Antitubercular Drugs, Pharm CH 43 Antimalarial,
Antiprotozoal, and Anthelmintic Drugs, Lilley Chapter 42:
Antifungal Drugs Study Guide
1. The nurse is discussing adverse effects of antitubercular drugs with a
patient who has active tuberculosis. Which potential adverse effect of
antitubercular drug therapy should the patient report to the
prescriber?
a. Gastrointestinal upset
b. Headache and nervousness
c. Reddish-orange urine and stool
d. Numbness and tingling of extremities Ans✓✓✓ ANS: D
Patients on antitubercular therapy should report experiencing
numbness and tingling of extremities, which may indicate peripheral
neuropathy. Some drugs may color the urine, stool, and other body
secretions reddish-orange, but this is not an effect that needs to be
reported. Patients need to be informed of this expected effect. The
other options are incorrect.
DIF: COGNITIVE LEVEL: Applying (Application) REF: p. 668
TOP: NURSING PROCESS: Implementation
1. The nurse is providing patient teaching for a patient who is starting
antitubercular drug therapy. Which of these statements should be
included? (Select all that apply.)
,a. "Take the medications until the symptoms disappear."
b. "Take the medications at the same time every day."
c. "You will be considered contagious during most of the illness and
must take precautions to avoid spreading the disease."
d. "Stop taking the medications if you have severe adverse effects."
e. "Avoid alcoholic beverages while on this therapy."
f. "If you notice reddish-brown or reddish-orange urine, stop taking the
drug and contact your doctor right away."
g. "If you experience a burning or tingling in your fingers or toes, report
it to your prescriber immediately."
h. "Oral contraceptives may not work while you are taking these drugs,
so you will have to use another form of birth control." Ans✓✓✓ ANS:
B, E, G, H
Medications for tuberculosis must be taken on a consistent schedule to
maintain blood levels. Medication therapy for tuberculosis may last up
to 24 months, long after symptoms disappear, and patients are
infectious during the early part of the treatment. Compliance with
antitubercular drug therapy is key, so if symptoms become severe, the
prescriber should be contacted for an adjustment of the drug therapy.
The medication must not be stopped. Because of potential liver toxicity,
patients on this drug therapy must not drink alcohol. Discoloration of
the urine is an expected adverse effect, and patients need to be warned
about it beforehand. Burning or tingling in the fingers or toes may
indicate that peripheral neuropathy is developing, and the prescriber
needs to be notified immediately. A second form of birth control must
be used because antitubercular drug therapy makes oral contraceptives
ineffective.
, DIF: COGNITIVE LEVEL: Applying (Application) REF: pp. 667-668
TOP: NURSING PROCESS: Implementation
10. A patient newly diagnosed with tuberculosis (TB) has been taking
antitubercular drugs for 1 week calls the clinic and is very upset. He
says, "My urine is dark orange! What's wrong with me?" Which
response by the nurse is correct?
a. "You will need to stop the medication, and it will go away."
b. "It's possible that the TB is worse. Please come in to the clinic to be
checked."
c. "This is not what we usually see with these drugs. Please come in to
the clinic to be checked."
d. "This is an expected side effect of the medicine. Let's review what to
expect." Ans✓✓✓ ANS: D
Rifampin, one of the first-line drugs for TB, causes a red-orange-brown
discoloration of urine, tears, sweat, and sputum. Patients need to be
warned about this side effect. The other options are incorrect.
DIF: COGNITIVE LEVEL: Applying (Application) REF: p. 668
TOP: NURSING PROCESS: Assessment
2. A patient who has been taking isoniazid (INH) has a new prescription
for pyridoxine. She is wondering why she needs this medication. The