SGLT2 Inhibitors AADE questions with verified answers
Can pregnant or nursing women, children, or T2DM take SGLT2
inhibitors? Ans✓✓✓ No.
Describe osmotic diuresis for people on SGLT2 inhibitors. Ans✓✓✓
Worse if already on diuretic ACE inhibitors or ARBs. Get dehydrated
because you lose too much water. Use with caution in elderly. Can
cause orthostatic changes and syncope due to lower blood pressure.
Do not use Cana or Empa if GFR is less than what? Ans✓✓✓ 45.
Do not use Dapa if GFR is less than what? Ans✓✓✓ 60.
Do SGLT2 inhibitors increase insulin secretion? Ans✓✓✓ No.
How do SGLP2 inhibitors work? Ans✓✓✓ Works in the kidneys in the
proximal tubule. SGLT2 inhibitors block reabsorption of glucose back
into the blood and causes excess glucose to go into urine. You pee out
sugar.
How does glucose reabsorption work in people without diabetes?
Ans✓✓✓ All glucose is reabsorbed by the kidneys. No glucose is
excreted in the urine. SGLT2 manages glucose reabsorption.
Can pregnant or nursing women, children, or T2DM take SGLT2
inhibitors? Ans✓✓✓ No.
Describe osmotic diuresis for people on SGLT2 inhibitors. Ans✓✓✓
Worse if already on diuretic ACE inhibitors or ARBs. Get dehydrated
because you lose too much water. Use with caution in elderly. Can
cause orthostatic changes and syncope due to lower blood pressure.
Do not use Cana or Empa if GFR is less than what? Ans✓✓✓ 45.
Do not use Dapa if GFR is less than what? Ans✓✓✓ 60.
Do SGLT2 inhibitors increase insulin secretion? Ans✓✓✓ No.
How do SGLP2 inhibitors work? Ans✓✓✓ Works in the kidneys in the
proximal tubule. SGLT2 inhibitors block reabsorption of glucose back
into the blood and causes excess glucose to go into urine. You pee out
sugar.
How does glucose reabsorption work in people without diabetes?
Ans✓✓✓ All glucose is reabsorbed by the kidneys. No glucose is
excreted in the urine. SGLT2 manages glucose reabsorption.
