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Exam (elaborations)

PCOL 131 final exam SAR and resistance questions with correct answers 2025

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PCOL 131 final exam SAR and resistance questions with correct answers 2025

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  • pcol 131 final exam sar and resistance questions w

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PCOL 131 final exam SAR and resistance
questions with correct answers 2025
PenamsH(Penicillins)HSARH-HCORRECTHANSWERH-R1

1.HControlsHoralHabsorption

2.HGovernsHspectrumH

3.HConfersHbetaHlactamaseHresistanceHviaHbulk



COOH:HcriticalHtoHmimicHcarboxylateHofHD-ala



CephemsHSARH-HCORRECTHANSWERH-R1

1.HControlsHoralHabsorption

2.HGovernsHspectrum

3.HConfersHbetaHlactamaseHresistanceHviaHadjacentHdoubleHbond



R2

1.HAffectsHbetaHlactamHreactivityHandHabsorptionHfromHintestines/absorptionHintoHgramH(-)H



COOH:HcriticalHtoHmimicHcarboxylateHofHD-ala



PenamsH(Penicillins)HActivityH-HCORRECTHANSWERH-
EWGHonHR1HsubstituentHwillHincreaseHacidHstability



CombattingHResistanceHAgainstHPenicillinaseH-HCORRECTHANSWERH-
IncreaseHstericHbulkHnextHtoHC6Hcarbonyl

, CarbapenemsHSARH-HCORRECTHANSWERH-TransHgeometry



CephemsH(Cephalosporins)HActivityH-HCORRECTHANSWERH-
1.HEWGHonHR1HwillHincreaseHacidHstability

2.HEWGH(moreHpolar)HonHR2HwillHincreaseHreactivity,HbutHalsoHincreasedHhydrophobicityHcorrelates
HwithHincreasedHabsorptionHandHdistributionH



-
TheHmoreHEWGHatHC3,HtheHgreaterHtheHantibacterialHactivityHofHtheHdrugHbutHalsoHtheHworstHtheHa
bsorptionH(solutionH=HquaternaryHnitrogens)



CombattingHResistanceHAgainstHCephalosporinasesH-HCORRECTHANSWERH-7-methoxy



PropertiesHofHAllHBetaHLactamsH-HCORRECTHANSWERH-IncreasingHreactivity

1.HAddHanHextraHringH

2.HAddHdoubleHbindsH



OralHActivity

1.HWithstandHacidHinHstomachH(needsHtoHbeHmoreHEW)

2.HBeHabsorbedHinHSIH(needsHtoHbeHmoreHhydrophobic)



CarbapenemsHActivityH-HCORRECTHANSWERH-
SusceptibleHtoHhumanHproteaseHb/cHit'sHdownHlikeHtheHLHconfigurationHofHAA

-CilastinHoftenHco-administeredHw/Himipenem



VancomycinHSARH-HCORRECTHANSWERH-
1.HLipophilicHsideHchainHanchorsHmembrane,HgivesHprolongedHhalfHlife,HandHincreasesHactivityHagai
nstHenterococci

2.HSugarHallowsHdimerization
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