ABSITE OPERATIVE TECHNIQUES: COMMON
PROCEDURES, BEST PRACTICES, AND
INTRAOPERATIVE DECISION-MAKING
[Document subtitle]
, ABSITE Operative Techniques: Common
Procedures, Best Practices, and Intraoperative
Decision-Making
1.A 67 year old man is found to have a submucosal 5 cm tumour in the body of his stomach.
The treating
physician considers that this may be a gastrointestinal stromal tumour (GIST). Which one
of the following statements is correct?
a.) this tumour has a propensity to spread to lymph nodes
b.) this tumour is benign and unlikely to metastasize
c.) GIST is from mutations in c-KIT C Platelet-derived growth factor (PDGF)
d.) the tumour is very aggressive and survival is normally limited
mutation in c-KIT (95%) and in Platelet-derived growth factor (PDGF), NOT nodes (sarcoma)
→ liver, lungs, periotoneum
2.What is the mechanism action of the chemotherapeutic agent used in treating GIST?
1
, a.) G-coupled protein receptor inhibitor
b.) CAMP inhibition
c.) Tyrosine kinase inhibitor
d.) Steroid synthesis
Gleevac → targeted tyrosine kinase inhibitor aimed at c-KIT mutation
3.What marker distinguishes GIST from leiomyoma/leiomyosarcoma?
a.) n-myc
b.) c-KIT
c.) MSH
d.) APC
4.Damage to one recurrent laryngeal nerve
during thyroidectomy generally leads to:
a.) the need for a tracheostomy
b.) an inability to sing high notes
c.) inability to project the voice to the back of a hall
d.) a falsetto voice
e.) a hoarse voice -
5.The standard surgical treatment of a gastrointestinal stromal tumor (GIST) of the
stomach is which of the following?
2
PROCEDURES, BEST PRACTICES, AND
INTRAOPERATIVE DECISION-MAKING
[Document subtitle]
, ABSITE Operative Techniques: Common
Procedures, Best Practices, and Intraoperative
Decision-Making
1.A 67 year old man is found to have a submucosal 5 cm tumour in the body of his stomach.
The treating
physician considers that this may be a gastrointestinal stromal tumour (GIST). Which one
of the following statements is correct?
a.) this tumour has a propensity to spread to lymph nodes
b.) this tumour is benign and unlikely to metastasize
c.) GIST is from mutations in c-KIT C Platelet-derived growth factor (PDGF)
d.) the tumour is very aggressive and survival is normally limited
mutation in c-KIT (95%) and in Platelet-derived growth factor (PDGF), NOT nodes (sarcoma)
→ liver, lungs, periotoneum
2.What is the mechanism action of the chemotherapeutic agent used in treating GIST?
1
, a.) G-coupled protein receptor inhibitor
b.) CAMP inhibition
c.) Tyrosine kinase inhibitor
d.) Steroid synthesis
Gleevac → targeted tyrosine kinase inhibitor aimed at c-KIT mutation
3.What marker distinguishes GIST from leiomyoma/leiomyosarcoma?
a.) n-myc
b.) c-KIT
c.) MSH
d.) APC
4.Damage to one recurrent laryngeal nerve
during thyroidectomy generally leads to:
a.) the need for a tracheostomy
b.) an inability to sing high notes
c.) inability to project the voice to the back of a hall
d.) a falsetto voice
e.) a hoarse voice -
5.The standard surgical treatment of a gastrointestinal stromal tumor (GIST) of the
stomach is which of the following?
2
