PATHOPHYSIOLOGY
THEBIOLOGICBASISFORDISEASEINADULTSANDCHILDREN
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8thEdition
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KathrynL.McCance,SueE.Huether
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Contents
Chapter 01: Cellular Biology ...........................................................................................................................4
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Chapter 02: Altered Cellular and Tissue Biology: Environmental Agents .........................................................18
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Chapter 03: The Cellular Environment: Fluids and Electrolytes, Acids and Bases .............................................31
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Chapter 04: Genes and Genetic Diseases .......................................................................................................44
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Chapter 05: Genes, Environment-Lifestyle,and Common Diseases ...............................................................55
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Chapter 06: Epigenetics and Disease ............................................................................................................63
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Chapter 07: Innate Immunity: Inflammation and Wound Healing ..................................................................68
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Chapter 08: Adaptive Immunity ...................................................................................................................83
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Chapter 09: Alterationsin Immunity and Inflammation .................................................................................95
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Chapter 10: Infection .................................................................................................................................108
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Chapter 11: Stress and Disease ...................................................................................................................117
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Chapter 12: Cancer Biology ........................................................................................................................124
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Chapter 13: Cancer Epidemiology...............................................................................................................137
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Chapter 14: Cancerin Children ...................................................................................................................143
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Chapter 15: Structure and Function ofthe Neurologic System.....................................................................148
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Chapter 16: Pain, Temperature Regulation, Sleep, andSensory Function.....................................................159
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Chapter 17: Alterationsin Cognitive Systems,Cerebral Hemodynamics, and Motor Function .....................174
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Chapter 18: Disorders ofthe Centraland Peripheral Nervous Systems andthe Neuromuscular Junction
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. ............................................................................................................................................................ 188
Chapter 19: Neurobiology of Schizophrenia,Mood Disorders, and Anxiety Disorders ...................................199
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Chapter 20: Alterations ofNeurologic Function in Children .........................................................................206
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Chapter 21:MechanismsofHormonalRegulation .......................................................................................213
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Chapter 22:Alterations ofHormonal Regulation .........................................................................................222
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Chapter 23: Obesity andDisorders of Nutrition ...........................................................................................234
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Chapter 24: Structure and Function ofthe Reproductive Systems ...............................................................239
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Chapter 25: Alterations of the Female Reproductive System .......................................................................249
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Chapter 26: Alterations of the Male Reproductive System ..........................................................................259
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Chapter 27: Sexually Transmitted Infections ..............................................................................................265
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Chapter 28: Structure and Function ofthe Hematologic System..................................................................273
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Chapter 29: Alterations ofErythrocytes, Platelets, andHemostatic Function ...............................................283
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Chapter 30: Alterations ofLeukocyte and Lymphoid Function......................................................................293
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Chapter 31: Alterations ofHematologic Function in Children .......................................................................300
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Chapter 32: Structure and Function ofthe Cardiovascular and Lymphatic Systems ......................................311
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Chapter 33: Alterations ofCardiovascular Function ....................................................................................324
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Chapter 34: Alterations ofCardiovascular Function in Children ....................................................................338
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Chapter 35: Structure and Function ofthePulmonary System .....................................................................346
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Chapter 36: Alterations ofPulmonary Function .........................................................................................356
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Chapter 37: Alterations ofPulmonary Function inChildren ..........................................................................373
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Chapter 38: Structure and Function ofthe Renal and Urologic Systems ........................................................381
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Chapter 39: Alterations ofRenal and Urinary Tract Function .......................................................................391
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Chapter 40: Alterations ofRenal and Urinary Tract Function in Children ........................................................401
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Chapter 41:Structure andFunction oftheDigestive System ........................................................................409
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Chapter 42: Alterations ofDigestive Function .............................................................................................421
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Chapter 43: Alterations ofDigestive Function in Children ............................................................................432
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Chapter 44: Structure and Function ofthe Musculoskeletal System............................................................441
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Chapter 45: Alterations ofMusculoskeletal Function ..................................................................................453
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Chapter 46: Alterations ofMusculoskeletal Function in Children .................................................................466
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Chapter 47: Structure, Function, andDisorders of the Integument ...............................................................475
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Chapter 48: Alterations ofthe Integument in Children .................................................................................486
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Chapter 49: Shock,Multiple OrganDysfunction Syndrome, and Burnsin Adults ............................................494
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Chapter 50: Shock,Multiple OrganDysfunction Syndrome, and Burnsin Children.........................................502
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, TestBank -Pathophysiology:TheBiologicBasisforDiseaseinAdultsand Children(8th)
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Chapter01:CellularBiology e
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MULTIPLE CHOICE xe
1. Whichstatement best describes the cellularfunction of metabolic absorption?
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a. Cells can produceproteins. xe xe xe
b. Cellscansecrete digestiveenzymes. xe xe xe xe
c. Cellscantakeinandusenutrients. xe xe xe xe xe
d. Cellscan synthesizefats. xe xe xe
ANS: C x e
In metabolic absorption,all cells takein and use nutrients and other substances from their
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surroundings. The remainingoptions arenot inclusive in their descriptions of cellular
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metabolicabsorption.
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PTS: x e x e 1 DIF: CognitiveLevel: Remembering xe xe
2. Whereismostofacell’s geneticinformation,includingRNAand DNA,contained?
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a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: C x e
Thenucleus contains the nucleolus, a small dense structurecomposed largelyofRNA, most oft he cellular
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DNA, and the DNA-binding proteins, such as the histones, which regulate its activity.
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The mitochondria are responsible for cellular respiration and energyproduction.
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x Ribosomes’chieffunction isto provide sitesforcellularprotein synthesis. Lysosomesfunctionas
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the intracellular digestive system.
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PTS: x e x e 1 DIF: CognitiveLevel: Remembering xe xe
3. Whichcomponentofthecellproduceshydrogenperoxide(H2O2)byusingoxygento
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removehydrogen atoms from specific substrates in an oxidative reaction?
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a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: B x e