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Sorsby Fundus Dystrophy (SFD) Il` Il` Il`
Similar symptoms to AMD, but can start at a much younger age. Inherited in an autosomal fashion
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(faulty gene from either parent.) A progressive autosomal dominant macular dystrophy.
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Characteristics:
- thick drusen-like deposits between the inner collagenous layer of Bruch’s membrane and the
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basement membrane of the retinal pigment epithelium (RPE).
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- Slit lamp examination typically reveals drusen deposition in the posterior pole and along vascular
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arcades, although reticular drusen may also be seen. These drusen are described as yellow,
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extracellular deposits between Bruch’s membrane and the RPE.
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Early symptoms are night blindness (Nyctalopia) and difficulty distinguishing between green and
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blue red and yellow.
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Later on macular cells die off, new blood vessels form, and central vision loss can occur.
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No proven treatment, but anti-VEGF injections can sometimes slow new blood vessel growth.
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Testing: OCT. FA. FAF. Fundus Images. Il` Il` Il` Il` Il`
Background Diabetic Retinopathy Il` Il`
Another name for NON proliferative Diabetic retinopathy, early stage of the disease.
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AD
Proliferative Diabetic Retinopathy (PDR) Il` Il` Il`
The final and most severe stage of this disease. Has all the other factors of the lesser stages except
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this stage has Neovascularization (development of new, weaker blood vessels) and/or
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vitreous/pre retinal hemorrhage.
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,Neovascularization can occur at the margin of normal perfused retina and capillary dropout or in Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il`
severe cases of ischemia at the optic disc. This type is prone to grow into the vitreous. Vessels are
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brittle and subject to vitreous traction that can cause bleeding which can lead to significant
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vitreous hemorrhage.
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When Neovascularization is pervasive and there is fibrosis that has infiltrated the vitreous, it is
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called retinitis proliferans.
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Time Domain OCT Il` Il`
Comparison of light waves from the retina was derived from a time delay. Beam going through Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il`
eye has slight delay before it reaches the detector. A scan beam moved from one scan to the next
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through a rapidly rotating mirror. Meant acquisition time was specific and sometimes spanned
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several seconds.
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Original made in 1996, not as quick. Not used as much due to scan acquisition taking too long
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allowing patient to blink which caused artifacts in the image. Also specificity of scan (<1mm across
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and 2mm down through tissue) made it easy to miss pathology by mere micrometers.
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Spectral domain OCT (Fourier domain OCT) Il` Il` Il` Il` Il`
Greater tissue resolving power, higher scan density, and faster data acquisition than Time
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domain ____.
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Relies on changes in spectra in the layers rather than relying on time of flight changes for
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comparison. Rotating mirror was replaced with a stationary spectrophotometer at the detector.
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This allows scans to be performed more quickly. Ability to perform multiple B-scans in rapid
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succession. Much less likely to "miss" pathology. Also has increased axial resolution.
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Retinal Neovascularization Il`
Retinas response to a lack of oxygen or blood flow in the retina. When the retina becomes
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ischemic (lack of blood flow), the body's response is to grow new vessels in the retina to help
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reestablish blood flow. Problem is these new vessels are leaky and fragile, end up creating more
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damage.
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Cause is slow to develop like in diabetic retinopathy and central retinal vein occlusions.
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,Doesn't develop after artery occlusions due to sudden and complete cutoff of blood supply, with
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limited viable cells reacting to the ischemic environment by releasing VEGF (Vascular endothelial
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growth factor)
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Appearance: ('Tangled Thread') Fine, thread like vessels that are different than normal retinal Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il`
vessels.
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Testing: FA Il`
Macular Edema (ME)/ (#2) Diabetic macular edema Il` Il` Il` Il` Il` Il`
Build-up of fluid in the macula. Fluid buildup causes layers within the macula to swell and thicken,
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which distorts vision.
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Most commonly age related.
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Imaging:
- Thickening of the center of the retina
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- Retinal vessels become leaky and fluid accumulates within the macula (inraretinal)
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-Cysts are formed Il` Il`
For this to be categorized as #2 must have diabetes along with #1
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Other causes: inflammation from infections, post ocular surgery, and diseases that affect vessel
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health in and around macular region like diabetic retinopathy and retinal vascular occlusions.
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Testing: OCT, Posterior pole, FA. Il` Il` Il` Il`
Central Serous Retinopathy (CSR) Il` Il` Il`
A disorder that causes a _____ detachment in the Macula. Occurs spontaneously and often
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resolves without intervention.
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, Small break in the outer blood retina barrier(RPE) allows Fluid to build up under the retina. The
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fluid leakage comes from a layer of tissue under the retina, called the choroid. The layer of cells
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between the retina and choroid is called the retinal pigment epithelium (RPE).
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When RPE does not work as it should, fluid builds up under the retina or the RPE resulting in a
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small detachment and visual distortion (metamorphophopsia), loss of visual acuity, and
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sometimes color change (dyschromatopsia). Most patients return to 20/25 or better vision.
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Looks very similar to Macular Degeneration. Subretinal fluid build up related to: increase in
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steroid levels, from medications or endogenous sources such as stress, chronic disease, and
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pregnancy.
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Posterior Pole. FA. Il` Il`
During an FA source of break will be identified with a pinpoint hyperfluorescent leak occurring
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early on, which will gradually pool and fill the _____ detachment/blister later. Mid phase will
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show "smokestack" appearance for the leak - classically seen in Central ____ Retinopathy. Early
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frames to catch the origin of leak and late frames to demonstrate extent of blister.
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Sometimes go to 10 min lates on FA to show full extent of leaking and pooling. Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il`
Under Exposure Il`
Too little light hitting image sensor causing the image to appear dark and loss of detail in
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shadows.
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Hyperopia
Farsightedness , Patients can see objects that are further away clearly and objects that are close Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il` Il`
to their face appear blurred.
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Eyeball is too short, causing the light to be refracted behind it.
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Occurs when cornea doesn't provide enough refraction, creating an issue where the plane of
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focus occurs behind the retinal plane.
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