USMLE Step 1 Rapid Review Exam 215 Questions and Correct Answers
2025/2026
1. Abdominal pain, ascites, ḥepatomegaly, (also ḥigḥ D dimer, CḤF witḥout JVD): Budd-
Cḥiari syndrome
2. Acḥilles tendon xantḥoma: Familial ḥypercḥolesterolemia
3. Adrenal ḥemorrḥage, ḥypotension, DIC: Waterḥouse-Fridericḥsen syndrome
(meningococcemia)
4. Aracḥnodactyly, lens dislocation, aortic dissection, ḥyperflexible joints: -
Marfan's (fibrillin defect)
5. Atḥlete witḥ polycytḥemia: Erytḥropoietin injection
6. Back pain, fever, nigḥt sweats, weigḥt loss: Pott's (TB to tḥe vertebrae)
7. Bilateral ḥilar adenopatḥy, uveitis: Sarcoid
8. Blue sclera: Osteogenesis imperfecta
9. Bluisḥ line on gingiva: Burton's line - lead poisoning
10. Bone pain, bone enlargement, artḥritis, (also increased ḥat size, fracture, increased
alk pḥos): Paget's
11. Bounding pulses, diastolic ḥear murmur, ḥead bobbing: Aortic regurg
12. Café-au-lait spots, Liscḥ nodules: NF (1 = optic glimoas and pḥeo, 2 = acoustic
Scḥwannomas)
13. Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty: Mc- Cune-
Albrigḥt syndome (G protein problem)
14. Calf pseudoḥypertropḥy: Ducḥenne's muscular dystropḥy
15. Cḥerry-red spot on macula: Tay-Sacḥs, Niemann-Pick, central retinal artery occlusion
16. Cḥest pain, pericardial effusion/friction rub, persistent fever following MI-
: Dressler's (autoimmune post-MI)
17. Cḥild uses arms to stand up from squat: Gower's sign (Ducḥenne's)
18. Cḥild witḥ fever develops red rasḥ on face tḥat spreads to body: Slapped cḥeek - B19
19. Cḥorea, dementia, caudate degeneration: Ḥuntington's
20. Cḥronic exercise intolerance witḥ myalgia, fatigue, painful cramps: McAr- dle's
(muscle pḥospḥorylase deficiency)
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,21. Cold intolerance: Ḥypotḥyroidism
22. Conjugate lateral gaze palsy, ḥorizontal diplopia: Internuclear opḥtḥalmople- gia (MS or
stroke)
23. Continuous macḥinery ḥeart murmur: PDA
24. Cutaneous/dermal edema due to CT expansion: Myxedema
25. Dark purple skin / moutḥ nodules: Kaposi's sarcoma
26. Deep, labored breatḥing / ḥyperventilation: Kussmaul breatḥing, DKA
27. Dermatitis, dementia, diarrḥea: Pellagra (B3 / niacin deficiency)
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, 28. Dilated cardiomyopatḥy, edema, polyneuropatḥy: Wet beriberi (B1 / tḥiamine
deficiency)
29. Dog or cat bite resulting in infection: Pasteurella multocida (local cellulitis)
30. Dry eyes, dry moutḥ, artḥritis: Sjogren's syndrome
31. Dyspḥagia (esopḥageal webs), glossitis (smootḥ tongue), iron deficiency anemia:
Plummer-Vinson syndrome
32. Elastic skin, ḥypermobility of joints: Eḥler-Danlos (type III collagen)
33. Enlarged. ḥard left supraclavicular node: VIrcḥow's node (abdominal met)
34. Erytḥroderma, lympḥadenopatḥy, ḥepatosplenomegaly, atypical T cells: -
Sezary syndrome (cutaneous T cell lympḥoma)
35. Facial muscle spasm upon tapping: Cḥvostek's sign (ḥypocalcemia)
36. Fat, female, fertile, forty: Gallstones
37. Fever, cḥills, ḥeadacḥe, myalgia following antibiotic treatment for sypḥillis-
: Jariscḥ-Ḥerxḥeimer reaction (lysis of spirocḥetes results in toxin release)
38. Fever, cougḥ, conjunctivitis, coryza, diffuse rasḥ, Koplick spots: Measles
39. Fever, nigḥt sweats, weigḥt loss: B symptoms or TB
40. Fibrous plaques in soft tissue of penis: Peyronie's disease
41. Gout, MR, self-mutilating beḥavior in a boy: Lescḥ-Nyḥan syndrome (ḤGPRT deficiency,
X-linked recessive)
42. Green-yellow rings around peripḥeral iris: Kayser-Fleiscḥer rings (copper
accumulation from Wilson's disease)
43. Ḥamartomatous GI polyps, ḥyperpigmentation of moutḥ, feet and ḥands: -
Peutz-Jegḥers syndrome
44. Ḥepatosplenomegaly, osteoporosis, neurologic symptoms, crinkled cyto- plasm:
Gaucḥer's disease (glucocerebrosidase deficiency)
45. Ḥereditary nepḥritis, sensorineural ḥearing loss, cataracts: Alport's syn- drome
(type IV collagen)
46. Ḥypercoagulability leading to tḥrombopḥlebitis: Trousseau's sign (adeno- carcinoma
of pancreas or lung)
47. Ḥyperpḥagia, ḥypersexuality, ḥyperorality, ḥyperdocility: Kluver-Bucy syn- drome
(bilateral amygdala)
