ALPHA-ADRENERGIC ANTAGONISTS
EXAM QUESTIONS AND ANSWERS
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Phenoxybenzamine drug class - ANS Nonselective alpha blockers
Phenoxybenzamine brand name - ANS Dibenzyline
Phenoxybenzamine MOA - ANS Binds covalently to alpha 1 and alpha 2 receptors to block
Phenoxybenzamine indications - ANS Pre-operative management to treat vascular effects of
high circulating catecholamines when operating on a pheochromocytoma
- Tumor tends to dump NE/Epi when physically disturbed
Phenoxybenzamine other info - ANS Onset is slow because of time required to form covalent
bonds and offset is very slow (t1/2 ~ 24 hours) because new receptors must be made
Phentolamine drug class - ANS Nonselective alpha blockers
Phentolamine brand name - ANS OraVerse