Lehne's Pharmacology Exam 1 Ch 1-6
2. Absorption determines intensity & time of the effects
3. 3 ways to cross a cell - channels and pores(electrolytes/ions)
membrane - transport systems (P-glycoprotein)
- direct penetration of the membrane(lipid soluble)
4. blood-brain barrier Blood vessels (capillaries) that selectively let certain
substances enter the brain tissue and keep other substances out
5. Routes of Drug Ad- Parenteral-(via injection) ministration: Intravenous,
intramuscular, subcutaneous (SC)
Enteral/Oral- by mouth
, Lehne's Pharmacology Exam 1 Ch 1-6
9. What are therapeutic Accelerated renal secretion consequences of me- Drug
inactivation tabolism? increased therapeutic action
Activation of pro drugs
increased or decreased
toxicity
, Lehne's Pharmacology Exam 1 Ch 1-6
10. Prodrugs are inactive and must be metaboliz/activated in the liver
11. Considerations for Age-induction& inhibition of drug metabolizing enz drug
metabolism
12. Faster metabolization need a higher dosage of a drug =____
13. Induction of metabol- stimulating enzyme synthesis ic enzymes
14. drug excretion the process of eliminating medications, usually through the
kidneys in urine, but also through sweat, feces, and saliva, milk production
15. kidney excretion -blood is filtered through the glomerulus of the kidneys
-molecules that are sufficiently polar from metabolism
will be excreted out of the nephron
-those that are still not polar enough will be re-
absorbed back into the blood
16. Active tubular secre- active transport systems in the renal tubule work to move
some drugs from
tion the blood and into the urine (Acids and bases)
2. Absorption determines intensity & time of the effects
3. 3 ways to cross a cell - channels and pores(electrolytes/ions)
membrane - transport systems (P-glycoprotein)
- direct penetration of the membrane(lipid soluble)
4. blood-brain barrier Blood vessels (capillaries) that selectively let certain
substances enter the brain tissue and keep other substances out
5. Routes of Drug Ad- Parenteral-(via injection) ministration: Intravenous,
intramuscular, subcutaneous (SC)
Enteral/Oral- by mouth
, Lehne's Pharmacology Exam 1 Ch 1-6
9. What are therapeutic Accelerated renal secretion consequences of me- Drug
inactivation tabolism? increased therapeutic action
Activation of pro drugs
increased or decreased
toxicity
, Lehne's Pharmacology Exam 1 Ch 1-6
10. Prodrugs are inactive and must be metaboliz/activated in the liver
11. Considerations for Age-induction& inhibition of drug metabolizing enz drug
metabolism
12. Faster metabolization need a higher dosage of a drug =____
13. Induction of metabol- stimulating enzyme synthesis ic enzymes
14. drug excretion the process of eliminating medications, usually through the
kidneys in urine, but also through sweat, feces, and saliva, milk production
15. kidney excretion -blood is filtered through the glomerulus of the kidneys
-molecules that are sufficiently polar from metabolism
will be excreted out of the nephron
-those that are still not polar enough will be re-
absorbed back into the blood
16. Active tubular secre- active transport systems in the renal tubule work to move
some drugs from
tion the blood and into the urine (Acids and bases)
