Pharm II Final Exam 2025/2026. 333 Questions And Answers

Pharm II Final Exam
what is the main medication class used to treat dementia ANS: cholinesterase inhibitors



examples of drugs used for dementia and their drug class ANS: Donepezil (Aricept) - cholinesterase
inhibitor



Memantine (Namenda) - NMDA receptor antagonist



Lecanemab (Leqembi) - anti-amyloid monoclonal antibody



Donanemab (Kisunla) - anti-amyloid monoclonal antibody



examples of cholinesterase inhibitors ANS: Donepezil (Aricept)



Rivastigmine (Exelon) - transdermal patch



Galantamine (Razadyne)



cholinesterase inhibitors MOA ANS: - causes reversible inhibition of cholinesterase

--> prevents breakdown of ach

--> raises ach concentrations in the brain



* boosting levels of cell-to-cell communication



how do cholinesterase inhibitors help in treating memory loss ANS: stops the decline in memory for 6-12
months

,does NOT improve memory



after 12 months, memory starts to decline again



also can help with anxiety and depression



what happens if someone stops taking cholinesterase inhibitor ANS: memory will decline quickly back to
how it originally was...can happen within 1-2 weeks



aside from slowing the decline of memory, how else does donepezil (Aricept) treat dementia ANS: treats
behavioral, psychological, and cognitive symptoms of Alzheimer's dementia



donepezil (Aricept) routes of administration ANS: PO



transdermal patch - changed weekly



how long to notice improvements in memory or behavior with donepezil (Aricept) ANS: up to 6 weeks



what can you do if patient is continuing to worsen when taking donepezil (Aricept) ANS: increase dose



donepezil (Aricept) side effects ANS: GI upset



vivid dreams and insomnia



donepezil (Aricept) overdose signs/symptoms ANS: nausea/vomiting

,excess salivation



hypotension



bradycardia



collapse



convulsions



muscle weakness



memantine (Namenda) is approved for... ANS: moderate or severe memory impairment



should you start with the immediate or extended release when prescribing memantine (Namenda)?
ANS: immediate



when to time memantine (Namenda) with meals ANS: you don't have too...absorption is not affected by
food



when does memantine (Namenda) lose its effectiveness ANS: after 6 months



memantine (Namenda) side effects ANS: dizziness



confusion

, ** rare



How is lecanemab (Leqembi) administered? ANS: IV infusion every 2 weeks



lecanemab (Leqembi) MOA ANS: anti-amyloid monoclonal antibody



lecanemab (Leqembi) side effects ANS: fever



flu-like symptoms



nausea/vomiting



dizziness



changes in HR



trouble breathing



how is donanemab (Kisunla) administered ANS: IV infusion every 4 weeks



donanemab (Kisunla) MOA ANS: anti-amyloid monoclonal antibody



donanemab (Kisunla) side effects ANS: flu-like symptoms