UNE Medical Biochemistry Unit 3 Midterm Test
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Which of the following lipoproteins distributes dietary lipids? - ANSWER chylomicron
The interaction of chylomicrons with lipoprotein lipase is stimulated by which of the following
Apo proteins? - ANSWER ApoC II
Nascent chylomicrons are synthesized in which tissue? - ANSWER Intestine
Bile salts are synthesized from cholesterol and are used for the emulsification of dietary lipids.
What is the primary fate of bile salts during digestion? - ANSWER They are reabsorbed in the
ileum
Nascent chylomicrons interact with HDL particles and obtain which of the following Apo
protiens? - ANSWER ApoCII and ApoE
The activity of pancreatic lipase is inhibited by which of the following compounds? - ANSWER
Bile salts
Which of the following statements regarding lipid digestion and absorption is true?
A. The products of lipid digestion travel in the circulatory system in the form of micelles.
,B. The products of lipid digestion diffuse into capillaries in the vicinity of the intestinal
epithelium.
C. Pancreatic lipase emulsifies lipids.
D. The products of lipid digestion are resynthesized into triacylglycerols in intestinal epithelial
cells.
E. In the absence of bile salts, no digestion of lipids would occur. - ANSWER The products of lipid
digestion are resynthesized into triacylglycerols in intestinal epithelial cells.
Under fasting conditions (Ratio of insulin to glucagon <1), elevated glucagon will activate which
of the following enzymes? - ANSWER Hormone sensitive lipase
VLDL particles are characterized by which of the following apoproteins? - ANSWER Apo B 100
An increase in insulin leads to which of the following metabolic shifts? - ANSWER Acetyl CoA
carboxylase will become dephosphorylated and active
Biotin is a cofactor required for which of the following enzymes? - ANSWER A and B (Acetyl CoA
carboxylase and Pyruvate carboxylase)
The first step in fatty acid synthesis is the formation of ________ from acetyl CoA and carbon
dioxide. - ANSWER malonyl CoA
Insulin increases the activity of all of the following enzymes except: - ANSWER Hormone
sensitive lipase
,Which of the following is the regulatory enzyme for fatty acid synthesis? - ANSWER AcetylCo A
carboxylase
Which of the following is the regulated step of fatty acid synthesis in eukaryotes?
A. Carboxylation of acetyl CoA
B. Transportation of mitochondrial acetyl CoA into the cytosol
C. Assembly of the fatty acid chain
D. All of the above - ANSWER Carboxylation of acetyl CoA
Under conditions of starvation, all of the following are true except:
A. the brain will preferentially be oxidizing ketones
B. hormone sensitive lipase will be phosphorylated
C. AMP kinase will be active
D. Malonyl CoA will be elevated - ANSWER Malonyl CoA will be elevated
Which of the following proteins is responsible for the transfer of ApoB48 to nascent
chylomicrons before secretion into circulation? - ANSWER Microsomal transfer protein (MTP)
, The process of β-oxidation generates all of the following compounds except:
A. Acetyl CoA
B. NADPH
C. NADH
D. FADH2 - ANSWER NADPH
During the fasted state, lipolysis is facilitated by the action of hormone sensitive lipase. This
enzyme requires which of the following post - translational modification for activation? -
ANSWER Phosphorylation
Adiponectin is secreted from adipocytes. One of the primary roles of adiponectin is to activate
AMPK in skeletal muscle which enhances the activity of which of the following pathways? -
ANSWER β oxidation
When the processes of glucose oxidation is elevated, the acetyl CoA produced will allosterically
activate which of the following enzymes leading to an increase in the production of
oxaloacetate? - ANSWER Pyruvate carboxylase
The process of ketogenesis refers to the conversion of acetyl CoA to which of the following
compounds? - ANSWER β-hydroxybutyrate
The transport of newly synthesized fatty acids to the adipose requires all of the following
except:
Exam ( Questions With Correct Verified Answers )
100% Verified Answers |Already Graded A+|
Guaranteed Pass!
