DBB TEST 8 QUESTIONS WITH DETAILED
VERIFIED ANSWERS
What is pharmacodynamics?
subfield of pharmacology dealing with the study of the biochemical effects of drugs and their
mechanism of action.
what the drug does to the body
Define receptor
the molecule(s) a drug (or other ligand) interacts with to initiate its biological effects
What is an agonist
drugs that bind to receptors and cause a biological response
they have intrinsic activity (which means they do something)
Is the lock and key analogy actually a good analogy?
Not really as drugs bind to many different types of receptors even if they do not have a
completely complimentary shape.
Do drugs produce a new or unique biological effect?
No, they modify the rate of ongoing cellular events
Receptors are not there to mediate effects of drugs, but effects of endogenous ligands
What types of receptors do most psychoactive drugs act on?
Membrane bound receptors
What type of chemical bonds are present in drug-receptor interactions?
Usually non-covalent bonds
What is the advantage of non-covalent chemical bonds?
Means the drug can unbind easily so not always attached the the receptor
, Define affinity of a drug
How easily it binds to a receptor
What is Kd?
Rate of dissociation
What is the relationship between affinity and Kd
If the rate of dissociation(Kd) is higher then affinity is lower
They are inversely proportional
Which receptors does MDMA have the greatest affinity at?
Seretonin
NA
DA
What is the relationship between drug effect and receptor binding?
The magnitude of the drug effect is proportional to the number of receptors occupied.
When does a drug produce a maximal effect?
when all receptors occupied
What is the Law of Mass action?
A drug produces maximal effect when all receptors occupied.
Once these are all occupied then the drug cannot cause anymore effect because all the receptors
are occupied
This is shown by a dose response curve
What is the ED50 of a drug?
dose that produces response in 50% of subjects
What is the ED100 of a drug?
dose that produces response in 100% of subjects
VERIFIED ANSWERS
What is pharmacodynamics?
subfield of pharmacology dealing with the study of the biochemical effects of drugs and their
mechanism of action.
what the drug does to the body
Define receptor
the molecule(s) a drug (or other ligand) interacts with to initiate its biological effects
What is an agonist
drugs that bind to receptors and cause a biological response
they have intrinsic activity (which means they do something)
Is the lock and key analogy actually a good analogy?
Not really as drugs bind to many different types of receptors even if they do not have a
completely complimentary shape.
Do drugs produce a new or unique biological effect?
No, they modify the rate of ongoing cellular events
Receptors are not there to mediate effects of drugs, but effects of endogenous ligands
What types of receptors do most psychoactive drugs act on?
Membrane bound receptors
What type of chemical bonds are present in drug-receptor interactions?
Usually non-covalent bonds
What is the advantage of non-covalent chemical bonds?
Means the drug can unbind easily so not always attached the the receptor
, Define affinity of a drug
How easily it binds to a receptor
What is Kd?
Rate of dissociation
What is the relationship between affinity and Kd
If the rate of dissociation(Kd) is higher then affinity is lower
They are inversely proportional
Which receptors does MDMA have the greatest affinity at?
Seretonin
NA
DA
What is the relationship between drug effect and receptor binding?
The magnitude of the drug effect is proportional to the number of receptors occupied.
When does a drug produce a maximal effect?
when all receptors occupied
What is the Law of Mass action?
A drug produces maximal effect when all receptors occupied.
Once these are all occupied then the drug cannot cause anymore effect because all the receptors
are occupied
This is shown by a dose response curve
What is the ED50 of a drug?
dose that produces response in 50% of subjects
What is the ED100 of a drug?
dose that produces response in 100% of subjects
