ABRAM’S CLINICAL DRUG THERAPY RATIONALES FOR
NURSING PRACTICE 13th EDITION GERALYN FRANDSEN’S GUIDE 2024-2025
,Chapter 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s
1. A patient diagnosed with obsessive–
s s s s
compulsive disorder has been prescribed oralparoxetine hydrochloride. What is the e
s s s s s s s s s s s
xpected effect for this prescription? s s s s
A. Curative effect on symptoms s s s
B. Systemic effect on symptoms s s s
C. Local effect on symptoms s s s
D. Parenteral effect on symptoms s s s
ACCURATE ANSWER:-B s
REASONING:-
>>>Pharmaceutical drug that produce systemic effects are taken into the body, circulated throu s s s s s s s s s s s s
gh the bloodstream to their sites of action in various body tissues, and eventually eliminated fro
s s s s s s s s s s s s s s s
m the body. Curative agents are given to cure a disease process. Inthis case, paroxetine hydrochl
s s s s s s s s s s s s s s s s
oride will control the symptoms but not cure the disorder.
s s s s s s s s s
Pharmaceutical drug with local effects, such as sunscreen and local anesthetics, act mainly at th s s s s s s s s s s s s s s
e siteof application. Paroxetine hydrochloride is not administered parenterally. Parenteral age
s s s s s s s s s s s
ntsare administered subcutaneously, intramuscularly, or intravenously.
s s s s s s
POINTS: 1 REFERENCE: p. 3, Introduction OBJ: 1 s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Processs s s s
BLM: Cognitive Level: Understand sNOT: Multiple Choice s s s s
2. A hospital client has been prescribed an antibiotic. This pharmaceutical drug is a natu
s s s s s s s s s s s s s
rally occurringsubstance that has been cheG
s mRicA
alDlyEm
SoBdOifOieSd.TW
.C
haOt Mi s another name for t s s s s s ss s ss s s s
his type of pharmaceutical drug?
s s s s
A. Synthetic drug s
B. Semisynthetic drug s
C. Biotechnology drug s
D. Prototype drug s
ACCURATE ANSWER:-B s
REASONING:-
>>>Semisynthetic pharmaceutical drug (e.g., many antibiotics) are naturally occurring subst s s s s s s s s s
ances that have been chemically modified. Synthetic pharmaceutical drug are more standardi
s s s s s s s s s s s
zed in their chemical characteristics, more consistent in their effects, and less likely to produce
s s s s s s s s s s s s s s
allergic reactions. Biotechnology pharmaceutical drug involve manipulating DNAand RNA
s s s s s s s s s s s
and recombining genes into hybrid molecules that can be inserted into living organisms. Proto
s s s s s s s s s s s s s
type pharmaceutical drug are the first drug of a particular group to be developed.
s s s s s s s s s s s s s
POINTS: 1 REFERENCE: p. 3, Drug Sources OBJ: 1 s s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Processs s s s
BLM: Cognitive Level: Understand sNOT: Multiple Choice s s s s
3. Which classification applies to morphine? s s s s
A. Central nervous system depressant s s s
B. Central nervous system stimulant s s s
, C. Anti-inflammatory
D. Antihypertensive
ACCURATE ANSWER:-A s
REASONING:-
>>>Pharmaceutical drug are classified according to their effects on particular body systems, th s s s s s s s s s s s s
eir therapeutic uses, and their chemical characteristics. Morphine is classified as a central nervo
s s s s s s s s s s s s s
us system depressant and will produce this effect in the hospital client. Acentral nervous system
s s s s s s s s s s s s s s s s
stimulant increases attention and raises mood. An anti-
s s s s s s s
inflammatoryagent decreases inflammation at the site of tissue or joint inflammation. An antihy
s s s s s s s s s s s s s
pertensiveagent reduces blood pressure. s s s s
POINTS: 1 REFERENCE:
p. 3, Drug Classifications and PrototypesOBJ:
s 1 s s s s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Process
s s s s
BLM: Cognitive Level: Remembers NOT: Multiple Choice s s s s
4. A hospital client is administered amoxicillin. The generic name of this pharmaceutical drug bel
s s s s s s s s s s s s s
ongs to whichdrug group? s s s s
A. Selective serotonin reuptake inhibitors s s s
B. Diuretics
C. Penicillins
D. ACE inhibitors s
ACCURATE ANSWER:-C s
REASONING:->>>The generic name often indicates the drug group (e.g., pharmaceutical drug
GRADESBOOST.CO
with generic names ending in ―cillin‖ are penicillins). Selective serotonin reuptakeinhibit
s s s
s
s s
s
s
s
s
s
s
s s s
s
s
s
s
s
s
ors are pharmaceutical drugs
s s s
that have antidepressant effects; SSRI is a broad classification, not a generic name. Diureticsare p
s s s s s s s s s s s s s s s
harmaceutical drugs that increase urine output; diuretic is a broad classification, not a generic na
s s s s s s s s s s s s s s
me. ACE inhibitor is the broad classification for the angiotensin receptor blockers, not thegeneri
s s s s s s s s s s s s s s
c name.
s
POINTS: 1 REFERENCE: p. 3, Drug Names OBJ: 2 s s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Process
s s s s
BLM: Cognitive Level: Understand
s NOT: Multiple Choice s s s s
5. The administration of diphenhydramine is regulated by which U.S. government agency?
s s s s s s s s s s
A. Public Health Service s s
B. Federal Trade Commission s s
C. Occupational Safety and Health Administration s s s s
D. Food and Drug s s s
Administration
ACCURATE ANSWER:-D s
, REASONING:-
>>>The Food and Drug Administration approves pharmaceutical drug for over- the-
s s s s s s s s s s
counter availability, including the transfer of pharmaceutical drug from prescription to OTC st
s s s s s s s s s s s s
atus, and may require clinical trials to determine the safety and effectiveness of OTC use.The P
s s s s s s s s s s s s s s s s
ublic Health Service is regulated by the state to maintain the health of individual citizens of the
s s s s s s s s s s s s s s s s s
state. The Federal Trade Commission regulates imports and exports throughout the nation. Th
s s s s s s s s s s s s
e Occupational Safety and Health Administration regulates safetywithin the workplace.
s s s s s s s s s s
POINTS: 1 REFERENCE: p. 4, Prescription and Nonprescription s s s s
Pharmaceutical drug OBJ: 4 s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Process
s s s s
BLM: Cognitive Level: Understand
s NOT: Multiple Choice s s s s
6. In the U.S., the administration of anabolic steroids is regulated by which law?
s s s s s s s s s s s s
A. The Food, Drug, and Cosmetic Act of 1938
s s s s s s s
B. The Comprehensive Drug Abuse Prevention and Control Act
s s s s s s s
C. The Harrison Narcotic Act s s s
D. The Sherley Amendment s s
ACCURATE ANSWER:-B s
REASONING:-
>>>The Comprehensive Drug Abuse Prevention and Control Act regulates the manufacture an
s s s s s s s s s s s
d distribution of narcotics, stimulants, depressants, hallucinogens, and anabolic steroids. The F
s s s s s s s s s s s
ood, Drug, and Cosmetic Act of 1938 revised and broadened FDA powers and responsibilities,
s s s s s s s s s s s s s s
giving the FDA control over drug safety. The Harrison Narcotic Act restricted the importation,
s s s s s s s s s s s s s s
manufacture, sale, and use of opium,cocaine, marijuana, and other pharmaceuticaldrugthat the act
s s s s s s s s s s s s s s s
d e fi Gn eRd AaDs E
s s s naSrcBoO
tiO
csSTh.eCSOhM
.T
s erley Amendment of 1912 prohibited fraudulent claims of drug ef
s s s s s s s s s s s
fectiveness.
POINTS: 1 REFERENCE: p. 4, Prescription and Nonprescription s s s s
Pharmaceutical drug OBJ: 3 s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Process
s s s s
BLM: Cognitive Level: Remember s NOT: Multiple Choice s s s s
7. A nursing attendant is responsible for maintaining an accurate count and record of the cont
s s s s s s s s s s s s s s
rolled substances on the nursing division. This nursing action is regulated by which
s s s s s s s s s s s s
U.S. law or agency?
