NANOMEDICINE TEST 3 2025
QUESTIONS AND ANSWERS
100% PASS
difference between nano devices and nanoparticles - ✔✔- nano devices: they are made
of nanoparticles (usually with different composition -- ex. microneedles and nano
needles, and nano-valves for drug delivery)
- nanoparticles: particle of any shape with dimensions in the 1 x 10 ^-9 - 1x10 ^-7 (1-
100nm)
why did we study micro-needles if they are not a nano object? - ✔✔because they are
still relevant in the field of medicine. Microneedles permit transport of macromolecules,
as well as possibly supramolecular complexes and Microparticles
which skin layer can be reached using micro-needles? - ✔✔stratum corneum
describe the three transdermal drug delivery methods using micro-needles - ✔✔1. poke
with a patch -- use for insulin delivery into diabetic hairless rats (sol of insulin was
placed on top of the micro needle array and left)
2. coat and poke -- used for protein vaccine delivery (microneedles prepared with dry
film coating of antigen and then inserted into skin of hairless guinea pig -- possible
allergy treatment?)
COPYRIGHT © 2025 BY GRACE AMELIA, ALL RIGHTS RESERVED 1
, 3. dip and scrape -- used for DNA delivery (arrays dipped into a solution of DNA and
scraped multiple times across the skin of mice to create micro abrasions)
which skin layer can be reached using nano-needles? - ✔✔can only reach the upper
layer of the epidermis because they are too small to penetrate the stratum corneum
what are the main applications of nano-needles - ✔✔drug delivery without
nanoparticles and manipulation of organelles
describe and understand how it works the nano-valve designed by Zink et al - ✔✔- a
nano-valve that can be opened and closed (trap and release molecules0 -- could be used
for drug delivery such as insulin release
how it works:
1. guest molecule is loaded into the pores (by diffusion)
2. valve is closed bc of oxidation of TTF
3. valve is opened by adding ascorbic acid to reduce TTF (position of CBPQT4 ring
changes)
4. release of the guest molecule
what is nano-endoscopy as defined by Zhang et al - ✔✔- single cell endoscopy: probes
accurately inserted into a live cell (allows for intracellular analysis)
- Zhang et al fabricated a nano device -- assembled single nanoporus gold nanowire on
the tip of a tungsten needle (+ NP to sense different cell types)
COPYRIGHT © 2025 BY GRACE AMELIA, ALL RIGHTS RESERVED 2
QUESTIONS AND ANSWERS
100% PASS
difference between nano devices and nanoparticles - ✔✔- nano devices: they are made
of nanoparticles (usually with different composition -- ex. microneedles and nano
needles, and nano-valves for drug delivery)
- nanoparticles: particle of any shape with dimensions in the 1 x 10 ^-9 - 1x10 ^-7 (1-
100nm)
why did we study micro-needles if they are not a nano object? - ✔✔because they are
still relevant in the field of medicine. Microneedles permit transport of macromolecules,
as well as possibly supramolecular complexes and Microparticles
which skin layer can be reached using micro-needles? - ✔✔stratum corneum
describe the three transdermal drug delivery methods using micro-needles - ✔✔1. poke
with a patch -- use for insulin delivery into diabetic hairless rats (sol of insulin was
placed on top of the micro needle array and left)
2. coat and poke -- used for protein vaccine delivery (microneedles prepared with dry
film coating of antigen and then inserted into skin of hairless guinea pig -- possible
allergy treatment?)
COPYRIGHT © 2025 BY GRACE AMELIA, ALL RIGHTS RESERVED 1
, 3. dip and scrape -- used for DNA delivery (arrays dipped into a solution of DNA and
scraped multiple times across the skin of mice to create micro abrasions)
which skin layer can be reached using nano-needles? - ✔✔can only reach the upper
layer of the epidermis because they are too small to penetrate the stratum corneum
what are the main applications of nano-needles - ✔✔drug delivery without
nanoparticles and manipulation of organelles
describe and understand how it works the nano-valve designed by Zink et al - ✔✔- a
nano-valve that can be opened and closed (trap and release molecules0 -- could be used
for drug delivery such as insulin release
how it works:
1. guest molecule is loaded into the pores (by diffusion)
2. valve is closed bc of oxidation of TTF
3. valve is opened by adding ascorbic acid to reduce TTF (position of CBPQT4 ring
changes)
4. release of the guest molecule
what is nano-endoscopy as defined by Zhang et al - ✔✔- single cell endoscopy: probes
accurately inserted into a live cell (allows for intracellular analysis)
- Zhang et al fabricated a nano device -- assembled single nanoporus gold nanowire on
the tip of a tungsten needle (+ NP to sense different cell types)
COPYRIGHT © 2025 BY GRACE AMELIA, ALL RIGHTS RESERVED 2