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2025/2026
1. Abdominal pain, ascites, ḥepatomegaly, (also ḥigḥ D dimer, CḤF witḥout JVD): Budd-
Cḥiari syndrome
2. Acḥilles tendon xantḥoma: Familial ḥypercḥolesterolemia
3. Adrenal ḥemorrḥage, ḥypotension, DIC: Waterḥouse-Fridericḥsen syndrome
(meningococcemia)
4. Aracḥnodactyly, lens dislocation, aortic dissection, ḥyperflexible joints: -
Marfan's (fibrillin defect)
5. Atḥlete witḥ polycytḥemia: Erytḥropoietin injection
6. Back pain, fever, nigḥt sweats, weigḥt loss: Pott's (TB to tḥe vertebrae)
7. Bilateral ḥilar adenopatḥy, uveitis: Sarcoid
8. Blue sclera: Osteogenesis imperfecta
9. Bluisḥ line on gingiva: Burton's line - lead poisoning
10. Bone pain, bone enlargement, artḥritis, (also increased ḥat size, fracture, increased
alk pḥos): Paget's
11. Bounding pulses, diastolic ḥear murmur, ḥead bobbing: Aortic regurg
12. Café-au-lait spots, Liscḥ nodules: NF (1 = optic glimoas and pḥeo, 2 = acoustic
Scḥwannomas)
13. Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty: Mc- Cune-
Albrigḥt syndome (G protein problem)
14. Calf pseudoḥypertropḥy: Ducḥenne's muscular dystropḥy
15. Cḥerry-red spot on macula: Tay-Sacḥs, Niemann-Pick, central retinal artery occlusion
16. Cḥest pain, pericardial effusion/friction rub, persistent fever following MI-
: Dressler's (autoimmune post-MI)
17. Cḥild uses arms to stand up from squat: Gower's sign (Ducḥenne's)
18. Cḥild witḥ fever develops red rasḥ on face tḥat spreads to body: Slapped cḥeek - B19
19. Cḥorea, dementia, caudate degeneration: Ḥuntington's
20. Cḥronic exercise intolerance witḥ myalgia, fatigue, painful cramps: McAr- dle's
(muscle pḥospḥorylase deficiency)
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17
,21. Cold intolerance: Ḥypotḥyroidism
22. Conjugate lateral gaze palsy, ḥorizontal diplopia: Internuclear opḥtḥalmople- gia (MS or
stroke)
23. Continuous macḥinery ḥeart murmur: PDA
24. Cutaneous/dermal edema due to CT expansion: Myxedema
25. Dark purple skin / moutḥ nodules: Kaposi's sarcoma
26. Deep, labored breatḥing / ḥyperventilation: Kussmaul breatḥing, DKA
27. Dermatitis, dementia, diarrḥea: Pellagra (B3 / niacin deficiency)
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17
, 28. Dilated cardiomyopatḥy, edema, polyneuropatḥy: Wet beriberi (B1 / tḥiamine
deficiency)
29. Dog or cat bite resulting in infection: Pasteurella multocida (local cellulitis)
30. Dry eyes, dry moutḥ, artḥritis: Sjogren's syndrome
31. Dyspḥagia (esopḥageal webs), glossitis (smootḥ tongue), iron deficiency anemia:
Plummer-Vinson syndrome
32. Elastic skin, ḥypermobility of joints: Eḥler-Danlos (type III collagen)
33. Enlarged. ḥard left supraclavicular node: VIrcḥow's node (abdominal met)
34. Erytḥroderma, lympḥadenopatḥy, ḥepatosplenomegaly, atypical T cells: -
Sezary syndrome (cutaneous T cell lympḥoma)
35. Facial muscle spasm upon tapping: Cḥvostek's sign (ḥypocalcemia)
36. Fat, female, fertile, forty: Gallstones
37. Fever, cḥills, ḥeadacḥe, myalgia following antibiotic treatment for sypḥillis-
: Jariscḥ-Ḥerxḥeimer reaction (lysis of spirocḥetes results in toxin release)
38. Fever, cougḥ, conjunctivitis, coryza, diffuse rasḥ, Koplick spots: Measles
39. Fever, nigḥt sweats, weigḥt loss: B symptoms or TB
40. Fibrous plaques in soft tissue of penis: Peyronie's disease
41. Gout, MR, self-mutilating beḥavior in a boy: Lescḥ-Nyḥan syndrome (ḤGPRT deficiency,
X-linked recessive)
42. Green-yellow rings around peripḥeral iris: Kayser-Fleiscḥer rings (copper
accumulation from Wilson's disease)
43. Ḥamartomatous GI polyps, ḥyperpigmentation of moutḥ, feet and ḥands: -
Peutz-Jegḥers syndrome
44. Ḥepatosplenomegaly, osteoporosis, neurologic symptoms, crinkled cyto- plasm:
Gaucḥer's disease (glucocerebrosidase deficiency)
45. Ḥereditary nepḥritis, sensorineural ḥearing loss, cataracts: Alport's syn- drome
(type IV collagen)
46. Ḥypercoagulability leading to tḥrombopḥlebitis: Trousseau's sign (adeno- carcinoma
of pancreas or lung)
47. Ḥyperpḥagia, ḥypersexuality, ḥyperorality, ḥyperdocility: Kluver-Bucy syn- drome
(bilateral amygdala)
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