BIO 351: Module 1 Exam Notes
A mouse with a floxed FGF8 allele was bread to a
mouse with a Cre recombinase transgene that is
expressed only in the forelimb, not the hindlimb.
Which of the following will be true? Correct
Answers The cells of the forelimbs will have
recombined FGF8 genes
Application of FGF8 coated beads induce limb
mesenchymal cell proliferation. In contrast, FGF8
cpated beads implanted on the epidermis on the
back do not promote proliferation. This experiment
is of? Correct Answers Competence
As cells move along the continuum from stem cell
to differentiated cell which of the following
correctly identifies the properties of a determined
cell? Correct Answers Fate is irreversible
Autonomous Specification Correct Answers Cells
achieve their fates by factors received from their
parental cells, i, irrespective of surrounding cells
(mostly invertebrates)
Conditional Specification Correct Answers Cells
achieve their fates by interactions with other cells;
cell to cell communications (mostly vertebrates)
, During eye development, a region of the
developing brain grows outwards to be adjacent to
the surface ectoderm. These two tissues then
differentiate into the retina and lens, respectively.
Placing a piece of aluminum foil between these two
tissues blocks both of these differentiation
processes. However, placing a piece of permeable
membrane allows both processes to proceed.
Based on these observations, what type of
signaling is taking place? Correct Answers
Paracrine-inducer released from a distance
Embryonic stem cells represented a scientific
breakthrough and allowed for the development of
technologies such as knockout mice. Which of the
following best describes some key attributes of ES
cells? Correct Answers They are pluripotent and
can be manipulated in culture.
If you have a mouse line that expresses Cre
recombinase under the control of a heart specific
enhancer. Which of the following is true? Correct
Answers ONLY cells in the heart express Cre
recombinase
If you have targeted ES cells and inject them into a
blastocyst which of the following will be true?
Correct Answers Some embryonic cells will have
the targeted gene
A mouse with a floxed FGF8 allele was bread to a
mouse with a Cre recombinase transgene that is
expressed only in the forelimb, not the hindlimb.
Which of the following will be true? Correct
Answers The cells of the forelimbs will have
recombined FGF8 genes
Application of FGF8 coated beads induce limb
mesenchymal cell proliferation. In contrast, FGF8
cpated beads implanted on the epidermis on the
back do not promote proliferation. This experiment
is of? Correct Answers Competence
As cells move along the continuum from stem cell
to differentiated cell which of the following
correctly identifies the properties of a determined
cell? Correct Answers Fate is irreversible
Autonomous Specification Correct Answers Cells
achieve their fates by factors received from their
parental cells, i, irrespective of surrounding cells
(mostly invertebrates)
Conditional Specification Correct Answers Cells
achieve their fates by interactions with other cells;
cell to cell communications (mostly vertebrates)
, During eye development, a region of the
developing brain grows outwards to be adjacent to
the surface ectoderm. These two tissues then
differentiate into the retina and lens, respectively.
Placing a piece of aluminum foil between these two
tissues blocks both of these differentiation
processes. However, placing a piece of permeable
membrane allows both processes to proceed.
Based on these observations, what type of
signaling is taking place? Correct Answers
Paracrine-inducer released from a distance
Embryonic stem cells represented a scientific
breakthrough and allowed for the development of
technologies such as knockout mice. Which of the
following best describes some key attributes of ES
cells? Correct Answers They are pluripotent and
can be manipulated in culture.
If you have a mouse line that expresses Cre
recombinase under the control of a heart specific
enhancer. Which of the following is true? Correct
Answers ONLY cells in the heart express Cre
recombinase
If you have targeted ES cells and inject them into a
blastocyst which of the following will be true?
Correct Answers Some embryonic cells will have
the targeted gene
