ONS/ONCC Chemotherapy Immunotherapy Certificate
Study online at https://quizlet.com/_89cxsm
1. Lesson 1: Founda-
tions to Set the
Stage
2. Focusing on Cellu-
lar Structure and
Function
3. The Normal Cell -The cell cycle refers to the ordered seres of processes of DNA replication and
Cycle mitosis, or cell division
-Cell nucleus regulates these processes by gathering and processing complexes
molecular information
4. Interphase and Mi- Cell division produces two identical cells through these two major phases
totic Phase
5. During interphase: Cell grows and DNA is replicated through the following three steps:
1: First growth phase (G1 or first gap)
2: Synthesis phase (S phase)
3:Mitotic Phse (M phase)
6. First Growth Phase -cells increase in size
(G1 or first gap)
-reproduce RNA
-"quality assurance" test that the cell will be ready to synthesis DNA
-Length of time is variable, can be from hours to days
7.
, ONS/ONCC Chemotherapy Immunotherapy Certificate
Study online at https://quizlet.com/_89cxsm
Synthesis Phase (S -DNA replicates
phase)
-Results in the formation of identical pairs of DNA (chromatids)
-which are attached a t the centromere
-lasts 2-10 hours
8. Mitotic Phase (M -Replicated chromosomes are aligned, separated, and move into 2 new, iden-
phase) tical daughter cells
-takes about 30-60 minutes
9. Major points of cell -G1 checkpoint
regulation are en-
try and exit from -S Phase
-G2 checkpoint
-M phase
10. Restriction Point -The transition from the resting phase into an actively dividing phase (G0-G1)
is a point where cellular transformation can occur
-During this time, cells pass through a transition phase known as a restriction
point
-Extracellular growth factors trigger reentry into G1, and GF are required to
send the cells past the restriction point, or the point of no return
11. G0 Phase (resting -After mitosis, cells may enter back into the G1 phase or go into a resting phase,
phase) known as G0
-Most cells in the human body reside in G0
, ONS/ONCC Chemotherapy Immunotherapy Certificate
Study online at https://quizlet.com/_89cxsm
12. -Exceptions to this -Exceptions to this are those that are metabollically active, such as
are those that
are (Resting in G0 -granulocytes
phase)
-and the epithelium of the GI tract
13. Cell Cycling Time Amount of time from mitosis to mitosis
14. Cell cycle video http://highered.mheducation.com/sites/0072495855/student_view0/chap-
and image ter2/animation__how_the_cell_cycle_works.html
15. Check points in the -The cell cycle is carefully controlled through a series of checkpoints
Cell Cycle: Keeping
it All Under Control -Variation in duplication or distribution of chromosomes during cell division can
alter the genetic information passed on to daughter cells, leading to cellular
dysfunction and disease, such as cancer
-These checkpoints monitor for DNA integrity and control progression through
mitosis
16. Progression 1. cyclines (D, E, A, B)
through the cell
cycle is controlled 2. Cyclin-dependent kinases (CDKs)
through two
-Cyclin-CDK complex allows the cell to progress through each phase of the cell
proteins:
cycle
17. Locations of pro- -(G0-G1) : Cyclin D and CDK 4/6
teins Cyclins (D, E,
A, B) and CDKs -Early S: Cyclin E and CDK 1/2
-Late S: Cyclin A and CDK 1/2
-G2: CDK 1/2 and cyclin A
Study online at https://quizlet.com/_89cxsm
1. Lesson 1: Founda-
tions to Set the
Stage
2. Focusing on Cellu-
lar Structure and
Function
3. The Normal Cell -The cell cycle refers to the ordered seres of processes of DNA replication and
Cycle mitosis, or cell division
-Cell nucleus regulates these processes by gathering and processing complexes
molecular information
4. Interphase and Mi- Cell division produces two identical cells through these two major phases
totic Phase
5. During interphase: Cell grows and DNA is replicated through the following three steps:
1: First growth phase (G1 or first gap)
2: Synthesis phase (S phase)
3:Mitotic Phse (M phase)
6. First Growth Phase -cells increase in size
(G1 or first gap)
-reproduce RNA
-"quality assurance" test that the cell will be ready to synthesis DNA
-Length of time is variable, can be from hours to days
7.
, ONS/ONCC Chemotherapy Immunotherapy Certificate
Study online at https://quizlet.com/_89cxsm
Synthesis Phase (S -DNA replicates
phase)
-Results in the formation of identical pairs of DNA (chromatids)
-which are attached a t the centromere
-lasts 2-10 hours
8. Mitotic Phase (M -Replicated chromosomes are aligned, separated, and move into 2 new, iden-
phase) tical daughter cells
-takes about 30-60 minutes
9. Major points of cell -G1 checkpoint
regulation are en-
try and exit from -S Phase
-G2 checkpoint
-M phase
10. Restriction Point -The transition from the resting phase into an actively dividing phase (G0-G1)
is a point where cellular transformation can occur
-During this time, cells pass through a transition phase known as a restriction
point
-Extracellular growth factors trigger reentry into G1, and GF are required to
send the cells past the restriction point, or the point of no return
11. G0 Phase (resting -After mitosis, cells may enter back into the G1 phase or go into a resting phase,
phase) known as G0
-Most cells in the human body reside in G0
, ONS/ONCC Chemotherapy Immunotherapy Certificate
Study online at https://quizlet.com/_89cxsm
12. -Exceptions to this -Exceptions to this are those that are metabollically active, such as
are those that
are (Resting in G0 -granulocytes
phase)
-and the epithelium of the GI tract
13. Cell Cycling Time Amount of time from mitosis to mitosis
14. Cell cycle video http://highered.mheducation.com/sites/0072495855/student_view0/chap-
and image ter2/animation__how_the_cell_cycle_works.html
15. Check points in the -The cell cycle is carefully controlled through a series of checkpoints
Cell Cycle: Keeping
it All Under Control -Variation in duplication or distribution of chromosomes during cell division can
alter the genetic information passed on to daughter cells, leading to cellular
dysfunction and disease, such as cancer
-These checkpoints monitor for DNA integrity and control progression through
mitosis
16. Progression 1. cyclines (D, E, A, B)
through the cell
cycle is controlled 2. Cyclin-dependent kinases (CDKs)
through two
-Cyclin-CDK complex allows the cell to progress through each phase of the cell
proteins:
cycle
17. Locations of pro- -(G0-G1) : Cyclin D and CDK 4/6
teins Cyclins (D, E,
A, B) and CDKs -Early S: Cyclin E and CDK 1/2
-Late S: Cyclin A and CDK 1/2
-G2: CDK 1/2 and cyclin A
