NUSCTX 103 EXAM 1 – PROTEIN EXAM
QUESTIONS AND ANSWERS
Microbial proteases may metabolize branched chain AA to... - Answer-isobutyrate
and isovalerate which may be absorbed and/or excreted in stool
Microbial proteases may hydrolyze peptides & proteins and▪ may metabolize AA
to.... - Answer-urea which can be used for microbial growth
Congenital disorders of amino acids (aminoacidurias) - Answer-• defects in amino
acid transport/excretion & metabolism that result in disease
• typically a defect in an enzyme
Growing infants, children, pregnant people are in ____ nitrogen balance - Answer-
positive
(intake is greater than excretion)
- supports tissue expansion/growth
what kind of nitrogen balance should adults have - Answer--remain in nitrogen
'balance' (intake matches excretion)
- supports tissue maintenance and turnover
hartnup disease - Answer-▪ Defect in neutral amino acid transporter (SLC6A19/B 0
system)
- reduces absorption of non-polar amino acids
▪ Reduction in Trp absorption reduces the generation of niacin, which in necessary
forthe production of NAD+
- high dietary intakes can compensate
▪ Rash, cerebellar ataxia, delusions
- high overlap with pellagra, vitamin B3 deficiency
celiac disease - Answer-• Genetic autoimmune disease
• Intolerance to gluten, a complex of gliadin and glutenin in wheat, barley, rye
- no enzymes to cleave
• Degeneration of mucosa in upper small intestine (flattening of brush border),
leading to digestion problems
- immune response
QUESTIONS AND ANSWERS
Microbial proteases may metabolize branched chain AA to... - Answer-isobutyrate
and isovalerate which may be absorbed and/or excreted in stool
Microbial proteases may hydrolyze peptides & proteins and▪ may metabolize AA
to.... - Answer-urea which can be used for microbial growth
Congenital disorders of amino acids (aminoacidurias) - Answer-• defects in amino
acid transport/excretion & metabolism that result in disease
• typically a defect in an enzyme
Growing infants, children, pregnant people are in ____ nitrogen balance - Answer-
positive
(intake is greater than excretion)
- supports tissue expansion/growth
what kind of nitrogen balance should adults have - Answer--remain in nitrogen
'balance' (intake matches excretion)
- supports tissue maintenance and turnover
hartnup disease - Answer-▪ Defect in neutral amino acid transporter (SLC6A19/B 0
system)
- reduces absorption of non-polar amino acids
▪ Reduction in Trp absorption reduces the generation of niacin, which in necessary
forthe production of NAD+
- high dietary intakes can compensate
▪ Rash, cerebellar ataxia, delusions
- high overlap with pellagra, vitamin B3 deficiency
celiac disease - Answer-• Genetic autoimmune disease
• Intolerance to gluten, a complex of gliadin and glutenin in wheat, barley, rye
- no enzymes to cleave
• Degeneration of mucosa in upper small intestine (flattening of brush border),
leading to digestion problems
- immune response
