Organic Medicinal and Pharmaceutical Chemistry (PCHEM 2) exam questions with correct answers

Organic Medicinal and Pharmaceutical \| \| \| \|




Chemistry (PCHEM 2) exam questions \| \| \| \| \|




with correct answers \| \|




It is a comparatively weak antitubercular drug; its principal use is as the
\| \| \| \| \| \| \| \| \| \| \| \| \|




secondary drug to avoid resistance problems:
\| \| \| \| \|




a. Rifampicin
\|




b. Isoniazid
\|




c. Ethambutol
\|




d. Pyrazinamide - CORRECT ANSWERS ✔✔Ethambutol
\| \| \| \| \|




Responsible for the broad spectrum activity of amoxicillin and ampicillin
\| \| \| \| \| \| \| \| \|




a. Benzyl group
\| \|




b. Amino group
\| \| \|




c. Hydroxyl group
\| \|




d. Methyl group - CORRECT ANSWERS ✔✔Amino group
\| \| \| \| \| \| \|




It is the most powerful and active antitubercular drug
\| \| \| \| \| \| \| \| \|

,a. Rifampicin
\|




b. Isoniazid
\|




c. Ethambutol
\|




d. Pyrazinamide - CORRECT ANSWERS ✔✔Isoniazid
\| \| \| \| \|




Macrolides are basic due to \| \| \| \| \|




a. Dimethylamino
\|




b. Ketone group
\| \|




c. Large lactone ring
\| \| \|




d. Oleifinic groups - CORRECT ANSWERS ✔✔Dimethylamino
\| \| \| \| \| \|




MRSA is a developed antimicrobial resistance known worldwide. MRSA is an
\| \| \| \| \| \| \| \| \| \| \|




issue to what group of penicillin?
\| \| \| \| \|




a. Aminopenicillin
\|




b. Isoxazolylpenicillin
\|




c. Carboxypenicillin
\|




d. Ureidopenicillin - CORRECT ANSWERS ✔✔Isoxazolylpenicillin
\| \| \| \| \|




Bacitracin is a cyclic polypeptide antibiotic that prevents
\| \| \| \| \| \| \| \|




a. Phosphorylation of the phospholipid that carries the peptidoglycan subunit
\| \| \| \| \| \| \| \| \|

,b. Dephosphorylation of the phospholipid that carries the peptidoglycan
\| \| \| \| \| \| \| \| \|




subunit

c. Decarboxylation of the phospholipid that carries the peptidoglycan subunit
\| \| \| \| \| \| \| \| \|




d. Carboxylation of the phospholipid that carries the peptidoglycan subunit -
\| \| \| \| \| \| \| \| \| \| \|




CORRECT ANSWERS ✔✔Dephosphorylation of the phospholipid that carries
\| \| \| \| \| \| \| \|




the peptidoglycan subunit
\| \|




Which of the following statements is not a property of carbepenems?
\| \| \| \| \| \| \| \| \| \|




a. Meropenem is similar to imepenem in pharmacology and antimicrobial
\| \| \| \| \| \| \| \| \| \|




spectrum of activity \| \|




b. Imipenem is susceptible to beta lactamases and inactivated
\| \| \| \| \| \| \| \| \|




dehydropeptidases in renal tubules \| \| \|




c. Doripenem is the most recent carbepenem to be approved for use
\| \| \| \| \| \| \| \| \| \| \|




d. Ertapenem has a long half-life suitable for once-daily administration -
\| \| \| \| \| \| \| \| \| \| \|




CORRECT ANSWERS ✔✔Imipenem is susceptible to beta lactamases and
\| \| \| \| \| \| \| \| \|




inactivated dehydropeptidases in renal tubules
\| \| \| \|




Has a potent antibacterial activity with transient inhibition of beta-lactamase
\| \| \| \| \| \| \| \| \|




a. Class I
\| \|




b. Class II
\| \|




c. Class III
\| \|




d. Class IV - CORRECT ANSWERS ✔✔Class II
\| \| \| \| \| \| \|

, A prodrug of urinary antiseptic
\| \| \| \| \|




a. Methenamine
\|




b. Fosfomycin
\|




c. Nalidixic acid
\| \| \|




d. Nitrofurantoin
\|




Methenamine - CORRECT ANSWERS ✔✔Methenamine
\| \| \| \|




Four annulated six- membered rings
\| \| \| \|




a. Lactone
\|




b. Octahydronanaphthacene
\|




c. Dihydrothiazine
\|




d. Thiazoladine - CORRECT ANSWERS ✔✔Octahydronanaphthacene
\| \| \| \| \|




Tumor viruses
\|




a. HPV
\|




b. HIV
\|




c. HSV
\|




d. HAV - CORRECT ANSWERS ✔✔HPV
\| \| \| \| \|




Viral taxonomy based on genome
\| \| \| \|