's
thyroiditis
Which syndrome is associated with renal angiomyolipoma ✅✅Tuberous sclerosis
Which tumours are associated with tuberous sclerosis ✅✅Renal angiomyolipoma
Cardiac rhabdomyoma
What percentage of cardiac rhabdomyomas are associated with tuberous sclerosis
✅✅50%
Spider cells are seen in the microscopy of which cardiac tumour ✅✅Rhabdomyoma
Skin lesions seen in cardiac rhabdomyoma ✅✅Shagreen patch, ash green macule
Microscopy of renal angiomyolipoma ✅✅Blood vessel, muscle, fate
Which renal malignancy occurs in childhood ✅✅Wilm's tumour
What is nephroblastoma ✅✅Wilm's tumour
Age group of Wilm's tumour ✅✅2-5 years
Presenting feature of Wilm's tumour ✅✅Abdominal mass
, What is the genetic component of Wilm's tumour ✅✅WT 1 gene on chr 11p 13
WT 2 gene on chr 11p 15
These are tumour suppressor genes which undergo loss of function mutation
Precursor lesion in Wilm's tumour ✅✅Nephrogenic cell rest
Syndromes associated with Wilm's tumour ✅✅WAGR syndrome
Deny Drash syndrome
Bechwith Weidman syndrome
Components of WAGR syndrome ✅✅Wilm's tumour
Aniridia
Genital abnormalities
mental Retardation
Which Wilm's tumour mutation is seen in Deny Drash syndrome ✅✅WT 1 gene on
chr 11p 13
What are the component of Deny Drash syndrome ✅✅Wilm's tumour
Gonadla dysgenesis
Diffuse mesangial sclerosis
Which Wilm's tumour mutation is present in Bechwith Weidman syndrome ✅✅WT 2
gene on chr 11p 15
Symptoms of Beckwith Weidman syndrome ✅✅Hemihypertrophy (organs in one half
of the body enlarge)
Macroglossia
Hepatoblastoma
Adrenocoratical neoplasms
Wilm's tumour
Which kidney tumour is a triphasic tumour and why ✅✅Wilm's tumour because in
microscopy it has 3 elements
Epithelial : As gland/rosette formation/tubules
Mesangial : As spindle shaped cells
Blastemal : Primitive element
Due to presence of blastemal component what kind of tumour is Wilm's tumour
✅✅Small round blue cell tumour of childhood
What is the prognostic factor for Wilm's tumour ✅✅Histologic anaplasia if present
then there is poor prognosis, p53 mutation and is chemoresistant
