NURS 5315 MSK EXAM QUESTIONS WITH CORRECT WELL
VERIFIED ANSWERS GRADED A+ FOR GUARANTEED PASS
A patient with scurvy presents with fragile bones. What nutritional deficiency is
responsible, and why does it affect bone health?
a. Vitamin D deficiency; it reduces calcium absorption, leading to weak bones
.b. Vitamin K deficiency; it impairs osteocalcin activation, leading to reduced bone
mineralization.
c. Vitamin C deficiency; it impairs collagen synthesis, weakening the bone matrix.
d. Calcium deficiency; it directly reduces bone density and strength. - ✅✅c.
Vitamin C deficiency; it impairs collagen synthesis, weakening the bone matrix.
What therapeutic target would be appropriate for a drug designed to reduce
osteoclast activity in osteoporosis?
a. Stimulating sclerostin production to enhance osteoblast inhibition.
b. Inhibiting RANKL activity or increasing OPG levels to prevent osteoclast
differentiation
.c. Activating RANK signaling to enhance osteoclast activity.
d. Blocking osteocalcin production to reduce bone remodeling. - ✅✅b.
Inhibiting RANKL activity or increasing OPG levels to prevent osteoclast
differentiation.
,Which antigen is most strongly associated with ankylosing spondylitis?
a. HLA-DR4
b. HLA-B27
c. HLA-A2
d. HLA-B7 - ✅✅b. HLA-B27
What is a characteristic feature of ankylosing spondylitis on X-ray imaging?
a. Osteophyte formation
b. Erosive changes in metacarpophalangeal joints
c. Bamboo spine
d. Subcutaneous nodules - ✅✅c. Bamboo spine
The pathophysiology of ankylosing spondylitis primarily involves which structure?
a. Synovial membrane
b. Fibrocartilage at entheses
c. Articular cartilage
d. Subchondral bone - ✅✅b. Fibrocartilage at entheses
Which postural change is associated with advanced ankylosing spondylitis?
, a. Increased lumbar lordosis
b. Increased thoracic kyphosis
c. Ulnar deviation of fingers
d. Swan-neck deformity - ✅✅b. Increased thoracic kyphosis
Which early symptom is most characteristic of ankylosing spondylitis?
a. Morning stiffness improving with activity
b. Symmetric joint swelling
c. Pain relieved by rest
d. Acute onset joint pain - ✅✅a. Morning stiffness improving with activity
What is the primary pathophysiological hallmark of osteoarthritis?
a. Synovial inflammation
b. Loss of articular cartilage
c. Autoantibody production
d. Enthesitis - ✅✅b. Loss of articular cartilage
Which factor increases the risk of osteoarthritis?
a. Low body mass index
b. HLA-B27 positivity
VERIFIED ANSWERS GRADED A+ FOR GUARANTEED PASS
A patient with scurvy presents with fragile bones. What nutritional deficiency is
responsible, and why does it affect bone health?
a. Vitamin D deficiency; it reduces calcium absorption, leading to weak bones
.b. Vitamin K deficiency; it impairs osteocalcin activation, leading to reduced bone
mineralization.
c. Vitamin C deficiency; it impairs collagen synthesis, weakening the bone matrix.
d. Calcium deficiency; it directly reduces bone density and strength. - ✅✅c.
Vitamin C deficiency; it impairs collagen synthesis, weakening the bone matrix.
What therapeutic target would be appropriate for a drug designed to reduce
osteoclast activity in osteoporosis?
a. Stimulating sclerostin production to enhance osteoblast inhibition.
b. Inhibiting RANKL activity or increasing OPG levels to prevent osteoclast
differentiation
.c. Activating RANK signaling to enhance osteoclast activity.
d. Blocking osteocalcin production to reduce bone remodeling. - ✅✅b.
Inhibiting RANKL activity or increasing OPG levels to prevent osteoclast
differentiation.
,Which antigen is most strongly associated with ankylosing spondylitis?
a. HLA-DR4
b. HLA-B27
c. HLA-A2
d. HLA-B7 - ✅✅b. HLA-B27
What is a characteristic feature of ankylosing spondylitis on X-ray imaging?
a. Osteophyte formation
b. Erosive changes in metacarpophalangeal joints
c. Bamboo spine
d. Subcutaneous nodules - ✅✅c. Bamboo spine
The pathophysiology of ankylosing spondylitis primarily involves which structure?
a. Synovial membrane
b. Fibrocartilage at entheses
c. Articular cartilage
d. Subchondral bone - ✅✅b. Fibrocartilage at entheses
Which postural change is associated with advanced ankylosing spondylitis?
, a. Increased lumbar lordosis
b. Increased thoracic kyphosis
c. Ulnar deviation of fingers
d. Swan-neck deformity - ✅✅b. Increased thoracic kyphosis
Which early symptom is most characteristic of ankylosing spondylitis?
a. Morning stiffness improving with activity
b. Symmetric joint swelling
c. Pain relieved by rest
d. Acute onset joint pain - ✅✅a. Morning stiffness improving with activity
What is the primary pathophysiological hallmark of osteoarthritis?
a. Synovial inflammation
b. Loss of articular cartilage
c. Autoantibody production
d. Enthesitis - ✅✅b. Loss of articular cartilage
Which factor increases the risk of osteoarthritis?
a. Low body mass index
b. HLA-B27 positivity
