NR565 ADVANCED PHARMACOLOGY
FUNDAMENTALS MIDTERM AND FINAL EXAM
STUDY GUIDE 300 QUESTIONS AND 100 %
CORRECT ANSWERS RATED A QUIZ BANK
LATEST, 2025 CHAMBERLAIN COLLEGE
Pharmacokinetics - CORRECT ANSWER ✔️ The process by
which drugs are absorbed, distributed within the body,
metabolized, and excreted.
Pharmacodynamics - CORRECT ANSWER ✔️ The study of what
the drug does to the body
Factors Affecting Drug Absorption - CORRECT ANSWER ✔️
Rate of dissolution
Surface area
Blood flow
Lipid solubility pH
partitioning
Factors Affecting Drug Distribution - CORRECT ANSWER ✔️
Blood flow to tissues
Ability to exit the vascular system
Blood-brain barrier
Protein-binding capacity
,Xenobiotics - CORRECT ANSWER ✔️ substances that are
foreign to the body, usually synthetic chemical compounds;
medications are a common example
Cytochrome P450 (CYP450) - CORRECT ANSWER ✔️
xenobiotic-metabolizing enzymes necessary for the production of
cholesterol and steroids and the detoxification of chemicals and
drug metabolism.
Function of Cytochrome P450 (CYP450) - CORRECT ANSWER
✔️ responsible for phase 1 metabolism in which drugs are
oxidized, reduced, or hydrolyzed
Phase 1 Metabolism of Drugs via P450 - CORRECT ANSWER
✔️ Oxidation; Reduction; Hydrolysis
Three possible outcomes of phase 1 drug metabolism. -
CORRECT ANSWER ✔️ -Drug becomes completely inactive
-Drug becomes partially inactive but one or more metabolites
remain active
-Original drug is not pharmacologically active but one metabolite
remains active
,CYP450 Inducers - CORRECT ANSWER ✔️ Medications that
can increase the rate of another drug's metabolism by elevating
CYP450 enzyme activity via increasing enzyme synthesis.
decreasing the concentration of the "parent drug"
CYP450 Inducer Medications - CORRECT ANSWER ✔️
CRAPGPS
Carbamazepine
Rifampin
Alcohol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas
CYP450 Inhibitors - CORRECT ANSWER ✔️ Medications that
inhibit the metabolic activity of one or more of the CYP450
enzymes. Higher risk for toxicity; prolongs the pharmacological
effect of the "parent drug".
CYP450 Inhibitor Medications - CORRECT ANSWER ✔️
VISACKGQ
Valproate
Isoniazid
, Sulfonamides
Amiodarone
Chloramphenicol
Ketoconazole
Grapefruit Juice
Quinidine
Beers Criteria - CORRECT ANSWER ✔️ -potentially
Inappropriate Medication (PIM) use in older adults
-potentially Inappropriate Medication (PIM) use in older adults due
to medication-disease or medication-syndrome interactions that
may exacerbate the disease or syndrome -medications to be used
cautiously in older adults
-clinically significant drug interactions that should be avoided in
older adults
-medications to be avoided or dosage decreased in the presence
of impaired kidney function in older adults
Pharmacokinetic Interactions - CORRECT ANSWER ✔️
when
one medication systemically alters the potency of another
medication.
Absorption Interaction - CORRECT ANSWER ✔️ result of a
FUNDAMENTALS MIDTERM AND FINAL EXAM
STUDY GUIDE 300 QUESTIONS AND 100 %
CORRECT ANSWERS RATED A QUIZ BANK
LATEST, 2025 CHAMBERLAIN COLLEGE
Pharmacokinetics - CORRECT ANSWER ✔️ The process by
which drugs are absorbed, distributed within the body,
metabolized, and excreted.
Pharmacodynamics - CORRECT ANSWER ✔️ The study of what
the drug does to the body
Factors Affecting Drug Absorption - CORRECT ANSWER ✔️
Rate of dissolution
Surface area
Blood flow
Lipid solubility pH
partitioning
Factors Affecting Drug Distribution - CORRECT ANSWER ✔️
Blood flow to tissues
Ability to exit the vascular system
Blood-brain barrier
Protein-binding capacity
,Xenobiotics - CORRECT ANSWER ✔️ substances that are
foreign to the body, usually synthetic chemical compounds;
medications are a common example
Cytochrome P450 (CYP450) - CORRECT ANSWER ✔️
xenobiotic-metabolizing enzymes necessary for the production of
cholesterol and steroids and the detoxification of chemicals and
drug metabolism.
Function of Cytochrome P450 (CYP450) - CORRECT ANSWER
✔️ responsible for phase 1 metabolism in which drugs are
oxidized, reduced, or hydrolyzed
Phase 1 Metabolism of Drugs via P450 - CORRECT ANSWER
✔️ Oxidation; Reduction; Hydrolysis
Three possible outcomes of phase 1 drug metabolism. -
CORRECT ANSWER ✔️ -Drug becomes completely inactive
-Drug becomes partially inactive but one or more metabolites
remain active
-Original drug is not pharmacologically active but one metabolite
remains active
,CYP450 Inducers - CORRECT ANSWER ✔️ Medications that
can increase the rate of another drug's metabolism by elevating
CYP450 enzyme activity via increasing enzyme synthesis.
decreasing the concentration of the "parent drug"
CYP450 Inducer Medications - CORRECT ANSWER ✔️
CRAPGPS
Carbamazepine
Rifampin
Alcohol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas
CYP450 Inhibitors - CORRECT ANSWER ✔️ Medications that
inhibit the metabolic activity of one or more of the CYP450
enzymes. Higher risk for toxicity; prolongs the pharmacological
effect of the "parent drug".
CYP450 Inhibitor Medications - CORRECT ANSWER ✔️
VISACKGQ
Valproate
Isoniazid
, Sulfonamides
Amiodarone
Chloramphenicol
Ketoconazole
Grapefruit Juice
Quinidine
Beers Criteria - CORRECT ANSWER ✔️ -potentially
Inappropriate Medication (PIM) use in older adults
-potentially Inappropriate Medication (PIM) use in older adults due
to medication-disease or medication-syndrome interactions that
may exacerbate the disease or syndrome -medications to be used
cautiously in older adults
-clinically significant drug interactions that should be avoided in
older adults
-medications to be avoided or dosage decreased in the presence
of impaired kidney function in older adults
Pharmacokinetic Interactions - CORRECT ANSWER ✔️
when
one medication systemically alters the potency of another
medication.
Absorption Interaction - CORRECT ANSWER ✔️ result of a
