Veterinary Pharmacology Final Exam
Questions And Answers
Phospholipase b- bcorrect banswers✔✔Phospholipids bare bmade binto barachidonic bacid
bby bwhat benzymes?
Cyclooxygenase b- bcorrect banswers✔✔Arachidonic bacid bis bmade binto bPGG2 bby
bwhat benzyme?
Anti-inflammatory, banalgesic band bantipyretic b- bcorrect banswers✔✔What bare bthe b3
bpharmacological beffects bof bNSAIDs?
Anti-inflammatory b- bcorrect banswers✔✔What bpharmacological beffects bof bNSAIDs?
- bmodifications bof binflammatory breactions
- bdecrease bin binflammatory bprostaglandin bproduction
Analgesic b- bcorrect banswers✔✔What bpharmacological beffects bof bNSAIDs?
- breduction bof bpain
Antipyretic b- bcorrect banswers✔✔What bpharmacological beffects bof bNSAIDs?
- blowering bof braised btemperature
- bpartly bdue bto bdecreased brelease bof bprostaglandins bin bresponse bto binterleukin-1
b(IL-1)
TXA2 b- bcorrect banswers✔✔The bantithrombotic beffect bis ba bside beffect bof bNSAIDs
bbecause bthey binhibit b____ bsynthesis
False b(causes bstomach bulcers band binternal bbleeding) b- bcorrect
banswers✔✔True/False
Concurrent buse bof bcorticosteroids band bNSAIDs bshould bbe bavoided bdue bto
bincreased brisk bof brenal bfailure?
COX2 b- bcorrect banswers✔✔Which bCOX bis bthe binducible bform? bAlso bit bsynthesizes
bprostaglandins bresponsible bfor binflammation band bpain
COX1 b- bcorrect banswers✔✔Which bCOX bis bthe bbasal bform? bAlso bit bsynthesizes
bprostaglandins bfor bmaintenance band bprotection bof bthe bGI btract
,Aspirin b- bcorrect banswers✔✔____ banti-inflammatory bMechanism, bpermanently
binactivates bprostaglandin bsynthase buntil bit bis breplaced bby bnew bsynthesis,
bgranulocytes b(neutrophils, beosinophils, bmast bcells, band bbasophils) balso beffected
Rimadyl b(Carprofen) b- bcorrect banswers✔✔- bWorld's bmost bfrequently bprescribed
bcanine bNSAID
- bIndicated bfor bthe brelief bof bpain band binflammation bassociated bwith bosteoarthritis bin
bdogs
- bReceived bapproval bfor bcontrolling bpost boperative bpain bassociated bwith bsoft btissue
band borthopedic bsurgery bin bdogs
- bLower bincidence bof bGI bdisturbance
False b(NEVER) b- bcorrect banswers✔✔True/False
You bcan bsometimes badminister bcats bCarprofen b(Rimadyl) bfor bOA
injectable b- bcorrect banswers✔✔The b____ bform bof bRimadyl bis bindicated bfor bthe
bcontrol bof bpain band binflammation bassociated bwith bosteoarthritis band bboth bsoft
btissue band borthopedic bsurgeries
phenobarbital b- bcorrect banswers✔✔Concurrent buse bof bcarprofen band b____ bcan
balter bthe bactivity bof bone bor bboth bdrugs
Zubrin b(Tepoxalin) b- bcorrect banswers✔✔___ bmechanism bof baction bis binhibition bof
bcyclooxygenase bactivity band blipoxygenase band bis bthus bclassified bas ba bdual
binhibitor bof barachidonic bacid bmetabolism
True b- bcorrect banswers✔✔True/False
Zubrin bis bnot bapproved bin bcats
leukotrienes b- bcorrect banswers✔✔By busing bZubrin bin bdogs byou bare binhibiting
blipoxygenase bwhich bis bused bto bproduced binflammatory b_____
Previcox b(firocoxib) b- bcorrect banswers✔✔- bApproved bto btreat bpain band
binflammation bin bdogs bsuffering bfrom bosteoarthritis band breported bto bhave b24-hour
btherapeutic bpain brelief
- bselectively binhibit bCOX-2 bcyclooxygenase bactivity
False b- bcorrect banswers✔✔True/False
Previcox bis bindicated bfor buse bin bcats
Anorexia b- bcorrect banswers✔✔What bis bthe bcommon binitial bsign bin banimals bwho
bhave ba brisk bof bhepatotoxicity bwhen bon ban bNSAID
ALT b- bcorrect banswers✔✔3-4 bfold bincreases bin b___ b(a blab btest) babove bnormal
brange bmay bbe ban bindication bof bacute bhepatopathy bwhen ba bdog bis bon ban bNSAID
, Cosequin b(glucosamine band bchondroitin bsulfate) b- bcorrect banswers✔✔is bmarketed
bas ba bveterinary bnutraceutical, band bclaims bto bstimulate bthe bsynthesis bof bsynovial
bfluid band binhibits bdegradation bof bthe barticular bcartilage
Adequan b- bcorrect banswers✔✔- bis ban bFDA-approved bglycosaminoglycan
bpolysulfate bester band bis bcommonly bcalled bP-GAGS
- bone bclinical bstudy bof bdogs bwith bhip bdysplasia bfound bgreatest bimprovement bin
borthopedic bscores bat bdosages bof b4.4 bmg/kg, bIM bevery b3-5 bdays bfor b8 binjections
broad b- bcorrect banswers✔✔____ bspectrum bantibacterials bare bactive bagainst bboth
bGram-positive band bGram-negative borganisms. b
- bExamples binclude: btetracyclines, bphenicols, bfluoroquinolones, b"third-generation"
band b"fourth-generation" bcephalosporins.