Which of the following lipoproteins distributes dietary lipids? - ANSWER chylomicron
The interaction of chylomicrons with lipoprotein lipase is stimulated by which of the following
Apo proteins? - ANSWER ApoC II
Nascent chylomicrons are synthesized in which tissue? - ANSWER Intestine
Bile salts are synthesized from cholesterol and are used for the emulsification of dietary lipids.
What is the primary fate of bile salts during digestion? - ANSWER They are reabsorbed in the
ileum
Nascent chylomicrons interact with HDL particles and obtain which of the following Apo
protiens? - ANSWER ApoCII and ApoE
The activity of pancreatic lipase is inhibited by which of the following compounds? - ANSWER
Bile salts
Which of the following statements regarding lipid digestion and absorption is true?
A. The products of lipid digestion travel in the circulatory system in the form of micelles.
,B. The products of lipid digestion diffuse into capillaries in the vicinity of the intestinal
epithelium.
C. Pancreatic lipase emulsifies lipids.
D. The products of lipid digestion are resynthesized into triacylglycerols in intestinal epithelial
cells.
E. In the absence of bile salts, no digestion of lipids would occur. - ANSWER The products of lipid
digestion are resynthesized into triacylglycerols in intestinal epithelial cells.
Under fasting conditions (Ratio of insulin to glucagon <1), elevated glucagon will activate which
of the following enzymes? - ANSWER Hormone sensitive lipase
VLDL particles are characterized by which of the following apoproteins? - ANSWER Apo B 100
An increase in insulin leads to which of the following metabolic shifts? - ANSWER Acetyl CoA
carboxylase will become dephosphorylated and active
Biotin is a cofactor required for which of the following enzymes? - ANSWER A and B (Acetyl CoA
carboxylase and Pyruvate carboxylase)
The first step in fatty acid synthesis is the formation of ________ from acetyl CoA and carbon
dioxide. - ANSWER malonyl CoA
Insulin increases the activity of all of the following enzymes except: - ANSWER Hormone
sensitive lipase
,Which of the following is the regulatory enzyme for fatty acid synthesis? - ANSWER AcetylCo A
carboxylase
Which of the following is the regulated step of fatty acid synthesis in eukaryotes?
A. Carboxylation of acetyl CoA
B. Transportation of mitochondrial acetyl CoA into the cytosol
C. Assembly of the fatty acid chain
D. All of the above - ANSWER Carboxylation of acetyl CoA
Under conditions of starvation, all of the following are true except:
A. the brain will preferentially be oxidizing ketones
B. hormone sensitive lipase will be phosphorylated
C. AMP kinase will be active
D. Malonyl CoA will be elevated - ANSWER Malonyl CoA will be elevated
Which of the following proteins is responsible for the transfer of ApoB48 to nascent
chylomicrons before secretion into circulation? - ANSWER Microsomal transfer protein (MTP)
, The process of β-oxidation generates all of the following compounds except:
A. Acetyl CoA
B. NADPH
C. NADH
D. FADH2 - ANSWER NADPH
During the fasted state, lipolysis is facilitated by the action of hormone sensitive lipase. This
enzyme requires which of the following post - translational modification for activation? -
ANSWER Phosphorylation
Adiponectin is secreted from adipocytes. One of the primary roles of adiponectin is to activate
AMPK in skeletal muscle which enhances the activity of which of the following pathways? -
ANSWER β oxidation
When the processes of glucose oxidation is elevated, the acetyl CoA produced will allosterically
activate which of the following enzymes leading to an increase in the production of
oxaloacetate? - ANSWER Pyruvate carboxylase
The process of ketogenesis refers to the conversion of acetyl CoA to which of the following
compounds? - ANSWER β-hydroxybutyrate
The transport of newly synthesized fatty acids to the adipose requires all of the following
except:
