APHON Principles of Biotherapy UPDATED
ACTUAL Exam Questions and CORRECT
Answers
biotherapy - CORRECT ANSWER - modality of tx: agents that resemble body's own defense
and surveillance systems. can augment/modulate/restore host's immune response, direct
antitumor activity, other biological effects. side effects typically hypersensitivity rx
immune surveillance - CORRECT ANSWER - tumor cells express abnormal tumor antigens
on surface that can be recognized/destroyed by immune system
natural killer cells - CORRECT ANSWER - lymphocyte that recognizes/kills malignant cells
cytotoxic t cells - CORRECT ANSWER - recognize tumor-assosiated antigens and kills cells
interferons - CORRECT ANSWER - multiple moa's & produced w/ recombinant dna.
protein capable of protecting other cells from viral infections by interfering w/ viral replication.
family of glycoproteins include: antiviral, antiproliferative, potent immunomodulatory effects
cytokines - CORRECT ANSWER - products of immune cells to enhance cytotoxic activity of
cells and increase immune response
alpha-interferon - CORRECT ANSWER - leukocyte-derived. tx: hairy cell leukemia,
melanoma, chronic myeloid leukemia, follicular lymphoma, multiple myeloma, cutaneous t-cell
lymphoma
beta-interferon - CORRECT ANSWER - fibroblast-derived. tx MS
, gamma-interferon - CORRECT ANSWER - t-lymphocyte derived. tx chronic granulomatus
disease
interleukin-2 - CORRECT ANSWER - produced by t-helper cells & stimulate
growth/maturation of t-cell subsets, cytotoxic t-cells, production of lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
retinoids - CORRECT ANSWER - immunomodulators that facilitate differentiation &
suppress proliferation of cancer cells
all-trans retinoic acid (atra) - CORRECT ANSWER - tx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of coagulopathy r/t tx.
isotretinoin (accutane) - CORRECT ANSWER - retinoid tx neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC. male/female pt must register iPledge
(fetal exposure). can also affect hearing & vision
antibodies - CORRECT ANSWER - proteins produced by b-lymphocytes. part of humoral
immunity of adaptive system. includes immunoglobulins (igG, igA, igM, igE, igD)
murine - CORRECT ANSWER - mouse-derived MoAbs. pt develops human antimouse
antibodies creating high risk of hypersensitivity rx
end in -momab
Monoclonal antibodies - CORRECT ANSWER - very specific. directed against single
antigenic determinant on cell surface causing antibody-dependent cellular toxicity, direct cell
death, elimination of antigen/target cell that expresses the antigen
low toxicity
-ximab - CORRECT ANSWER - moab combo of human & mouse antibodies
ACTUAL Exam Questions and CORRECT
Answers
biotherapy - CORRECT ANSWER - modality of tx: agents that resemble body's own defense
and surveillance systems. can augment/modulate/restore host's immune response, direct
antitumor activity, other biological effects. side effects typically hypersensitivity rx
immune surveillance - CORRECT ANSWER - tumor cells express abnormal tumor antigens
on surface that can be recognized/destroyed by immune system
natural killer cells - CORRECT ANSWER - lymphocyte that recognizes/kills malignant cells
cytotoxic t cells - CORRECT ANSWER - recognize tumor-assosiated antigens and kills cells
interferons - CORRECT ANSWER - multiple moa's & produced w/ recombinant dna.
protein capable of protecting other cells from viral infections by interfering w/ viral replication.
family of glycoproteins include: antiviral, antiproliferative, potent immunomodulatory effects
cytokines - CORRECT ANSWER - products of immune cells to enhance cytotoxic activity of
cells and increase immune response
alpha-interferon - CORRECT ANSWER - leukocyte-derived. tx: hairy cell leukemia,
melanoma, chronic myeloid leukemia, follicular lymphoma, multiple myeloma, cutaneous t-cell
lymphoma
beta-interferon - CORRECT ANSWER - fibroblast-derived. tx MS
, gamma-interferon - CORRECT ANSWER - t-lymphocyte derived. tx chronic granulomatus
disease
interleukin-2 - CORRECT ANSWER - produced by t-helper cells & stimulate
growth/maturation of t-cell subsets, cytotoxic t-cells, production of lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
retinoids - CORRECT ANSWER - immunomodulators that facilitate differentiation &
suppress proliferation of cancer cells
all-trans retinoic acid (atra) - CORRECT ANSWER - tx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of coagulopathy r/t tx.
isotretinoin (accutane) - CORRECT ANSWER - retinoid tx neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC. male/female pt must register iPledge
(fetal exposure). can also affect hearing & vision
antibodies - CORRECT ANSWER - proteins produced by b-lymphocytes. part of humoral
immunity of adaptive system. includes immunoglobulins (igG, igA, igM, igE, igD)
murine - CORRECT ANSWER - mouse-derived MoAbs. pt develops human antimouse
antibodies creating high risk of hypersensitivity rx
end in -momab
Monoclonal antibodies - CORRECT ANSWER - very specific. directed against single
antigenic determinant on cell surface causing antibody-dependent cellular toxicity, direct cell
death, elimination of antigen/target cell that expresses the antigen
low toxicity
-ximab - CORRECT ANSWER - moab combo of human & mouse antibodies
