NUR 2063 Pathophysiology Final Rasmussen College

o A state in which all systems are in balance. State of equilibrium. Maintaining internal conditions stable. - Homeostasis o Ability to successfully adapt to challenges. Intricate regulatory processes orchestrated by the brain. - Allostasis: Study of diseases within a population. Epidemiology is the method used to find the causes of health outcomes and diseases in populations. - Epidemiology: o primary: Altering susceptibility or reducing exposure for susceptible person (Example: Immunization) o secondary: Early detection screening, and management of disease. (Example: cancer screening, performing months breast examinations) o tertiary: Rehabilitation, supportive care, reducing disability, and restoring effective functioning. (Example: PT/OT following stroke) - Review the different levels of disease prevention such as primary, secondary, and tertiary as well as examples for each. o Sympathetic: Fight or Flight response o Parasympathetic: Rest and digest - Review the differences between the sympathetic vs the parasympathetic nervous systems. o Body focuses on specific organs and tissue to survive until body alleviates itself from stressor § Dilate pupils § Inhibit salivation § Increase heartbeat § Relax airway § Inhibit activity of stomach § Stimulate relapse of glucose; inhibit gallbladder § vii.Inhibit activity of intestine § viii.Secrete epi and norepinephrine § Relax bladder § Promote ejaculation and vaginal contraction - What happens to the body during "fightor- flight" response? Antigenic response beyond what is considered normal Response to antigens (allergens) leading to damage: Type I :Anaphylaxtic Type II: Cytotoxic Type III: Immune complex hypersensitivity Type Iv: Delayed cell mediated - What is a hypersensitivity? Review the four different types of hypersensitivities: o Active immunity: When the body creates antibodies when coming into contact with a virus. Ex: Vaccination o Passive immunity: Passing on antigens. Ex: Breast feeding - Review the difference between active and passive immunity, know examples for each type. vActive - when the body creates a antibodies once coming into contact with specific virus Passive - when passed from mother to child through breast milk or blood stream - Review the difference between active and passive immunity, know examples for each type. o Increases in capillary hydrostatic pressure (blood vessel blockage, incompetent venous valves o Increased capillary permeability (inflammation) o Congestive heart failure o High blood volume or HTN o Decrease in plasma proteins (such as albumin) o Blockage of lymphatic drainage (due to cancer or removal of lymph tissue) - Review the various factors that can contribute to edema. -Benign More closely resembles original tissue type Grows more slowly Little vascularity Rarely necrotic Does not invade adjacent tissue or spread to distant sites Malignant -Malignant cells ignore growth controlling signals -Proliferate despite lack of growth-initiating signals from the environment -Escape signals to die and achieve a kind of immortality -Display a lack of differentiated features(anaplasia) and contribute poorly or not at all to the function of their tissue Metastasis - process by which cancer cells escape their tissue of origin and initiate new colonies of cancer in distant sites - Review the differences between benign and malignant tumors. Benign: Localized, generally curable -More closely resembles original tissue type -Grows more slowly -Little vascularity -Rarely necrotic -Often retains original function -Noninvasive, does not invade adjacent tissue Malignant: Ex: Anastasia, and metastasis -Malignant cells ignore growth controlling signals -Proliferate despite lack of growth-initiating signals from the environment -Escape signals to die and achieve a kind of immortality -Display a lack of differentiated features(anaplasia) and contribute poorly or not at all to the function of their tissue - Review the differences between benign and malignant tumors. Caused by Stress, smoking, genetics. No relation between diet and PUD. Caused by NSAIDS, stress (gluccocorticoids) smoking Bacterial infection: H. Pylori key role in promoting both gastric and duodenal ulcer formation, thrives in acidic conditions, slow rate of ulcer healing, high rate of recurrence, clearance of Hy. Pyloric promotes ulcer healing Clinical Manifestations: Epigastric burning pain- occurs on an empty stomach. Pain of duodenal ulcer classically occurs to 2-3 hours after. Meal. Treatment: Reduce acidity to heal the injured mucosa, antibiotics, proton pumps inhibitors, sucralfate. - Review signs and symptoms of peptic ulcer disease. Inflammation of vermiform appendix. Obstruction by fecalith. Rebound tenderness.Systemic signs of inflammation Check blood work, "mcburnies point" - Review signs and symptoms of appendicitis. How do we assess for this condition? Signs and symptoms of Liver disease o Jaundice of the eyes - Staining issues by bilirubin - Results from impaired bilirubin metabolism o Bloody stool - Review signs and symptoms of liver disease. Review complications of liver disease such as ascites, hepatic encephalopathy and esophageal varices. How are esophageal varices managed/treated? Helps keep fluid in blood vessels and helps transport materials like vitamins, enzymes, and hormones. Liver failure decreases albumin production - What role does albumin play in the blood? What happens to albumin production with liver failure? Function of kidneys o Regulate water and electrolyte levels o Produces erythropoietin Assessment: o CVA tenderness o Urine test 1. Dipstick and microscopic urinalysis o Ultra sound - What are the function of the kidneys? How do we assess for renal disorders? a. Cystic kidney disease - Genetically transmitted renal disorder, resulting in fluid filled; may be localized to one area or affect both kidneys b. Causes - autosomal recessive forms, autosomal dominant types (most common, symptoms appears later in life) - What is cystic kidney disease? What causes this condition? a. Nephrons - helps create urine b. Hematuria - blood in urine c. Proteinuria - protein in urine d. Nephrolithiasis - kidney stones e. Pyelonephritis - type of urinary tract infection, starts out as a UTI then travels to kidneys f. Cystitis - bladder infection - Review the following terms: · nephrons, · hematuria, · proteinuria, · nephrolithiasis, · pyelonephritis, · cystitis Signs & symptoms a. Disruptions in fluid, electrolyte, and acid-base balances b. Retention of nitrogenous waste products c. Increased serum creatinine d. Decreased glomerular filtration rate (GFR) Prerenal: Disruptions to renal perfusion. Ex: Hypovolemia, hypotension Postrenal: Disruption to urine flow distal to. the kidneys.Ex: Stone in ureter, tumor, enlarged prostate Intrinsic: Damage/ disruptions within the kidney blood vessels, tubules or glomeruli Ex: Damage to renal tubules resulting in acute tubular necrosis - Review signs and symptoms of acute kidney injury (AKI). Review causes of AKI including prerenal, intrinsic, and postrenal. Know examples of each type of injury. o Dangerous complication of soft-tissue injury - results from swelling of injured tissue within a restrictive fascia o Causes - decreased compartment size, increased compartment content, or externally applied pressure