NURS
549 – Midterm Exam Questions With Answers
/ / / / / / /
Pediatric /Pharmacokinetics /- /correct /answer(s) /✔✔ /-more /sensitive /under /the /age /of /1 /y/o
-intense/prolonged /responses /
-increased /r/f /side /effects
-age-related /unique /side /effects
Absorption /- /correct /answer(s) /✔✔ /-oral, /IM, /transdermal
-peds /have /bigher /gastric /pH /until /3 /y/o
-peds /have /slowed /gastric /emptying /until /6-8 /m/o
Distribution /- /correct /answer(s) /✔✔ /-decreased /protein /binding
-immature /blood-brain /barrier
-total /body /70-80% /water /in /FT /infants
Hepatic /Metabolism /- /correct /answer(s) /✔✔ /-immature /liver
-doesn't /produce /enough /enzymes
-older /children /may /req /higher /dosing /due /to /inc /metabolism
Renal /Excretion /- /correct /answer(s) /✔✔ /-
immature /kidneys /affect /glomerularfiltration /and /tubular /secretion /
-Dec /perfusion /rate
-renal /clearance /reaches /adult /levels /@ /2 /y/o
, Transdermal /Absorption /- /correct /answer(s) /✔✔ /-
infants /= /thin /stratum /corneum /& /greater /blood /flow /to /skin
-at /inc /r/f /toxicity
Hepatic /Metabolism /in /Neonates /- /correct /answer(s) /✔✔ /-especially /sensitive /with /low /drug-
metabolizing /capacity
-inc /rapidly /at /1 /m/o
-liver /matures /completely /at /1 /y/o
Fewer /albumin /proteins /- /correct /answer(s) /✔✔ /Greater /concentration /of /free /drug
Elevated /free /drug /levels /- /correct /answer(s) /✔✔ /More /intense /response
Decreased /hepatic /metabolism /- /correct /answer(s) /✔✔ /Prolonged /response
Decreased /renal /elimination /- /correct /answer(s) /✔✔ /Prolonged /response
Medication /times /for /breastfeeding /mothers /- /correct /answer(s) /✔✔ /-30-60min /after /feeding
-3-4 /hours /before /next /feeding
Contraindicated /meds /during /breastfeeding /- /correct /answer(s) /✔✔ /-tetracyclines
-chemotherapy
-lithium /
-diazepam
Potency /-
/correct /answer(s) /✔✔ /How /much /a /drug /is /needed /to /produce /a /biological /response
549 – Midterm Exam Questions With Answers
/ / / / / / /
Pediatric /Pharmacokinetics /- /correct /answer(s) /✔✔ /-more /sensitive /under /the /age /of /1 /y/o
-intense/prolonged /responses /
-increased /r/f /side /effects
-age-related /unique /side /effects
Absorption /- /correct /answer(s) /✔✔ /-oral, /IM, /transdermal
-peds /have /bigher /gastric /pH /until /3 /y/o
-peds /have /slowed /gastric /emptying /until /6-8 /m/o
Distribution /- /correct /answer(s) /✔✔ /-decreased /protein /binding
-immature /blood-brain /barrier
-total /body /70-80% /water /in /FT /infants
Hepatic /Metabolism /- /correct /answer(s) /✔✔ /-immature /liver
-doesn't /produce /enough /enzymes
-older /children /may /req /higher /dosing /due /to /inc /metabolism
Renal /Excretion /- /correct /answer(s) /✔✔ /-
immature /kidneys /affect /glomerularfiltration /and /tubular /secretion /
-Dec /perfusion /rate
-renal /clearance /reaches /adult /levels /@ /2 /y/o
, Transdermal /Absorption /- /correct /answer(s) /✔✔ /-
infants /= /thin /stratum /corneum /& /greater /blood /flow /to /skin
-at /inc /r/f /toxicity
Hepatic /Metabolism /in /Neonates /- /correct /answer(s) /✔✔ /-especially /sensitive /with /low /drug-
metabolizing /capacity
-inc /rapidly /at /1 /m/o
-liver /matures /completely /at /1 /y/o
Fewer /albumin /proteins /- /correct /answer(s) /✔✔ /Greater /concentration /of /free /drug
Elevated /free /drug /levels /- /correct /answer(s) /✔✔ /More /intense /response
Decreased /hepatic /metabolism /- /correct /answer(s) /✔✔ /Prolonged /response
Decreased /renal /elimination /- /correct /answer(s) /✔✔ /Prolonged /response
Medication /times /for /breastfeeding /mothers /- /correct /answer(s) /✔✔ /-30-60min /after /feeding
-3-4 /hours /before /next /feeding
Contraindicated /meds /during /breastfeeding /- /correct /answer(s) /✔✔ /-tetracyclines
-chemotherapy
-lithium /
-diazepam
Potency /-
/correct /answer(s) /✔✔ /How /much /a /drug /is /needed /to /produce /a /biological /response
