Adalimumab (Humira) Ans✓✓✓ Treats RA, Crohn's disease and
ulcerative colitis
AED & alcohol Ans✓✓✓ Avoid alcohol during AED (anti epilepsy)
therapy to prevent sedation and toxicity
Antihypertensive interaction Ans✓✓✓ Aldesleukin (IL-2) combined
with antihypertensive meds may lead to additive hypotension
Atomexetine (Strattera) Ans✓✓✓ Treat ADHD, monitor for depression
or suicidal thoughts in adolescents
Auto induction Ans✓✓✓ Drug level is lower than expected
Autoimmune, inflammatory, infectious Ans✓✓✓ Monoclonal antibody
capillary leak syndrome Ans✓✓✓ Associated with interleukin therapy,
sudden weight gain (15 lbs) severe fluid retention
Carbamazepine (Tegretol) auto induction Ans✓✓✓ Lower than
expected drug concentration, dosage adjustment within two months
, Common side effect for Cyclosporine Ans✓✓✓ Hypertension
Contraindications for immunosuppressant drugs Ans✓✓✓ Pregnancy,
liver & renal failure
Cyclosporine (Sandimmune) class & MOA Ans✓✓✓
Immunosuppressant
Inhibit Il-2 production and T cell activation, prevents organ rejection
cyclosporine administration Ans✓✓✓ Sandimmune is not
interchangeable with cyclosporine modified products
Cyclosporine interactions Ans✓✓✓ grapefruit juice, increase levels by
20-200% causing toxicity
Dangerous side effect of Doxapram (Dopram) Ans✓✓✓ Respiratory
depression
Dilantin (phenytoin) dose Ans✓✓✓ 10-20 mcg/mL
Drug interaction for Aldesleukin (proleukin) Ans✓✓✓
Antihypertensives
Epoetin Alfa (epogen) Ans✓✓✓ hematopoietic drugs