narrow b- bcorrect banswers✔✔____ bspectrum bantibacterials bhave blimited bactivity band
bare bprimarily bonly buseful bagainst bparticular bspecies bof bmicroorganisms. b
- bFor bexample, bglycopeptides band bbacitracin bare bonly beffective bagainst bGram-
positive bbacteria, bwhereas bpolymixins bare busually bonly beffective bagainst bGram
bnegative bbacteria. bAminoglycosides band bsulfonamides bare bonly beffective bagainst
baerobic borganisms, bwhile bnitroimidazoles bare bgenerally bonly beffective bfor
banaerobes.
Positive b- bcorrect banswers✔✔Gram b___ bbacteria
- bStreptococcus bspp.
- bStaphylococcus bspp.
- bClostridium bperfringens
- bCorynebacterium
Negative b- bcorrect banswers✔✔Gram b___ bbacteria
Escherichia bcoli
Proteus bspp.
Pseudomonas bspp.
Salmonella bspp.
Brucella
Vibrio
Pasterurella bspp.
Penicillins band bcephalosporins b- bcorrect banswers✔✔Inhibition bof bCell bWall
bSynthesis b(bactericidal)
Polymixin bB b- bcorrect banswers✔✔Alter bcell bmembrane bpermeability b(bactericidal)
Questions And Answers
Phospholipase b- bcorrect banswers✔✔Phospholipids bare bmade binto barachidonic bacid
bby bwhat benzymes?
Cyclooxygenase b- bcorrect banswers✔✔Arachidonic bacid bis bmade binto bPGG2 bby
bwhat benzyme?
Anti-inflammatory, banalgesic band bantipyretic b- bcorrect banswers✔✔What bare bthe b3
bpharmacological beffects bof bNSAIDs?
Anti-inflammatory b- bcorrect banswers✔✔What bpharmacological beffects bof bNSAIDs?
- bmodifications bof binflammatory breactions
- bdecrease bin binflammatory bprostaglandin bproduction
Analgesic b- bcorrect banswers✔✔What bpharmacological beffects bof bNSAIDs?
- breduction bof bpain
Antipyretic b- bcorrect banswers✔✔What bpharmacological beffects bof bNSAIDs?
- blowering bof braised btemperature
- bpartly bdue bto bdecreased brelease bof bprostaglandins bin bresponse bto binterleukin-1
b(IL-1)
TXA2 b- bcorrect banswers✔✔The bantithrombotic beffect bis ba bside beffect bof bNSAIDs
bbecause bthey binhibit b____ bsynthesis
False b(causes bstomach bulcers band binternal bbleeding) b- bcorrect
banswers✔✔True/False
Concurrent buse bof bcorticosteroids band bNSAIDs bshould bbe bavoided bdue bto
bincreased brisk bof brenal bfailure?
