UAMS Hematology Exam #4 UPDATED
ACTUAL Exam Questions and CORRECT
Answers
Less than 5% bands, 50-70% segmented. - CORRECT ANSWER - What types of
neutrophils are in the PB?
Circulating neutrophils - CORRECT ANSWER - Which group of neutrophils are in the
PB, ready to go into the tissue? This is the only group counted in the differential.
Marginating neutrophils - CORRECT ANSWER - Which group of neutrophils are
adjacent to the endothelial lining of the vessel and can be mobilized into the blood by
epinephrine or go into the tissue?
Macrophages in the spleen - CORRECT ANSWER - Neutrophils remaining in the PB
after 2 days are removed by what?
Primary - appear first in promyelocytes
Secondary - appear second in myelocytes
Tertiary - last to appear, not visible on most stains. Only primary and secondary seen with
Wright's stain - CORRECT ANSWER - What are the 3 types of granules and when do
they appear? Which granules can be seen with the Wright's stain?
Primary, contain myeloperoxidase that aids in killing microbes. Purpose of primary granules is to
activate proteinases to kill bacteria. - CORRECT ANSWER - Which granules are also
called azurophilic or non specific? What do these contain and what is the purpose?
Secondary, contain lysozymes that hydrolyze bacteria cell wall and helps with inflammation -
CORRECT ANSWER - Which granules are specific? What do these contain and what
does it do?
, Increased or recurrent infections occur because cell is unable to kill bacteria. - CORRECT
ANSWER - What happens if primary and secondary granules are absent?
The ingestion and destruction of invading microbes, that occurs in the cytoplasm. Nucleus is
involved in cell reproduction, not immunity. - CORRECT ANSWER - What is the primary
function of the neutrophil?
In the BM and PB, majority in BM - CORRECT ANSWER - Where are granulocytes
found?
Cells in circulation go into the tissue and BM releases mature cells. Stem cells commit to
granulocytes and maturation rates increase. Extra cell division occurs to get more cells. Blasts
will never be seen. - CORRECT ANSWER - What happens during an infection? What will
never be seen in the PB during an infection?
Chemotaxis - cell goes to site
Opsonization - cell recognizes organism
Phagocytosis - ingests organism
Degranulation/fusion
Killing
Inflammation - CORRECT ANSWER - What are the steps of phagocytosis?
Neutrophils attracted to infection site by chemotactic factor. Neutrophils bind to chemotactic
factor and go to area of infection. Cells pass through vessel wall between endothelial cells
(diapedesis) - CORRECT ANSWER - What happens during chemotaxis?
Neutrophil recognizes ABY or complement coated organism. Bacteria with a capsule -
CORRECT ANSWER - What happens during opsonization? What can resist recognition?
Neutrophil ingests opsonized organism by surrounding it and moving it with pseudopods.
Pseudopods will meet and fuse to form phagosome. - CORRECT ANSWER - What
happens during phagocytosis?
ACTUAL Exam Questions and CORRECT
Answers
Less than 5% bands, 50-70% segmented. - CORRECT ANSWER - What types of
neutrophils are in the PB?
Circulating neutrophils - CORRECT ANSWER - Which group of neutrophils are in the
PB, ready to go into the tissue? This is the only group counted in the differential.
Marginating neutrophils - CORRECT ANSWER - Which group of neutrophils are
adjacent to the endothelial lining of the vessel and can be mobilized into the blood by
epinephrine or go into the tissue?
Macrophages in the spleen - CORRECT ANSWER - Neutrophils remaining in the PB
after 2 days are removed by what?
Primary - appear first in promyelocytes
Secondary - appear second in myelocytes
Tertiary - last to appear, not visible on most stains. Only primary and secondary seen with
Wright's stain - CORRECT ANSWER - What are the 3 types of granules and when do
they appear? Which granules can be seen with the Wright's stain?
Primary, contain myeloperoxidase that aids in killing microbes. Purpose of primary granules is to
activate proteinases to kill bacteria. - CORRECT ANSWER - Which granules are also
called azurophilic or non specific? What do these contain and what is the purpose?
Secondary, contain lysozymes that hydrolyze bacteria cell wall and helps with inflammation -
CORRECT ANSWER - Which granules are specific? What do these contain and what
does it do?
, Increased or recurrent infections occur because cell is unable to kill bacteria. - CORRECT
ANSWER - What happens if primary and secondary granules are absent?
The ingestion and destruction of invading microbes, that occurs in the cytoplasm. Nucleus is
involved in cell reproduction, not immunity. - CORRECT ANSWER - What is the primary
function of the neutrophil?
In the BM and PB, majority in BM - CORRECT ANSWER - Where are granulocytes
found?
Cells in circulation go into the tissue and BM releases mature cells. Stem cells commit to
granulocytes and maturation rates increase. Extra cell division occurs to get more cells. Blasts
will never be seen. - CORRECT ANSWER - What happens during an infection? What will
never be seen in the PB during an infection?
Chemotaxis - cell goes to site
Opsonization - cell recognizes organism
Phagocytosis - ingests organism
Degranulation/fusion
Killing
Inflammation - CORRECT ANSWER - What are the steps of phagocytosis?
Neutrophils attracted to infection site by chemotactic factor. Neutrophils bind to chemotactic
factor and go to area of infection. Cells pass through vessel wall between endothelial cells
(diapedesis) - CORRECT ANSWER - What happens during chemotaxis?
Neutrophil recognizes ABY or complement coated organism. Bacteria with a capsule -
CORRECT ANSWER - What happens during opsonization? What can resist recognition?
Neutrophil ingests opsonized organism by surrounding it and moving it with pseudopods.
Pseudopods will meet and fuse to form phagosome. - CORRECT ANSWER - What
happens during phagocytosis?