s s s
A. The Food, Drug, and Cosmetic Act of 1938
s s s s s s s
B. The Public Health Service s s s
C. The Drug Enforcement Administration
s s s
D. The Sherley Amendment s s s
ACCURATE ANSWER:-C s
NURSING PRACTICE 13th EDITION GERALYN FRANDSEN’S GUIDE 2024-2025
,Chapter 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s
1. A patient diagnosed with obsessive–
s s s s
compulsive disorder has been prescribed oralparoxetine hydrochloride. What is the e
s s s s s s s s s s s
xpected effect for this prescription? s s s s
A. Curative effect on symptoms s s s
B. Systemic effect on symptoms s s s
C. Local effect on symptoms s s s
D. Parenteral effect on symptoms s s s
ACCURATE ANSWER:-B s
REASONING:-
>>>Pharmaceutical drug that produce systemic effects are taken into the body, circulated throu s s s s s s s s s s s s
gh the bloodstream to their sites of action in various body tissues, and eventually eliminated fro
s s s s s s s s s s s s s s s
m the body. Curative agents are given to cure a disease process. Inthis case, paroxetine hydrochl
s s s s s s s s s s s s s s s s
oride will control the symptoms but not cure the disorder.
s s s s s s s s s
Pharmaceutical drug with local effects, such as sunscreen and local anesthetics, act mainly at th s s s s s s s s s s s s s s
e siteof application. Paroxetine hydrochloride is not administered parenterally. Parenteral age
s s s s s s s s s s s
ntsare administered subcutaneously, intramuscularly, or intravenously.
s s s s s s
POINTS: 1 REFERENCE: p. 3, Introduction OBJ: 1 s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Processs s s s
BLM: Cognitive Level: Understand sNOT: Multiple Choice s s s s
2. A hospital client has been prescribed an antibiotic. This pharmaceutical drug is a natu
s s s s s s s s s s s s s
rally occurringsubstance that has been cheG
s mRicA
alDlyEm
SoBdOifOieSd.TW
.C
haOt Mi s another name for t s s s s s ss s ss s s s
his type of pharmaceutical drug?
s s s s
A. Synthetic drug s
B. Semisynthetic drug s
C. Biotechnology drug s
D. Prototype drug s
ACCURATE ANSWER:-B s
REASONING:-
>>>Semisynthetic pharmaceutical drug (e.g., many antibiotics) are naturally occurring subst s s s s s s s s s
ances that have been chemically modified. Synthetic pharmaceutical drug are more standardi
s s s s s s s s s s s
zed in their chemical characteristics, more consistent in their effects, and less likely to produce
s s s s s s s s s s s s s s
allergic reactions. Biotechnology pharmaceutical drug involve manipulating DNAand RNA
s s s s s s s s s s s
and recombining genes into hybrid molecules that can be inserted into living organisms. Proto
s s s s s s s s s s s s s
type pharmaceutical drug are the first drug of a particular group to be developed.
s s s s s s s s s s s s s
POINTS: 1 REFERENCE: p. 3, Drug Sources OBJ: 1 s s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Processs s s s
BLM: Cognitive Level: Understand sNOT: Multiple Choice s s s s
3. Which classification applies to morphine? s s s s
A. Central nervous system depressant s s s
B. Central nervous system stimulant s s s
, C. Anti-inflammatory
D. Antihypertensive
ACCURATE ANSWER:-A s
REASONING:-
>>>Pharmaceutical drug are classified according to their effects on particular body systems, th s s s s s s s s s s s s
eir therapeutic uses, and their chemical characteristics. Morphine is classified as a central nervo
s s s s s s s s s s s s s
us system depressant and will produce this effect in the hospital client. Acentral nervous system
s s s s s s s s s s s s s s s s
stimulant increases attention and raises mood. An anti-
s s s s s s s
inflammatoryagent decreases inflammation at the site of tissue or joint inflammation. An antihy
s s s s s s s s s s s s s
pertensiveagent reduces blood pressure. s s s s
POINTS: 1 REFERENCE:
p. 3, Drug Classifications and PrototypesOBJ:
s 1 s s s s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Process
s s s s
BLM: Cognitive Level: Remembers NOT: Multiple Choice s s s s
4. A hospital client is administered amoxicillin. The generic name of this pharmaceutical drug bel
s s s s s s s s s s s s s
ongs to whichdrug group? s s s s
A. Selective serotonin reuptake inhibitors s s s
B. Diuretics
C. Penicillins
D. ACE inhibitors s
ACCURATE ANSWER:-C s
REASONING:->>>The generic name often indicates the drug group (e.g., pharmaceutical drug
GRADESBOOST.CO
with generic names ending in ―cillin‖ are penicillins). Selective serotonin reuptakeinhibit
s s s
s
s s
s
s
s
s
s
s
s s s
s
s
s
s
s
s
ors are pharmaceutical drugs
s s s
that have antidepressant effects; SSRI is a broad classification, not a generic name. Diureticsare p
s s s s s s s s s s s s s s s
harmaceutical drugs that increase urine output; diuretic is a broad classification, not a generic na
s s s s s s s s s s s s s s
me. ACE inhibitor is the broad classification for the angiotensin receptor blockers, not thegeneri
s s s s s s s s s s s s s s
c name.
s
POINTS: 1 REFERENCE: p. 3, Drug Names OBJ: 2 s s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Process
s s s s
BLM: Cognitive Level: Understand
s NOT: Multiple Choice s s s s
5. The administration of diphenhydramine is regulated by which U.S. government agency?
s s s s s s s s s s
A. Public Health Service s s
B. Federal Trade Commission s s
C. Occupational Safety and Health Administration s s s s
D. Food and Drug s s s
Administration
ACCURATE ANSWER:-D s
, REASONING:-
>>>The Food and Drug Administration approves pharmaceutical drug for over- the-
s s s s s s s s s s
counter availability, including the transfer of pharmaceutical drug from prescription to OTC st
s s s s s s s s s s s s
atus, and may require clinical trials to determine the safety and effectiveness of OTC use.The P
s s s s s s s s s s s s s s s s
ublic Health Service is regulated by the state to maintain the health of individual citizens of the
s s s s s s s s s s s s s s s s s
state. The Federal Trade Commission regulates imports and exports throughout the nation. Th
s s s s s s s s s s s s
e Occupational Safety and Health Administration regulates safetywithin the workplace.
s s s s s s s s s s
POINTS: 1 REFERENCE: p. 4, Prescription and Nonprescription s s s s
Pharmaceutical drug OBJ: 4 s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Process
s s s s
BLM: Cognitive Level: Understand
s NOT: Multiple Choice s s s s
6. In the U.S., the administration of anabolic steroids is regulated by which law?
s s s s s s s s s s s s
A. The Food, Drug, and Cosmetic Act of 1938
s s s s s s s
B. The Comprehensive Drug Abuse Prevention and Control Act
s s s s s s s
C. The Harrison Narcotic Act s s s
D. The Sherley Amendment s s
ACCURATE ANSWER:-B s
REASONING:-
>>>The Comprehensive Drug Abuse Prevention and Control Act regulates the manufacture an
s s s s s s s s s s s
d distribution of narcotics, stimulants, depressants, hallucinogens, and anabolic steroids. The F
s s s s s s s s s s s
ood, Drug, and Cosmetic Act of 1938 revised and broadened FDA powers and responsibilities,
s s s s s s s s s s s s s s
giving the FDA control over drug safety. The Harrison Narcotic Act restricted the importation,
s s s s s s s s s s s s s s
manufacture, sale, and use of opium,cocaine, marijuana, and other pharmaceuticaldrugthat the act
s s s s s s s s s s s s s s s
d e fi Gn eRd AaDs E
s s s naSrcBoO
tiO
csSTh.eCSOhM
.T
s erley Amendment of 1912 prohibited fraudulent claims of drug ef
s s s s s s s s s s s
fectiveness.
POINTS: 1 REFERENCE: p. 4, Prescription and Nonprescription s s s s
Pharmaceutical drug OBJ: 3 s s
NAT: Hospital client Needs: Physiological Integrity: Pharmacological and Parenteral The
s s s s s s s s s
rapiesTOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
s s s s s s s s s
KEY: Integrated Process: Nursing Process
s s s s
BLM: Cognitive Level: Remember s NOT: Multiple Choice s s s s
7. A nursing attendant is responsible for maintaining an accurate count and record of the cont
s s s s s s s s s s s s s s
rolled substances on the nursing division. This nursing action is regulated by which
s s s s s s s s s s s s
U.S. law or agency?
s s s
A. The Food, Drug, and Cosmetic Act of 1938
s s s s s s s
B. The Public Health Service s s s
C. The Drug Enforcement Administration
s s s
D. The Sherley Amendment s s s
ACCURATE ANSWER:-C s