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1) Which of the following DNA mutations can result in the mRNA transcript having a significant
portion of its codons changed? Correct Answ_frameshift mutation
frameshift mutation Correct Answ_mutation that shifts the "reading" frame of the genetic
message by inserting or deleting a nucleotide
missense mutation Correct Answ_A base-pair substitution that results in a codon that codes
for a different amino acid.
neutral mutation Correct Answ_a mutation that has no effect on survival or reproduction
One type of spontaneous mutation involves the removal of an amino group from cytosine which
changes the nucleotide to a uracil. After a couple rounds of replication, the original C-G pair will
now be an T-A pair. This is called: Correct Answ_Deamination
,deamination Correct Answ_the removal of an amino group from an organism, particularly
from an amino acid
depurination Correct Answ_the loss of a purine base from a nucleotide
hydrolysis Correct Answ_Breaking down complex molecules by the chemical addition of
water
alkylation Correct Answ_The transfer of an alkyl group from one molecule to another
Which of the following processes would be expected to repress transcription? Correct
Answ_DNA methylation and Deacetylation
This kind of mutation causes the appearance of a new trait or function Correct Answ_Gain-
of- function
loss of function mutation Correct Answ_causes a complete or partial loss of function
, forward mutation Correct Answ_Changes the wild-type phenotype to a mutant phenotype
Gain-of-function Correct Answ_protein encoded by the mutant gene is changed so it gains a
new or abnormal function
Reverse mutation Correct Answ_changes a mutant phenotype back to the wild-type
phenotype
1) Which of the following are considered "mutagens"? Correct Answ_intercalating agents, x-
rays, alkylating agents, x-rays, base analogues
mutagens Correct Answ_A chemical or physical agent that interacts with DNA and causes a
mutation.
intercalating agents Correct Answ_distort DNA to induce single nucleotide pair insertions
and deletions
Alkylating agents Correct Answ_Absence of digits, multiple anomalies