Nanomedicine Test 5 2025
Questions and Answers 100% Pass
Preclinical - in vitro and vivo studies, animal models, safety; Phase I - 10 participants,
humans, understand effects; Phase 2 - 20-50, humans, safety and efficacy; Phase 3 - 100-
200, humans, confirm benefits and safety, FDA approval after this; Phase 4 - 200+,
humans, evaluate long term effects - ✔✔what are the phases of a clinical trial?
in vivo and vitro, animal models, research and safety - ✔✔What set of experiments
involves the preclinical phase?
traditional - weakened or inactivated pathogens, purified or recombinantly produced
viral proteins with adjuvants; mRNA - no oncogenic potential, faster to make, no
pathogen growth, flexible stockpiling approach, stable for decades - ✔✔Describe the
difference between traditional vaccines and mRNA based vaccines.
No pathogen growth needed, no adjuvant needed - ✔✔Explain why mRNA vaccines
can be developed faster than traditional ones.
mediates receptor recognition and membrane fusion - how the virus gets into the cell
and is the primary target for the immune response - ✔✔Why is the coronavirus Spike
glycoprotein has been selected as a vaccine target?
heat, RNAses - ✔✔What could trigger premature degradation of mRNA?
COPYRIGHT © 2025 BY GRACE AMELIA, ALL RIGHTS RESERVED 1
Questions and Answers 100% Pass
Preclinical - in vitro and vivo studies, animal models, safety; Phase I - 10 participants,
humans, understand effects; Phase 2 - 20-50, humans, safety and efficacy; Phase 3 - 100-
200, humans, confirm benefits and safety, FDA approval after this; Phase 4 - 200+,
humans, evaluate long term effects - ✔✔what are the phases of a clinical trial?
in vivo and vitro, animal models, research and safety - ✔✔What set of experiments
involves the preclinical phase?
traditional - weakened or inactivated pathogens, purified or recombinantly produced
viral proteins with adjuvants; mRNA - no oncogenic potential, faster to make, no
pathogen growth, flexible stockpiling approach, stable for decades - ✔✔Describe the
difference between traditional vaccines and mRNA based vaccines.
No pathogen growth needed, no adjuvant needed - ✔✔Explain why mRNA vaccines
can be developed faster than traditional ones.
mediates receptor recognition and membrane fusion - how the virus gets into the cell
and is the primary target for the immune response - ✔✔Why is the coronavirus Spike
glycoprotein has been selected as a vaccine target?
heat, RNAses - ✔✔What could trigger premature degradation of mRNA?
COPYRIGHT © 2025 BY GRACE AMELIA, ALL RIGHTS RESERVED 1