COX2 b- bcorrect banswers✔✔Which bCOX bis bthe binducible bform? bAlso bit bsynthesizes
bprostaglandins bresponsible bfor binflammation band bpain
COX1 b- bcorrect banswers✔✔Which bCOX bis bthe bbasal bform? bAlso bit bsynthesizes
bprostaglandins bfor bmaintenance band bprotection bof bthe bGI btract
,Aspirin b- bcorrect banswers✔✔____ banti-inflammatory bMechanism, bpermanently
binactivates bprostaglandin bsynthase buntil bit bis breplaced bby bnew bsynthesis,
bgranulocytes b(neutrophils, beosinophils, bmast bcells, band bbasophils) balso beffected
Rimadyl b(Carprofen) b- bcorrect banswers✔✔- bWorld's bmost bfrequently bprescribed
bcanine bNSAID
- bIndicated bfor bthe brelief bof bpain band binflammation bassociated bwith bosteoarthritis bin
bdogs
- bReceived bapproval bfor bcontrolling bpost boperative bpain bassociated bwith bsoft btissue
band borthopedic bsurgery bin bdogs
- bLower bincidence bof bGI bdisturbance
False b(NEVER) b- bcorrect banswers✔✔True/False
You bcan bsometimes badminister bcats bCarprofen b(Rimadyl) bfor bOA
injectable b- bcorrect banswers✔✔The b____ bform bof bRimadyl bis bindicated bfor bthe
bcontrol bof bpain band binflammation bassociated bwith bosteoarthritis band bboth bsoft
btissue band borthopedic bsurgeries
phenobarbital b- bcorrect banswers✔✔Concurrent buse bof bcarprofen band b____ bcan
balter bthe bactivity bof bone bor bboth bdrugs
Zubrin b(Tepoxalin) b- bcorrect banswers✔✔___ bmechanism bof baction bis binhibition bof
bcyclooxygenase bactivity band blipoxygenase band bis bthus bclassified bas ba bdual
binhibitor bof barachidonic bacid bmetabolism
True b- bcorrect banswers✔✔True/False
Zubrin bis bnot bapproved bin bcats
leukotrienes b- bcorrect banswers✔✔By busing bZubrin bin bdogs byou bare binhibiting
blipoxygenase bwhich bis bused bto bproduced binflammatory b_____
Previcox b(firocoxib) b- bcorrect banswers✔✔- bApproved bto btreat bpain band
binflammation bin bdogs bsuffering bfrom bosteoarthritis band breported bto bhave b24-hour
btherapeutic bpain brelief
- bselectively binhibit bCOX-2 bcyclooxygenase bactivity
False b- bcorrect banswers✔✔True/False
Previcox bis bindicated bfor buse bin bcats
Anorexia b- bcorrect banswers✔✔What bis bthe bcommon binitial bsign bin banimals bwho
bhave ba brisk bof bhepatotoxicity bwhen bon ban bNSAID
ALT b- bcorrect banswers✔✔3-4 bfold bincreases bin b___ b(a blab btest) babove bnormal
brange bmay bbe ban bindication bof bacute bhepatopathy bwhen ba bdog bis bon ban bNSAID
, Cosequin b(glucosamine band bchondroitin bsulfate) b- bcorrect banswers✔✔is bmarketed
bas ba bveterinary bnutraceutical, band bclaims bto bstimulate bthe bsynthesis bof bsynovial
bfluid band binhibits bdegradation bof bthe barticular bcartilage
Adequan b- bcorrect banswers✔✔- bis ban bFDA-approved bglycosaminoglycan
bpolysulfate bester band bis bcommonly bcalled bP-GAGS
- bone bclinical bstudy bof bdogs bwith bhip bdysplasia bfound bgreatest bimprovement bin
borthopedic bscores bat bdosages bof b4.4 bmg/kg, bIM bevery b3-5 bdays bfor b8 binjections
broad b- bcorrect banswers✔✔____ bspectrum bantibacterials bare bactive bagainst bboth
bGram-positive band bGram-negative borganisms. b
- bExamples binclude: btetracyclines, bphenicols, bfluoroquinolones, b"third-generation"
band b"fourth-generation" bcephalosporins.
narrow b- bcorrect banswers✔✔____ bspectrum bantibacterials bhave blimited bactivity band
bare bprimarily bonly buseful bagainst bparticular bspecies bof bmicroorganisms. b
- bFor bexample, bglycopeptides band bbacitracin bare bonly beffective bagainst bGram-
positive bbacteria, bwhereas bpolymixins bare busually bonly beffective bagainst bGram
bnegative bbacteria. bAminoglycosides band bsulfonamides bare bonly beffective bagainst
baerobic borganisms, bwhile bnitroimidazoles bare bgenerally bonly beffective bfor
banaerobes.
Positive b- bcorrect banswers✔✔Gram b___ bbacteria
- bStreptococcus bspp.
- bStaphylococcus bspp.
- bClostridium bperfringens
- bCorynebacterium
Negative b- bcorrect banswers✔✔Gram b___ bbacteria
Escherichia bcoli
Proteus bspp.
Pseudomonas bspp.
Salmonella bspp.
Brucella
Vibrio
Pasterurella bspp.
Penicillins band bcephalosporins b- bcorrect banswers✔✔Inhibition bof bCell bWall
bSynthesis b(bactericidal)
Polymixin bB b- bcorrect banswers✔✔Alter bcell bmembrane bpermeability b(bactericidal)
